Secretion systems of pathogenic escherichia coli
Protein secretion plays a central role in modulating the interactions of bacteria with their environments. Bacterial ribosomes synthesize up to 8000 different proteins. Almost half of these become integrated in membranes and are secreted to the periplasm or to the external milieu. Many bacterial processes , such as DNA replication, motility, transport, antibiotic resistance, scavenging of chemicals, and pathogenesis, depend on protein secretion. Thereby, evolutionarily unrelated protein nanomachines have been developed, which allow exported proteins to cross the Gram-negative membranes. Bacterial proteins can be exported directly from the cytoplasm out of the cell by a one-step (cytoplasm to extracellular milieu), including the type I secretion system (T1SS), T3SS, T4SS, and T6SS, or two-step (periplasm translocation step), including the T2SS and T5SS, while the T4SS can use either the one- or two-step mechanism. The T3SS, T5SS, and T6SS are the more common secretion systems in Escherichia coli and most of the secreted substrates are virulence factors related to pathogenic E. coli . In this chapter, we will describe the main characteristic of these last three secretion systems.
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Springer International Publishing
2016
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Subjects: | Escherichia Coli, Bacteria, Patogenicidad, Bacteria Gram Negativa, Pathogenicity, Gram Negative Bacteria, |
Online Access: | http://hdl.handle.net/20.500.12123/1058 https://link.springer.com/chapter/10.1007%2F978-3-319-45092-6_10 https://doi.org/10.1007/978-3-319-45092-6_10 |
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oai:localhost:20.500.12123-10582019-03-22T13:20:33Z Secretion systems of pathogenic escherichia coli Navarro-García, Fernando Ruiz-Perez, Fernando Larzabal, Mariano Cataldi, Angel Adrian Torres, Alfredo G. (editor) Escherichia Coli Bacteria Patogenicidad Bacteria Gram Negativa Pathogenicity Gram Negative Bacteria Protein secretion plays a central role in modulating the interactions of bacteria with their environments. Bacterial ribosomes synthesize up to 8000 different proteins. Almost half of these become integrated in membranes and are secreted to the periplasm or to the external milieu. Many bacterial processes , such as DNA replication, motility, transport, antibiotic resistance, scavenging of chemicals, and pathogenesis, depend on protein secretion. Thereby, evolutionarily unrelated protein nanomachines have been developed, which allow exported proteins to cross the Gram-negative membranes. Bacterial proteins can be exported directly from the cytoplasm out of the cell by a one-step (cytoplasm to extracellular milieu), including the type I secretion system (T1SS), T3SS, T4SS, and T6SS, or two-step (periplasm translocation step), including the T2SS and T5SS, while the T4SS can use either the one- or two-step mechanism. The T3SS, T5SS, and T6SS are the more common secretion systems in Escherichia coli and most of the secreted substrates are virulence factors related to pathogenic E. coli . In this chapter, we will describe the main characteristic of these last three secretion systems. Inst. de Biotecnología Fil: Navarro-García, Fernando. Instituto Politécnico Nacional. Centro de Investigación y de Estudios Avanzados.Departamento de Biología Celular; México Fil: Ruiz-Perez, Fernando. University of Virginia School of Medicine. Department of Pediatrics; Estados Unidos Fil: Larzabal, Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina 2017-08-28T16:58:47Z 2017-08-28T16:58:47Z 2016 info:ar-repo/semantics/parte de libro info:eu-repo/semantics/bookPart info:eu-repo/semantics/acceptedVersion http://hdl.handle.net/20.500.12123/1058 https://link.springer.com/chapter/10.1007%2F978-3-319-45092-6_10 Navarro-Garcia F., Ruiz-Perez F., Larzábal M., Cataldi A. (2016) Secretion Systems of Pathogenic Escherichia coli. In: Torres A. (eds) Escherichia coli in the Americas. Springer, Cham 978-3-319-45092-6 (Online) 978-3-319-45091-9 (Print) https://doi.org/10.1007/978-3-319-45092-6_10 eng info:eu-repo/semantics/restrictedAccess application/pdf Springer International Publishing Escherichia coli in the Americas / Edited by Alfredo G. Torres. Swizerland : Springer International Publishing, p. 221-249 |
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Escherichia Coli Bacteria Patogenicidad Bacteria Gram Negativa Pathogenicity Gram Negative Bacteria Escherichia Coli Bacteria Patogenicidad Bacteria Gram Negativa Pathogenicity Gram Negative Bacteria |
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Escherichia Coli Bacteria Patogenicidad Bacteria Gram Negativa Pathogenicity Gram Negative Bacteria Escherichia Coli Bacteria Patogenicidad Bacteria Gram Negativa Pathogenicity Gram Negative Bacteria Navarro-García, Fernando Ruiz-Perez, Fernando Larzabal, Mariano Cataldi, Angel Adrian Secretion systems of pathogenic escherichia coli |
description |
Protein secretion plays a central role in modulating the interactions of
bacteria with their environments. Bacterial ribosomes synthesize up to 8000 different proteins. Almost half of these become integrated in membranes and are secreted to the periplasm or to the external milieu. Many bacterial processes , such as DNA replication, motility, transport, antibiotic resistance, scavenging of chemicals, and pathogenesis, depend on protein secretion. Thereby, evolutionarily unrelated protein nanomachines have been developed, which allow exported proteins to cross the Gram-negative membranes. Bacterial proteins can be exported directly from the cytoplasm out of the cell by a one-step (cytoplasm to extracellular milieu), including the type I secretion system (T1SS), T3SS, T4SS, and T6SS, or two-step (periplasm translocation step),
including the T2SS and T5SS, while the T4SS can use either the one- or two-step
mechanism. The T3SS, T5SS, and T6SS are the more common secretion systems in Escherichia coli and most of the secreted substrates are virulence factors related to pathogenic E. coli . In this chapter, we will describe the main characteristic of these last three secretion systems. |
author2 |
Torres, Alfredo G. (editor) |
author_facet |
Torres, Alfredo G. (editor) Navarro-García, Fernando Ruiz-Perez, Fernando Larzabal, Mariano Cataldi, Angel Adrian |
format |
info:ar-repo/semantics/parte de libro |
topic_facet |
Escherichia Coli Bacteria Patogenicidad Bacteria Gram Negativa Pathogenicity Gram Negative Bacteria |
author |
Navarro-García, Fernando Ruiz-Perez, Fernando Larzabal, Mariano Cataldi, Angel Adrian |
author_sort |
Navarro-García, Fernando |
title |
Secretion systems of pathogenic escherichia coli |
title_short |
Secretion systems of pathogenic escherichia coli |
title_full |
Secretion systems of pathogenic escherichia coli |
title_fullStr |
Secretion systems of pathogenic escherichia coli |
title_full_unstemmed |
Secretion systems of pathogenic escherichia coli |
title_sort |
secretion systems of pathogenic escherichia coli |
publisher |
Springer International Publishing |
publishDate |
2016 |
url |
http://hdl.handle.net/20.500.12123/1058 https://link.springer.com/chapter/10.1007%2F978-3-319-45092-6_10 https://doi.org/10.1007/978-3-319-45092-6_10 |
work_keys_str_mv |
AT navarrogarciafernando secretionsystemsofpathogenicescherichiacoli AT ruizperezfernando secretionsystemsofpathogenicescherichiacoli AT larzabalmariano secretionsystemsofpathogenicescherichiacoli AT cataldiangeladrian secretionsystemsofpathogenicescherichiacoli |
_version_ |
1756006959116451841 |