Rise of the RNA machines – self-amplification in mRNA vaccine design
mRNA vaccines have won the race for early COVID-19 vaccine approval, yet improvements are necessary to retain this leading role in combating infectious diseases. A next generation of self-amplifying mRNAs, also known as replicons, form an ideal vaccine platform. Replicons induce potent humoral and cellular responses with few adverse effects upon a minimal, single-dose immunization. Delivery of replicons is achieved with virus-like replicon particles (VRPs), or in nonviral vehicles such as liposomes or lipid nanoparticles. Here, we discuss innovative advances, including multivalent, mucosal, and therapeutic replicon vaccines, and highlight novelties in replicon design. As soon as essential safety evaluations have been resolved, this promising vaccine concept can transform into a widely applied clinical platform technology taking center stage in pandemic preparedness.
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| Format: | Article/Letter to editor biblioteca |
| Language: | English |
| Subjects: | lipid nanoparticles, mRNA, platform technology, replicon, self-amplifying RNA, vaccines, |
| Online Access: | https://research.wur.nl/en/publications/rise-of-the-rna-machines-self-amplification-in-mrna-vaccine-desig |
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dig-wur-nl-wurpubs-6170852024-12-04 Comes, Jerome D.G. Pijlman, Gorben P. Hick, Tessy A.H. Article/Letter to editor Trends in Biotechnology 41 (2023) 11 ISSN: 0167-7799 Rise of the RNA machines – self-amplification in mRNA vaccine design 2023 mRNA vaccines have won the race for early COVID-19 vaccine approval, yet improvements are necessary to retain this leading role in combating infectious diseases. A next generation of self-amplifying mRNAs, also known as replicons, form an ideal vaccine platform. Replicons induce potent humoral and cellular responses with few adverse effects upon a minimal, single-dose immunization. Delivery of replicons is achieved with virus-like replicon particles (VRPs), or in nonviral vehicles such as liposomes or lipid nanoparticles. Here, we discuss innovative advances, including multivalent, mucosal, and therapeutic replicon vaccines, and highlight novelties in replicon design. As soon as essential safety evaluations have been resolved, this promising vaccine concept can transform into a widely applied clinical platform technology taking center stage in pandemic preparedness. en application/pdf https://research.wur.nl/en/publications/rise-of-the-rna-machines-self-amplification-in-mrna-vaccine-desig 10.1016/j.tibtech.2023.05.007 https://edepot.wur.nl/635299 lipid nanoparticles mRNA platform technology replicon self-amplifying RNA vaccines https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/ Wageningen University & Research |
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lipid nanoparticles mRNA platform technology replicon self-amplifying RNA vaccines lipid nanoparticles mRNA platform technology replicon self-amplifying RNA vaccines |
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lipid nanoparticles mRNA platform technology replicon self-amplifying RNA vaccines lipid nanoparticles mRNA platform technology replicon self-amplifying RNA vaccines Comes, Jerome D.G. Pijlman, Gorben P. Hick, Tessy A.H. Rise of the RNA machines – self-amplification in mRNA vaccine design |
| description |
mRNA vaccines have won the race for early COVID-19 vaccine approval, yet improvements are necessary to retain this leading role in combating infectious diseases. A next generation of self-amplifying mRNAs, also known as replicons, form an ideal vaccine platform. Replicons induce potent humoral and cellular responses with few adverse effects upon a minimal, single-dose immunization. Delivery of replicons is achieved with virus-like replicon particles (VRPs), or in nonviral vehicles such as liposomes or lipid nanoparticles. Here, we discuss innovative advances, including multivalent, mucosal, and therapeutic replicon vaccines, and highlight novelties in replicon design. As soon as essential safety evaluations have been resolved, this promising vaccine concept can transform into a widely applied clinical platform technology taking center stage in pandemic preparedness. |
| format |
Article/Letter to editor |
| topic_facet |
lipid nanoparticles mRNA platform technology replicon self-amplifying RNA vaccines |
| author |
Comes, Jerome D.G. Pijlman, Gorben P. Hick, Tessy A.H. |
| author_facet |
Comes, Jerome D.G. Pijlman, Gorben P. Hick, Tessy A.H. |
| author_sort |
Comes, Jerome D.G. |
| title |
Rise of the RNA machines – self-amplification in mRNA vaccine design |
| title_short |
Rise of the RNA machines – self-amplification in mRNA vaccine design |
| title_full |
Rise of the RNA machines – self-amplification in mRNA vaccine design |
| title_fullStr |
Rise of the RNA machines – self-amplification in mRNA vaccine design |
| title_full_unstemmed |
Rise of the RNA machines – self-amplification in mRNA vaccine design |
| title_sort |
rise of the rna machines – self-amplification in mrna vaccine design |
| url |
https://research.wur.nl/en/publications/rise-of-the-rna-machines-self-amplification-in-mrna-vaccine-desig |
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