Differential effects of Akkermansia-enriched fecal microbiota transplant on energy balance in female mice on high-fat diet

Estrogens protect against weight gain and metabolic disruption in women and female rodents. Aberrations in the gut microbiota composition are linked to obesity and metabolic disorders. Furthermore, estrogen-mediated protection against diet-induced metabolic disruption is associated with modifications in gut microbiota. In this study, we tested if estradiol (E2)-mediated protection against obesity and metabolic disorders in female mice is dependent on gut microbiota. Specifically, we tested if fecal microbiota transplantation (FMT) from E2-treated lean female mice, supplemented with or without Akkermansia muciniphila, prevented high fat diet (HFD)-induced body weight gain, fat mass gain, and hyperglycemia in female recipients. FMT from, and cohousing with, E2-treated lean donors was not sufficient to transfer the metabolic benefits to the E2-deficient female recipients. Moreover, FMT from lean donors supplemented with A. muciniphila exacerbated HFD-induced hyperglycemia in E2-deficient recipients, suggesting its detrimental effect on the metabolic health of E2-deficient female rodents fed a HFD. Given that A. muciniphila attenuates HFD-induced metabolic insults in males, the present findings suggest a sex difference in the impact of this microbe on metabolic health.

Bibliographic Details

Main Authors:	Acharya, Kalpana D., Friedline, Randall H., Ward, Doyle V., Graham, Madeline E., Tauer, Lauren, Zheng, Doris, Hu, Xiaodi, de Vos, Willem M., McCormick, Beth A., Kim, Jason K., Tetel, Marc J.
Format:	Article/Letter to editor biblioteca
Language:	English
Subjects:	diabetes, estradiol, estrogens, gut microbiome, metabolism, obesity,
Online Access:	https://research.wur.nl/en/publications/differential-effects-of-akkermansia-enriched-fecal-microbiota-tra
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