Acinetobacter baumannii and Its relationship to carbapenem resistance : a meta-analysis

Infections by antibiotic-resistant bacteria are a significant and complex global health issue. In this context, Acinetobacter baumannii is particularly important because of its ability to withstand treatments by β-lactams, such as carbapenem. The objective of this work was to investigate, through systematic analysis and meta-analysis, the chance of resistance to carbapenem in A. baumannii strains. For this, a search was conducted for the PubMed and Cochrane databases based on the keywords: “Acinetobacter baumannii” AND “beta-lactam” OR “penicillin” OR “cephalosporin” OR “cephamycin” OR “carbapenem” OR “monobactam”. The initial search resulted in a total of 90,475 articles. It was filtered based on eligibility criteria, and eight articles were selected for analysis. An odds ratio value equivalent to 3.55 was obtained, indicating a high chance of resistance to the carbapenem of strains of the species. Therefore, it is supposed that A. baumannii infection cases have a high probability of not responding adequately to treatments based on carbapenem.

Bibliographic Details

Main Authors:	Rodrigues, Diego Lucas Neres, Costa, Francielly Morais Rodrigues da, Marques Da Silva, Wanderson, Aburjaile, Flavia, Azevedo, Vasco
Format:	info:ar-repo/semantics/artículo biblioteca
Language:	eng
Published:	MDPI 2022-05
Subjects:	Infection, Acinetobacter, Resistance to Antibiotics, Infección, Resistencia a los Antibióticos, Acinetobacter baumannii, Carbapenem,
Online Access:	http://hdl.handle.net/20.500.12123/12648 https://www.mdpi.com/2674-1334/1/2/10 https://doi.org/10.3390/bacteria1020010
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