Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae)
The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide. The sesquiterpene lactones eucannabinolide and santhemoidin C were active on T. cruzi with IC50 values of 10 ± 2 µM (4.2 µg/mL) and 18 ± 3 µM (7.6 µg/mL), respectively. Euparin and santhemoidin C were the most active on L. infantum with IC50 values of 18 ± 4 µM (3.9 µg/mL) and 19 ± 4 µM (8.0 µg/mL), respectively. Eucannabinolide has also shown drug-like pharmacokinetic and toxicity properties.
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Hindawi
2021-02-12
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Subjects: | Urolepis, Actividad, Activity, Antimicrobial Properties, Asteraceae, Propiedades Antimicrobianas, Urolepis hecatantha, |
Online Access: | http://hdl.handle.net/20.500.12123/11763 https://www.hindawi.com/journals/ecam/2021/6622894/ https://doi.org/10.1155/2021/6622894 |
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oai:localhost:20.500.12123-117632024-02-26T12:25:25Z Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae) Elso, Orlando G. Clavin, María Hernandez, Natalia Slargata, Tomás Bach, Hernán Gerónimo Catalan, César A.N. Aguilera, Elena Alvarez, Guzmán Sülsen, Valeria P. Urolepis Actividad Activity Antimicrobial Properties Asteraceae Propiedades Antimicrobianas Urolepis hecatantha The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide. The sesquiterpene lactones eucannabinolide and santhemoidin C were active on T. cruzi with IC50 values of 10 ± 2 µM (4.2 µg/mL) and 18 ± 3 µM (7.6 µg/mL), respectively. Euparin and santhemoidin C were the most active on L. infantum with IC50 values of 18 ± 4 µM (3.9 µg/mL) and 19 ± 4 µM (8.0 µg/mL), respectively. Eucannabinolide has also shown drug-like pharmacokinetic and toxicity properties. Fil: Elso, Orlando G. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentina. CONICET–Universidad de Buenos Aires. Instituto de Química y Metabolismo del Fármaco (IQUIMEFA); Argentina Fil: Clavin, Maria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentina. CONICET–Universidad de Buenos Aires. Instituto de Química y Metabolismo del Fármaco (IQUIMEFA); Argentina Fil: Hernández, Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentina. Fil: Sgarlata, Tomas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentina. Fil: Bach, Hernán Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina Fil: Catalán, César A. N. Universidad Nacional de Tucumán. Facultad de Bioquímica Química y Farmacia. Instituto de Química Orgánica; Argentina Fil: Aguilera, Elena. Universidad de la República. Facultad de Ciencias. Grupo de Química Medicinal. Laboratorio de Química Orgánica; Uruguay Fil: Álvarez, Guzmán. Universidad de la República. CENUR Litoral Norte. Laboratorio de Moléculas Bioactivas; Uruguay Fil: Sulsen, Valeria P. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentina. CONICET–Universidad de Buenos Aires. Instituto de Química y Metabolismo del Fármaco (IQUIMEFA); Argentina 2022-04-29T09:39:06Z 2022-04-29T09:39:06Z 2021-02-12 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/11763 https://www.hindawi.com/journals/ecam/2021/6622894/ 1741-427X 1741-4288 https://doi.org/10.1155/2021/6622894 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Hindawi Evidence based complementary and alternative medicine 2021 : Article ID 6622894 (2021) |
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Urolepis Actividad Activity Antimicrobial Properties Asteraceae Propiedades Antimicrobianas Urolepis hecatantha Urolepis Actividad Activity Antimicrobial Properties Asteraceae Propiedades Antimicrobianas Urolepis hecatantha |
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Urolepis Actividad Activity Antimicrobial Properties Asteraceae Propiedades Antimicrobianas Urolepis hecatantha Urolepis Actividad Activity Antimicrobial Properties Asteraceae Propiedades Antimicrobianas Urolepis hecatantha Elso, Orlando G. Clavin, María Hernandez, Natalia Slargata, Tomás Bach, Hernán Gerónimo Catalan, César A.N. Aguilera, Elena Alvarez, Guzmán Sülsen, Valeria P. Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae) |
description |
The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide. The sesquiterpene lactones eucannabinolide and santhemoidin C were active on T. cruzi with IC50 values of 10 ± 2 µM (4.2 µg/mL) and 18 ± 3 µM (7.6 µg/mL), respectively. Euparin and santhemoidin C were the most active on L. infantum with IC50 values of 18 ± 4 µM (3.9 µg/mL) and 19 ± 4 µM (8.0 µg/mL), respectively. Eucannabinolide has also shown drug-like pharmacokinetic and toxicity properties. |
format |
info:ar-repo/semantics/artículo |
topic_facet |
Urolepis Actividad Activity Antimicrobial Properties Asteraceae Propiedades Antimicrobianas Urolepis hecatantha |
author |
Elso, Orlando G. Clavin, María Hernandez, Natalia Slargata, Tomás Bach, Hernán Gerónimo Catalan, César A.N. Aguilera, Elena Alvarez, Guzmán Sülsen, Valeria P. |
author_facet |
Elso, Orlando G. Clavin, María Hernandez, Natalia Slargata, Tomás Bach, Hernán Gerónimo Catalan, César A.N. Aguilera, Elena Alvarez, Guzmán Sülsen, Valeria P. |
author_sort |
Elso, Orlando G. |
title |
Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae) |
title_short |
Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae) |
title_full |
Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae) |
title_fullStr |
Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae) |
title_full_unstemmed |
Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae) |
title_sort |
antiprotozoal compounds from urolepis hecatantha (asteraceae) |
publisher |
Hindawi |
publishDate |
2021-02-12 |
url |
http://hdl.handle.net/20.500.12123/11763 https://www.hindawi.com/journals/ecam/2021/6622894/ https://doi.org/10.1155/2021/6622894 |
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