How α -lactalbumin and β –casein level in infant formula influence the protein and minerals absorption properties by using Caco-2 cell model
This study investigated the differences in absorption of infant formula with different levels of α-lactalbumin (α-La) and β-casein (β-CN), and how α-La and β-CN (α+β) affect mineral absorption using the Caco-2 cell model. Compared to the control group, the free amino acid content transported to the basal side significantly increased in the fortification of α-La and β-CN, particularly in the α+β (high) group, which reached 11.343 μmol/L. Furthermore, fortification of α-La and β-CN upregulated the expression of the amino acid transporter SLC6A14 and the oligopeptide transporter PEPT1, in particular the expression of SLC6A14 in the α+β (high) group was 103% of that of the control group. In addition, fortification of α-La and β-CN enhanced the absorption of Ca, Mg, and Zn. The absorption rates of Ca, Mg, and Zn in α+β (high) group increased to 31.27%, 13.66%, and 58.59%, respectively, of which α-La contributed the most on Ca absorption. In conclusion, α-La and β-CN fortification not only increased the absorption of amino acids and peptides but also promoted the absorption of minerals, which provide evidence for the benefits of adjustment of α-La and β-CN in the infant formula.
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article/Letter to editor biblioteca |
Language: | English |
Subjects: | Ca, Caco-2, Infant formula, Mg, Zn, α-lactalbumin, β-casein, |
Online Access: | https://research.wur.nl/en/publications/how-α-lactalbumin-and-β-casein-level-in-infant-formula-influence- |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
dig-wur-nl-wurpubs-629344 |
---|---|
record_format |
koha |
spelling |
dig-wur-nl-wurpubs-6293442024-10-02 Han, Mengyu Wang, Xuemin Zhang, Kai Szeto, Ignatius Man Yau Duan, Sufang Yan, Yalu Liu, Biao Hettinga, Kasper Zhang, Lina Zhou, Peng Article/Letter to editor Food Bioscience 59 (2024) ISSN: 2212-4292 How α -lactalbumin and β –casein level in infant formula influence the protein and minerals absorption properties by using Caco-2 cell model 2024 This study investigated the differences in absorption of infant formula with different levels of α-lactalbumin (α-La) and β-casein (β-CN), and how α-La and β-CN (α+β) affect mineral absorption using the Caco-2 cell model. Compared to the control group, the free amino acid content transported to the basal side significantly increased in the fortification of α-La and β-CN, particularly in the α+β (high) group, which reached 11.343 μmol/L. Furthermore, fortification of α-La and β-CN upregulated the expression of the amino acid transporter SLC6A14 and the oligopeptide transporter PEPT1, in particular the expression of SLC6A14 in the α+β (high) group was 103% of that of the control group. In addition, fortification of α-La and β-CN enhanced the absorption of Ca, Mg, and Zn. The absorption rates of Ca, Mg, and Zn in α+β (high) group increased to 31.27%, 13.66%, and 58.59%, respectively, of which α-La contributed the most on Ca absorption. In conclusion, α-La and β-CN fortification not only increased the absorption of amino acids and peptides but also promoted the absorption of minerals, which provide evidence for the benefits of adjustment of α-La and β-CN in the infant formula. en application/pdf https://research.wur.nl/en/publications/how-α-lactalbumin-and-β-casein-level-in-infant-formula-influence- 10.1016/j.fbio.2024.103948 https://edepot.wur.nl/656859 Ca Caco-2 Infant formula Mg Zn α-lactalbumin β-casein Wageningen University & Research |
institution |
WUR NL |
collection |
DSpace |
country |
Países bajos |
countrycode |
NL |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-wur-nl |
tag |
biblioteca |
region |
Europa del Oeste |
libraryname |
WUR Library Netherlands |
language |
English |
topic |
Ca Caco-2 Infant formula Mg Zn α-lactalbumin β-casein Ca Caco-2 Infant formula Mg Zn α-lactalbumin β-casein |
spellingShingle |
Ca Caco-2 Infant formula Mg Zn α-lactalbumin β-casein Ca Caco-2 Infant formula Mg Zn α-lactalbumin β-casein Han, Mengyu Wang, Xuemin Zhang, Kai Szeto, Ignatius Man Yau Duan, Sufang Yan, Yalu Liu, Biao Hettinga, Kasper Zhang, Lina Zhou, Peng How α -lactalbumin and β –casein level in infant formula influence the protein and minerals absorption properties by using Caco-2 cell model |
description |
This study investigated the differences in absorption of infant formula with different levels of α-lactalbumin (α-La) and β-casein (β-CN), and how α-La and β-CN (α+β) affect mineral absorption using the Caco-2 cell model. Compared to the control group, the free amino acid content transported to the basal side significantly increased in the fortification of α-La and β-CN, particularly in the α+β (high) group, which reached 11.343 μmol/L. Furthermore, fortification of α-La and β-CN upregulated the expression of the amino acid transporter SLC6A14 and the oligopeptide transporter PEPT1, in particular the expression of SLC6A14 in the α+β (high) group was 103% of that of the control group. In addition, fortification of α-La and β-CN enhanced the absorption of Ca, Mg, and Zn. The absorption rates of Ca, Mg, and Zn in α+β (high) group increased to 31.27%, 13.66%, and 58.59%, respectively, of which α-La contributed the most on Ca absorption. In conclusion, α-La and β-CN fortification not only increased the absorption of amino acids and peptides but also promoted the absorption of minerals, which provide evidence for the benefits of adjustment of α-La and β-CN in the infant formula. |
format |
Article/Letter to editor |
topic_facet |
Ca Caco-2 Infant formula Mg Zn α-lactalbumin β-casein |
author |
Han, Mengyu Wang, Xuemin Zhang, Kai Szeto, Ignatius Man Yau Duan, Sufang Yan, Yalu Liu, Biao Hettinga, Kasper Zhang, Lina Zhou, Peng |
author_facet |
Han, Mengyu Wang, Xuemin Zhang, Kai Szeto, Ignatius Man Yau Duan, Sufang Yan, Yalu Liu, Biao Hettinga, Kasper Zhang, Lina Zhou, Peng |
author_sort |
Han, Mengyu |
title |
How α -lactalbumin and β –casein level in infant formula influence the protein and minerals absorption properties by using Caco-2 cell model |
title_short |
How α -lactalbumin and β –casein level in infant formula influence the protein and minerals absorption properties by using Caco-2 cell model |
title_full |
How α -lactalbumin and β –casein level in infant formula influence the protein and minerals absorption properties by using Caco-2 cell model |
title_fullStr |
How α -lactalbumin and β –casein level in infant formula influence the protein and minerals absorption properties by using Caco-2 cell model |
title_full_unstemmed |
How α -lactalbumin and β –casein level in infant formula influence the protein and minerals absorption properties by using Caco-2 cell model |
title_sort |
how α -lactalbumin and β –casein level in infant formula influence the protein and minerals absorption properties by using caco-2 cell model |
url |
https://research.wur.nl/en/publications/how-α-lactalbumin-and-β-casein-level-in-infant-formula-influence- |
work_keys_str_mv |
AT hanmengyu howalactalbuminandbcaseinlevelininfantformulainfluencetheproteinandmineralsabsorptionpropertiesbyusingcaco2cellmodel AT wangxuemin howalactalbuminandbcaseinlevelininfantformulainfluencetheproteinandmineralsabsorptionpropertiesbyusingcaco2cellmodel AT zhangkai howalactalbuminandbcaseinlevelininfantformulainfluencetheproteinandmineralsabsorptionpropertiesbyusingcaco2cellmodel AT szetoignatiusmanyau howalactalbuminandbcaseinlevelininfantformulainfluencetheproteinandmineralsabsorptionpropertiesbyusingcaco2cellmodel AT duansufang howalactalbuminandbcaseinlevelininfantformulainfluencetheproteinandmineralsabsorptionpropertiesbyusingcaco2cellmodel AT yanyalu howalactalbuminandbcaseinlevelininfantformulainfluencetheproteinandmineralsabsorptionpropertiesbyusingcaco2cellmodel AT liubiao howalactalbuminandbcaseinlevelininfantformulainfluencetheproteinandmineralsabsorptionpropertiesbyusingcaco2cellmodel AT hettingakasper howalactalbuminandbcaseinlevelininfantformulainfluencetheproteinandmineralsabsorptionpropertiesbyusingcaco2cellmodel AT zhanglina howalactalbuminandbcaseinlevelininfantformulainfluencetheproteinandmineralsabsorptionpropertiesbyusingcaco2cellmodel AT zhoupeng howalactalbuminandbcaseinlevelininfantformulainfluencetheproteinandmineralsabsorptionpropertiesbyusingcaco2cellmodel |
_version_ |
1813192090833649664 |