Antihypertensive Effect of Carica papaya Via a Reduction in ACE Activity and Improved Baroreflex.

The aims of this study were to evaluate the antihypertensive effects of the standardised methanolic extract of Carica papaya, its angiotensin converting enzyme inhibitory effects in vivo, its effect on the baroreflex and serum angiotensin converting enzyme activity, and its chemical composition. The chemical composition of the methanolic extract of C. papaya was evaluated by liquid chromatography-mass/mass and mass/mass spectrometry. The angiotensin converting enzyme inhibitory effect was evaluated in vivo by Ang I administration. The antihypertensive assay was performed in spontaneously hypertensive rats and Wistar rats that were treated with enalapril (10 mg/kg), the methanolic extract of C. papaya (100 mg/kg; twice a day), or vehicle for 30 days. The baroreflex was evaluated through the use of sodium nitroprusside and phenylephrine. Angiotensin converting enzyme activity was measured by ELISA, and cardiac hypertrophy was evaluated by morphometric analysis. The methanolic extract of C. papaya was standardised in ferulic acid (203.41 ± 0.02 µg/g), caffeic acid (172.60 ± 0.02 µg/g), gallic acid (145.70 ± 0.02 µg/g), and quercetin (47.11 ± 0.03 µg/g). The flavonoids quercetin, rutin, nicotiflorin, clitorin, and manghaslin were identified in a fraction of the extract. The methanolic extract of C. papaya elicited angiotensin converting enzyme inhibitory activity. The antihypertensive effects elicited by the methanolic extract of C. papaya were similar to those of enalapril, and the baroreflex sensitivity was normalised in treated spontaneously hypertensive rats. Plasma angiotensin converting enzyme activity and cardiac hypertrophy were also reduced to levels comparable to the enalapril-treated group. These results may be associated with the chemical composition of the methanolic extract of C. papaya, and are the first step into the development of a new phytotherapic product which could be used in the treatment of hypertension.

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Main Authors: BRASIL, G. A., RONCHI, S. N., NASCIMENTO, A. M., LIMA, E. M. de., ROMÃO, W., COSTA, H. B. da., SCHERER, R., VENTURA. J. A., LENZ, D., BISSOLI, N. S., ENDRINGER, D. C., ANDRADE, T. U. de.
Other Authors: Girlandia Alexandre Brasil; Silas Nascimento Ronchi; Andrews Marques do Nascimento; Ewelyne Miranda de Lima; Wanderson Romão; Helber Barcellos da Costa; Rodrigo Scherer; Jose Aires Ventura, Incaper; Dominik Lenz; Nazaré Souza Bissoli; Denise Coutinho Endringer; Tadeu Uggere de Andrade.
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Language:English
Published: American Journal of Plant Sciences, 2014, 5, 2148-2153. 2014
Subjects:Rubi INCAPER 511, Carica papaya, Mamão, Antihypertensive, Hypertension,
Online Access:http://biblioteca.incaper.es.gov.br/digital/handle/item/404
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spelling oai:https:--biblioteca.incaper.es.gov.br:item-4042024-11-11T15:45:14Z Antihypertensive Effect of Carica papaya Via a Reduction in ACE Activity and Improved Baroreflex. BRASIL, G. A. RONCHI, S. N. NASCIMENTO, A. M. LIMA, E. M. de. ROMÃO, W. COSTA, H. B. da. SCHERER, R. VENTURA. J. A. LENZ, D. BISSOLI, N. S. ENDRINGER, D. C. ANDRADE, T. U. de. Girlandia Alexandre Brasil; Silas Nascimento Ronchi; Andrews Marques do Nascimento; Ewelyne Miranda de Lima; Wanderson Romão; Helber Barcellos da Costa; Rodrigo Scherer; Jose Aires Ventura, Incaper; Dominik Lenz; Nazaré Souza Bissoli; Denise Coutinho Endringer; Tadeu Uggere de Andrade. Rubi INCAPER 511 Carica papaya Mamão Antihypertensive Hypertension The aims of this study were to evaluate the antihypertensive effects of the standardised methanolic extract of Carica papaya, its angiotensin converting enzyme inhibitory effects in vivo, its effect on the baroreflex and serum angiotensin converting enzyme activity, and its chemical composition. The chemical composition of the methanolic extract of C. papaya was evaluated by liquid chromatography-mass/mass and mass/mass spectrometry. The angiotensin converting enzyme inhibitory effect was evaluated in vivo by Ang I administration. The antihypertensive assay was performed in spontaneously hypertensive rats and Wistar rats that were treated with enalapril (10 mg/kg), the methanolic extract of C. papaya (100 mg/kg; twice a day), or vehicle for 30 days. The baroreflex was evaluated through the use of sodium nitroprusside and phenylephrine. Angiotensin converting enzyme activity was measured by ELISA, and cardiac hypertrophy was evaluated by morphometric analysis. The methanolic extract of C. papaya was standardised in ferulic acid (203.41 ± 0.02 µg/g), caffeic acid (172.60 ± 0.02 µg/g), gallic acid (145.70 ± 0.02 µg/g), and quercetin (47.11 ± 0.03 µg/g). The flavonoids quercetin, rutin, nicotiflorin, clitorin, and manghaslin were identified in a fraction of the extract. The methanolic extract of C. papaya elicited angiotensin converting enzyme inhibitory activity. The antihypertensive effects elicited by the methanolic extract of C. papaya were similar to those of enalapril, and the baroreflex sensitivity was normalised in treated spontaneously hypertensive rats. Plasma angiotensin converting enzyme activity and cardiac hypertrophy were also reduced to levels comparable to the enalapril-treated group. These results may be associated with the chemical composition of the methanolic extract of C. papaya, and are the first step into the development of a new phytotherapic product which could be used in the treatment of hypertension. 2014-12-29T14:34:53Z 2014-12-29T14:34:53Z 2014 2014-12-29 -- 4822 http://biblioteca.incaper.es.gov.br/digital/handle/item/404 10.1055/s-0034-1383122 en Planta Med. 2014 Nov ;80(17):1580-7. American Journal of Plant Sciences, 2014, 5, 2148-2153.
institution INCAPER
collection ALICE
country Brasil
countrycode BR
component Bibliográfico
access En linea
databasecode dig-incaper
tag biblioteca
region America del Sur
libraryname Biblioteca Rui Tendinha de INCAPER
language English
topic Rubi INCAPER 511
Carica papaya
Mamão
Antihypertensive
Hypertension
Rubi INCAPER 511
Carica papaya
Mamão
Antihypertensive
Hypertension
spellingShingle Rubi INCAPER 511
Carica papaya
Mamão
Antihypertensive
Hypertension
Rubi INCAPER 511
Carica papaya
Mamão
Antihypertensive
Hypertension
BRASIL, G. A.
RONCHI, S. N.
NASCIMENTO, A. M.
LIMA, E. M. de.
ROMÃO, W.
COSTA, H. B. da.
SCHERER, R.
VENTURA. J. A.
LENZ, D.
BISSOLI, N. S.
ENDRINGER, D. C.
ANDRADE, T. U. de.
Antihypertensive Effect of Carica papaya Via a Reduction in ACE Activity and Improved Baroreflex.
description The aims of this study were to evaluate the antihypertensive effects of the standardised methanolic extract of Carica papaya, its angiotensin converting enzyme inhibitory effects in vivo, its effect on the baroreflex and serum angiotensin converting enzyme activity, and its chemical composition. The chemical composition of the methanolic extract of C. papaya was evaluated by liquid chromatography-mass/mass and mass/mass spectrometry. The angiotensin converting enzyme inhibitory effect was evaluated in vivo by Ang I administration. The antihypertensive assay was performed in spontaneously hypertensive rats and Wistar rats that were treated with enalapril (10 mg/kg), the methanolic extract of C. papaya (100 mg/kg; twice a day), or vehicle for 30 days. The baroreflex was evaluated through the use of sodium nitroprusside and phenylephrine. Angiotensin converting enzyme activity was measured by ELISA, and cardiac hypertrophy was evaluated by morphometric analysis. The methanolic extract of C. papaya was standardised in ferulic acid (203.41 ± 0.02 µg/g), caffeic acid (172.60 ± 0.02 µg/g), gallic acid (145.70 ± 0.02 µg/g), and quercetin (47.11 ± 0.03 µg/g). The flavonoids quercetin, rutin, nicotiflorin, clitorin, and manghaslin were identified in a fraction of the extract. The methanolic extract of C. papaya elicited angiotensin converting enzyme inhibitory activity. The antihypertensive effects elicited by the methanolic extract of C. papaya were similar to those of enalapril, and the baroreflex sensitivity was normalised in treated spontaneously hypertensive rats. Plasma angiotensin converting enzyme activity and cardiac hypertrophy were also reduced to levels comparable to the enalapril-treated group. These results may be associated with the chemical composition of the methanolic extract of C. papaya, and are the first step into the development of a new phytotherapic product which could be used in the treatment of hypertension.
author2 Girlandia Alexandre Brasil; Silas Nascimento Ronchi; Andrews Marques do Nascimento; Ewelyne Miranda de Lima; Wanderson Romão; Helber Barcellos da Costa; Rodrigo Scherer; Jose Aires Ventura, Incaper; Dominik Lenz; Nazaré Souza Bissoli; Denise Coutinho Endringer; Tadeu Uggere de Andrade.
author_facet Girlandia Alexandre Brasil; Silas Nascimento Ronchi; Andrews Marques do Nascimento; Ewelyne Miranda de Lima; Wanderson Romão; Helber Barcellos da Costa; Rodrigo Scherer; Jose Aires Ventura, Incaper; Dominik Lenz; Nazaré Souza Bissoli; Denise Coutinho Endringer; Tadeu Uggere de Andrade.
BRASIL, G. A.
RONCHI, S. N.
NASCIMENTO, A. M.
LIMA, E. M. de.
ROMÃO, W.
COSTA, H. B. da.
SCHERER, R.
VENTURA. J. A.
LENZ, D.
BISSOLI, N. S.
ENDRINGER, D. C.
ANDRADE, T. U. de.
format --
topic_facet Rubi INCAPER 511
Carica papaya
Mamão
Antihypertensive
Hypertension
author BRASIL, G. A.
RONCHI, S. N.
NASCIMENTO, A. M.
LIMA, E. M. de.
ROMÃO, W.
COSTA, H. B. da.
SCHERER, R.
VENTURA. J. A.
LENZ, D.
BISSOLI, N. S.
ENDRINGER, D. C.
ANDRADE, T. U. de.
author_sort BRASIL, G. A.
title Antihypertensive Effect of Carica papaya Via a Reduction in ACE Activity and Improved Baroreflex.
title_short Antihypertensive Effect of Carica papaya Via a Reduction in ACE Activity and Improved Baroreflex.
title_full Antihypertensive Effect of Carica papaya Via a Reduction in ACE Activity and Improved Baroreflex.
title_fullStr Antihypertensive Effect of Carica papaya Via a Reduction in ACE Activity and Improved Baroreflex.
title_full_unstemmed Antihypertensive Effect of Carica papaya Via a Reduction in ACE Activity and Improved Baroreflex.
title_sort antihypertensive effect of carica papaya via a reduction in ace activity and improved baroreflex.
publisher American Journal of Plant Sciences, 2014, 5, 2148-2153.
publishDate 2014
url http://biblioteca.incaper.es.gov.br/digital/handle/item/404
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