Intramammary infusion of Panax ginseng extract in bovine mammary gland at cessation of milking induces changes in the expression of toll-like receptors, MyD88 and NF-kB during early involution
The purposes of this study were to explore TLR2 and TLR4 participation and MyD88 and NF-κB activation in bovine mammary glands (BMG) treated with Panax ginseng (PG) at involution and verify the effect of PG in the cytokine expression. Quarters were infused at the end of lactation with PG solution (3 mg/ml), placebo or kept as uninoculated controls. Cows were slaughtered at 7 d after cessation of milking and mammary tissue samples were taken. A significant increase of TLR2, TLR4, MyD88, NF-κB, IL-1β, IL-6 and TGF-β1 mRNA expression was observed in PG-treated quarters. Immunostaining of TLR2 and TLR4 was significantly higher in PG mammary tissues. The percentages of immunopositive cells for NF-κB-p65 were significantly higher in PG-treated quarters. The BMG responded to PG extract components possibly by TLR2 and TLR4 signaling pathway. These results provide an insight into potential mechanisms by which PG stimulates innate immunity during BMG involution.
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Format: | info:ar-repo/semantics/artículo biblioteca |
Language: | eng |
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2015-06
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Subjects: | Panax pseudoginseng, Extractos, Ganado Bovino, Glándulas Mamarias, Ordeño, Genética, Extracts, Cattle, Mammary Glands, Milking, Genetics, Panax ginseng, |
Online Access: | https://www.sciencedirect.com/science/article/pii/S0034528815000995 http://hdl.handle.net/20.500.12123/3025 https://doi.org/10.1016/j.rvsc.2015.03.025 |
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Panax pseudoginseng Extractos Ganado Bovino Glándulas Mamarias Ordeño Genética Extracts Cattle Mammary Glands Milking Genetics Panax ginseng Panax pseudoginseng Extractos Ganado Bovino Glándulas Mamarias Ordeño Genética Extracts Cattle Mammary Glands Milking Genetics Panax ginseng |
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Panax pseudoginseng Extractos Ganado Bovino Glándulas Mamarias Ordeño Genética Extracts Cattle Mammary Glands Milking Genetics Panax ginseng Panax pseudoginseng Extractos Ganado Bovino Glándulas Mamarias Ordeño Genética Extracts Cattle Mammary Glands Milking Genetics Panax ginseng Baravalle, Celina Silvestrini, Paula Cadoche, Mónica C. Beccaria, Camila Andreotti, Carolina Soledad Renna, Maria Sol Pereyra, Elizabet Amanda Lorena Ortega, Hugo Hector Calvinho, Luis Fernando Dallard, Bibiana Elisabet Intramammary infusion of Panax ginseng extract in bovine mammary gland at cessation of milking induces changes in the expression of toll-like receptors, MyD88 and NF-kB during early involution |
description |
The purposes of this study were to explore TLR2 and TLR4 participation and MyD88 and NF-κB activation in bovine mammary glands (BMG) treated with Panax ginseng (PG) at involution and verify the effect of PG in the cytokine expression. Quarters were infused at the end of lactation with PG solution (3 mg/ml), placebo or kept as uninoculated controls. Cows were slaughtered at 7 d after cessation of milking and mammary tissue samples were taken. A significant increase of TLR2, TLR4, MyD88, NF-κB, IL-1β, IL-6 and TGF-β1 mRNA expression was observed in PG-treated quarters. Immunostaining of TLR2 and TLR4 was significantly higher in PG mammary tissues. The percentages of immunopositive cells for NF-κB-p65 were significantly higher in PG-treated quarters. The BMG responded to PG extract components possibly by TLR2 and TLR4 signaling pathway. These results provide an insight into potential mechanisms by which PG stimulates innate immunity during BMG involution. |
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info:ar-repo/semantics/artículo |
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Panax pseudoginseng Extractos Ganado Bovino Glándulas Mamarias Ordeño Genética Extracts Cattle Mammary Glands Milking Genetics Panax ginseng |
author |
Baravalle, Celina Silvestrini, Paula Cadoche, Mónica C. Beccaria, Camila Andreotti, Carolina Soledad Renna, Maria Sol Pereyra, Elizabet Amanda Lorena Ortega, Hugo Hector Calvinho, Luis Fernando Dallard, Bibiana Elisabet |
author_facet |
Baravalle, Celina Silvestrini, Paula Cadoche, Mónica C. Beccaria, Camila Andreotti, Carolina Soledad Renna, Maria Sol Pereyra, Elizabet Amanda Lorena Ortega, Hugo Hector Calvinho, Luis Fernando Dallard, Bibiana Elisabet |
author_sort |
Baravalle, Celina |
title |
Intramammary infusion of Panax ginseng extract in bovine mammary gland at cessation of milking induces changes in the expression of toll-like receptors, MyD88 and NF-kB during early involution |
title_short |
Intramammary infusion of Panax ginseng extract in bovine mammary gland at cessation of milking induces changes in the expression of toll-like receptors, MyD88 and NF-kB during early involution |
title_full |
Intramammary infusion of Panax ginseng extract in bovine mammary gland at cessation of milking induces changes in the expression of toll-like receptors, MyD88 and NF-kB during early involution |
title_fullStr |
Intramammary infusion of Panax ginseng extract in bovine mammary gland at cessation of milking induces changes in the expression of toll-like receptors, MyD88 and NF-kB during early involution |
title_full_unstemmed |
Intramammary infusion of Panax ginseng extract in bovine mammary gland at cessation of milking induces changes in the expression of toll-like receptors, MyD88 and NF-kB during early involution |
title_sort |
intramammary infusion of panax ginseng extract in bovine mammary gland at cessation of milking induces changes in the expression of toll-like receptors, myd88 and nf-kb during early involution |
publishDate |
2015-06 |
url |
https://www.sciencedirect.com/science/article/pii/S0034528815000995 http://hdl.handle.net/20.500.12123/3025 https://doi.org/10.1016/j.rvsc.2015.03.025 |
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oai:localhost:20.500.12123-30252018-08-09T12:17:23Z Intramammary infusion of Panax ginseng extract in bovine mammary gland at cessation of milking induces changes in the expression of toll-like receptors, MyD88 and NF-kB during early involution Baravalle, Celina Silvestrini, Paula Cadoche, Mónica C. Beccaria, Camila Andreotti, Carolina Soledad Renna, Maria Sol Pereyra, Elizabet Amanda Lorena Ortega, Hugo Hector Calvinho, Luis Fernando Dallard, Bibiana Elisabet Panax pseudoginseng Extractos Ganado Bovino Glándulas Mamarias Ordeño Genética Extracts Cattle Mammary Glands Milking Genetics Panax ginseng The purposes of this study were to explore TLR2 and TLR4 participation and MyD88 and NF-κB activation in bovine mammary glands (BMG) treated with Panax ginseng (PG) at involution and verify the effect of PG in the cytokine expression. Quarters were infused at the end of lactation with PG solution (3 mg/ml), placebo or kept as uninoculated controls. Cows were slaughtered at 7 d after cessation of milking and mammary tissue samples were taken. A significant increase of TLR2, TLR4, MyD88, NF-κB, IL-1β, IL-6 and TGF-β1 mRNA expression was observed in PG-treated quarters. Immunostaining of TLR2 and TLR4 was significantly higher in PG mammary tissues. The percentages of immunopositive cells for NF-κB-p65 were significantly higher in PG-treated quarters. The BMG responded to PG extract components possibly by TLR2 and TLR4 signaling pathway. These results provide an insight into potential mechanisms by which PG stimulates innate immunity during BMG involution. EEA Rafaela Fil: Baravalle, Celina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular Aplicada; Argentina Fil: Silvestrini, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular Aplicada; Argentina Fil: Cadoche, Mónica C. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular Aplicada; Argentina Fil: Beccaría, Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular Aplicada; Argentina Fil: Andreotti, Carolina Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular Aplicada; Argentina Fil: Renna, Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular Aplicada; Argentina Fil: Pereyra, Elizabet Amanda Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular Aplicada; Argentina Fil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular Aplicada; Argentina Fil: Calvinho, Luis Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina Fil: Dallard, Bibiana Elisabet. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular Aplicada; Argentina 2018-08-09T12:14:26Z 2018-08-09T12:14:26Z 2015-06 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.sciencedirect.com/science/article/pii/S0034528815000995 http://hdl.handle.net/20.500.12123/3025 0034-5288 https://doi.org/10.1016/j.rvsc.2015.03.025 eng info:eu-repo/semantics/restrictedAccess application/pdf Research in Veterinary Science 100 : 52-60 (June 2015) |