An observational study to evaluate the association between intestinal permeability, leaky gut related markers, and metabolic health in healthy adults
We explored whether metabolic health is linked to intestinal permeability, using a multi-sugar (MS) permeability test, and whether intestinal permeability is correlated with the leaky gut-related markers (LGM) zonulin, LBP, and sCD14. Metabolically healthy (n = 15) and unhealthy subjects (n = 15) were recruited based on waist circumference, fasting glucose, and high-density lipoprotein cholesterol levels. Participants underwent an MS permeability test that assessed site-specific permeabilities of the gastroduodenum and small and large intestines. The test was performed with/without an acetylsalicylic acid challenge to measure and correlate the gut permeability, LGM, and metabolic health. At baseline, metabolic health showed no correlation with gut permeability. Significant correlations were found between the metabolic health parameters and LGM. In the acetyl-salicylic acid challenged MS permeability test, low-density lipoprotein cholesterol was correlated with the sucralose/erythritol ratio, reflecting the whole intestinal permeability. Correlations between most metabolic health parameters and LGM during the acetylsalicylic acid challenge were less pronounced than at baseline. In both MS permeability tests, no significant correlations were found between LGM (plasma and serum) and gut permeability. Thus, correlations between LGM and metabolic health might not be linked with paracellular gut permeability. Transcellular translocation and/or lipoprotein-related transportation is a more likely mechanism underlying the association between LGM and metabolic health.
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| Format: | Article/Letter to editor biblioteca |
| Language: | English |
| Subjects: | Intestinal permeability, Leaky gut, Metabolic, Multi-sugar, |
| Online Access: | https://research.wur.nl/en/publications/an-observational-study-to-evaluate-the-association-between-intest |
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dig-wur-nl-wurpubs-5904322025-01-14 Hoshiko, Hiroyuki Zeinstra, Gertrude G. Lenaerts, Kaatje Oosterink, Els Ariens, Renata M.C. Mes, Jurriaan J. de Wit, Nicole J.W. Article/Letter to editor Healthcare (Switzerland) 9 (2021) 11 ISSN: 2227-9032 An observational study to evaluate the association between intestinal permeability, leaky gut related markers, and metabolic health in healthy adults 2021 We explored whether metabolic health is linked to intestinal permeability, using a multi-sugar (MS) permeability test, and whether intestinal permeability is correlated with the leaky gut-related markers (LGM) zonulin, LBP, and sCD14. Metabolically healthy (n = 15) and unhealthy subjects (n = 15) were recruited based on waist circumference, fasting glucose, and high-density lipoprotein cholesterol levels. Participants underwent an MS permeability test that assessed site-specific permeabilities of the gastroduodenum and small and large intestines. The test was performed with/without an acetylsalicylic acid challenge to measure and correlate the gut permeability, LGM, and metabolic health. At baseline, metabolic health showed no correlation with gut permeability. Significant correlations were found between the metabolic health parameters and LGM. In the acetyl-salicylic acid challenged MS permeability test, low-density lipoprotein cholesterol was correlated with the sucralose/erythritol ratio, reflecting the whole intestinal permeability. Correlations between most metabolic health parameters and LGM during the acetylsalicylic acid challenge were less pronounced than at baseline. In both MS permeability tests, no significant correlations were found between LGM (plasma and serum) and gut permeability. Thus, correlations between LGM and metabolic health might not be linked with paracellular gut permeability. Transcellular translocation and/or lipoprotein-related transportation is a more likely mechanism underlying the association between LGM and metabolic health. en application/pdf https://research.wur.nl/en/publications/an-observational-study-to-evaluate-the-association-between-intest 10.3390/healthcare9111583 https://edepot.wur.nl/559140 Intestinal permeability Leaky gut Metabolic Multi-sugar https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/ Wageningen University & Research |
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Intestinal permeability Leaky gut Metabolic Multi-sugar Intestinal permeability Leaky gut Metabolic Multi-sugar |
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Intestinal permeability Leaky gut Metabolic Multi-sugar Intestinal permeability Leaky gut Metabolic Multi-sugar Hoshiko, Hiroyuki Zeinstra, Gertrude G. Lenaerts, Kaatje Oosterink, Els Ariens, Renata M.C. Mes, Jurriaan J. de Wit, Nicole J.W. An observational study to evaluate the association between intestinal permeability, leaky gut related markers, and metabolic health in healthy adults |
| description |
We explored whether metabolic health is linked to intestinal permeability, using a multi-sugar (MS) permeability test, and whether intestinal permeability is correlated with the leaky gut-related markers (LGM) zonulin, LBP, and sCD14. Metabolically healthy (n = 15) and unhealthy subjects (n = 15) were recruited based on waist circumference, fasting glucose, and high-density lipoprotein cholesterol levels. Participants underwent an MS permeability test that assessed site-specific permeabilities of the gastroduodenum and small and large intestines. The test was performed with/without an acetylsalicylic acid challenge to measure and correlate the gut permeability, LGM, and metabolic health. At baseline, metabolic health showed no correlation with gut permeability. Significant correlations were found between the metabolic health parameters and LGM. In the acetyl-salicylic acid challenged MS permeability test, low-density lipoprotein cholesterol was correlated with the sucralose/erythritol ratio, reflecting the whole intestinal permeability. Correlations between most metabolic health parameters and LGM during the acetylsalicylic acid challenge were less pronounced than at baseline. In both MS permeability tests, no significant correlations were found between LGM (plasma and serum) and gut permeability. Thus, correlations between LGM and metabolic health might not be linked with paracellular gut permeability. Transcellular translocation and/or lipoprotein-related transportation is a more likely mechanism underlying the association between LGM and metabolic health. |
| format |
Article/Letter to editor |
| topic_facet |
Intestinal permeability Leaky gut Metabolic Multi-sugar |
| author |
Hoshiko, Hiroyuki Zeinstra, Gertrude G. Lenaerts, Kaatje Oosterink, Els Ariens, Renata M.C. Mes, Jurriaan J. de Wit, Nicole J.W. |
| author_facet |
Hoshiko, Hiroyuki Zeinstra, Gertrude G. Lenaerts, Kaatje Oosterink, Els Ariens, Renata M.C. Mes, Jurriaan J. de Wit, Nicole J.W. |
| author_sort |
Hoshiko, Hiroyuki |
| title |
An observational study to evaluate the association between intestinal permeability, leaky gut related markers, and metabolic health in healthy adults |
| title_short |
An observational study to evaluate the association between intestinal permeability, leaky gut related markers, and metabolic health in healthy adults |
| title_full |
An observational study to evaluate the association between intestinal permeability, leaky gut related markers, and metabolic health in healthy adults |
| title_fullStr |
An observational study to evaluate the association between intestinal permeability, leaky gut related markers, and metabolic health in healthy adults |
| title_full_unstemmed |
An observational study to evaluate the association between intestinal permeability, leaky gut related markers, and metabolic health in healthy adults |
| title_sort |
observational study to evaluate the association between intestinal permeability, leaky gut related markers, and metabolic health in healthy adults |
| url |
https://research.wur.nl/en/publications/an-observational-study-to-evaluate-the-association-between-intest |
| work_keys_str_mv |
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1822266131336921088 |