The Minimum Information About A Biosynthetic Gene Cluster Standard as a Means of Organizing Bioinformatic Data

Therapeutic agents play an increasingly large role in our daily lives, and it is important to study the source of these powerful chemical compounds. Biosynthetic gene clusters found in a diverse set of organisms are capable of manufacturing structurally complex organic compounds in a systematic way, by expressing suites of a enzymes to build the natural products. There is a growing need for a centralized database to connect data for related genes, enzymes, and compounds. This information is currently stored in a siloed fashion, across several repositories, creating an obstacle for modern researchers. The Minimum Information about a Biosynthetic Gene cluster (MIBiG) database aims to solve this problem by utilizing user-inputted data to translate scientific discoveries into a format that can be analyzed computationally to connect genes to chemistry, understand biosynthetic gene clusters in the context of environmental diversity, and develop computer-generated gene cluster engineering. As an effort to make MiBIG more accessible to an expanding scientific community, we developed a workflow, Excel templates, a tutorial video, a collection of review literature, and educational tools to facilitate the entry process have all been developed. To verify the effectiveness of the protocol and associated resources, MIBiG was deployed as a course-based undergraduate research experience (CURE) in an upper-level undergraduate course.

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Main Authors: Epstein, Samuel C., Medema, Marnix H., Charkoudian, Louise K.
Format: Article/Letter to editor biblioteca
Language:English
Subjects:Life Science,
Online Access:https://research.wur.nl/en/publications/the-minimum-information-about-a-biosynthetic-gene-cluster-standar
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spelling dig-wur-nl-wurpubs-6006322024-09-23 Epstein, Samuel C. Medema, Marnix H. Charkoudian, Louise K. Article/Letter to editor FASEB Journal 32 (2018) S1 ISSN: 0892-6638 The Minimum Information About A Biosynthetic Gene Cluster Standard as a Means of Organizing Bioinformatic Data 2018 Therapeutic agents play an increasingly large role in our daily lives, and it is important to study the source of these powerful chemical compounds. Biosynthetic gene clusters found in a diverse set of organisms are capable of manufacturing structurally complex organic compounds in a systematic way, by expressing suites of a enzymes to build the natural products. There is a growing need for a centralized database to connect data for related genes, enzymes, and compounds. This information is currently stored in a siloed fashion, across several repositories, creating an obstacle for modern researchers. The Minimum Information about a Biosynthetic Gene cluster (MIBiG) database aims to solve this problem by utilizing user-inputted data to translate scientific discoveries into a format that can be analyzed computationally to connect genes to chemistry, understand biosynthetic gene clusters in the context of environmental diversity, and develop computer-generated gene cluster engineering. As an effort to make MiBIG more accessible to an expanding scientific community, we developed a workflow, Excel templates, a tutorial video, a collection of review literature, and educational tools to facilitate the entry process have all been developed. To verify the effectiveness of the protocol and associated resources, MIBiG was deployed as a course-based undergraduate research experience (CURE) in an upper-level undergraduate course. en text/html https://research.wur.nl/en/publications/the-minimum-information-about-a-biosynthetic-gene-cluster-standar 10.1096/fasebj.2018.32.1_supplement.547.2 https://edepot.wur.nl/575110 Life Science (c) publisher Wageningen University & Research
institution WUR NL
collection DSpace
country Países bajos
countrycode NL
component Bibliográfico
access En linea
databasecode dig-wur-nl
tag biblioteca
region Europa del Oeste
libraryname WUR Library Netherlands
language English
topic Life Science
Life Science
spellingShingle Life Science
Life Science
Epstein, Samuel C.
Medema, Marnix H.
Charkoudian, Louise K.
The Minimum Information About A Biosynthetic Gene Cluster Standard as a Means of Organizing Bioinformatic Data
description Therapeutic agents play an increasingly large role in our daily lives, and it is important to study the source of these powerful chemical compounds. Biosynthetic gene clusters found in a diverse set of organisms are capable of manufacturing structurally complex organic compounds in a systematic way, by expressing suites of a enzymes to build the natural products. There is a growing need for a centralized database to connect data for related genes, enzymes, and compounds. This information is currently stored in a siloed fashion, across several repositories, creating an obstacle for modern researchers. The Minimum Information about a Biosynthetic Gene cluster (MIBiG) database aims to solve this problem by utilizing user-inputted data to translate scientific discoveries into a format that can be analyzed computationally to connect genes to chemistry, understand biosynthetic gene clusters in the context of environmental diversity, and develop computer-generated gene cluster engineering. As an effort to make MiBIG more accessible to an expanding scientific community, we developed a workflow, Excel templates, a tutorial video, a collection of review literature, and educational tools to facilitate the entry process have all been developed. To verify the effectiveness of the protocol and associated resources, MIBiG was deployed as a course-based undergraduate research experience (CURE) in an upper-level undergraduate course.
format Article/Letter to editor
topic_facet Life Science
author Epstein, Samuel C.
Medema, Marnix H.
Charkoudian, Louise K.
author_facet Epstein, Samuel C.
Medema, Marnix H.
Charkoudian, Louise K.
author_sort Epstein, Samuel C.
title The Minimum Information About A Biosynthetic Gene Cluster Standard as a Means of Organizing Bioinformatic Data
title_short The Minimum Information About A Biosynthetic Gene Cluster Standard as a Means of Organizing Bioinformatic Data
title_full The Minimum Information About A Biosynthetic Gene Cluster Standard as a Means of Organizing Bioinformatic Data
title_fullStr The Minimum Information About A Biosynthetic Gene Cluster Standard as a Means of Organizing Bioinformatic Data
title_full_unstemmed The Minimum Information About A Biosynthetic Gene Cluster Standard as a Means of Organizing Bioinformatic Data
title_sort minimum information about a biosynthetic gene cluster standard as a means of organizing bioinformatic data
url https://research.wur.nl/en/publications/the-minimum-information-about-a-biosynthetic-gene-cluster-standar
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