The Evolutionary Dynamics of Genetic Incompatibilities Introduced by Duplicated Genes in Arabidopsis thaliana
Although gene duplications provide genetic backup and allow genomic changes under relaxed selection, they may potentially limit gene flow. When different copies of a duplicated gene are pseudofunctionalized in different genotypes, genetic incompatibilities can arise in their hybrid offspring. Although such cases have been reported after manual crosses, it remains unclear whether they occur in nature and how they affect natural populations. Here, we identified four duplicated-gene based incompatibilities including one previously not reported within an artificial Arabidopsis intercross population. Unexpectedly, however, for each of the genetic incompatibilities we also identified the incompatible alleles in natural populations based on the genomes of 1,135 Arabidopsis accessions published by the 1001 Genomes Project. Using the presence of incompatible allele combinations as phenotypes for GWAS, we mapped genomic regions that included additional gene copies which likely rescue the genetic incompatibility. Reconstructing the geographic origins and evolutionary trajectories of the individual alleles suggested that incompatible alleles frequently coexist, even in geographically closed regions, and that their effects can be overcome by additional gene copies collectively shaping the evolutionary dynamics of duplicated genes during population history.
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| Format: | Article/Letter to editor biblioteca |
| Language: | English |
| Subjects: | HPA, TIM22, duplicated gene, genetic incompatibility, genome-wide association study, loss of function, |
| Online Access: | https://research.wur.nl/en/publications/the-evolutionary-dynamics-of-genetic-incompatibilities-introduced |
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dig-wur-nl-wurpubs-5823912024-10-30 Jiao, Wen Biao Patel, Vipul Klasen, Jonas Liu, Fang Pecinkova, Petra Ferrand, Marina Gy, Isabelle Camilleri, Christine Effgen, Sigi Koornneef, Maarten Pecinka, Ales Loudet, Olivier Schneeberger, Korbinian Article/Letter to editor Molecular Biology and Evolution 38 (2021) 4 ISSN: 0737-4038 The Evolutionary Dynamics of Genetic Incompatibilities Introduced by Duplicated Genes in Arabidopsis thaliana 2021 Although gene duplications provide genetic backup and allow genomic changes under relaxed selection, they may potentially limit gene flow. When different copies of a duplicated gene are pseudofunctionalized in different genotypes, genetic incompatibilities can arise in their hybrid offspring. Although such cases have been reported after manual crosses, it remains unclear whether they occur in nature and how they affect natural populations. Here, we identified four duplicated-gene based incompatibilities including one previously not reported within an artificial Arabidopsis intercross population. Unexpectedly, however, for each of the genetic incompatibilities we also identified the incompatible alleles in natural populations based on the genomes of 1,135 Arabidopsis accessions published by the 1001 Genomes Project. Using the presence of incompatible allele combinations as phenotypes for GWAS, we mapped genomic regions that included additional gene copies which likely rescue the genetic incompatibility. Reconstructing the geographic origins and evolutionary trajectories of the individual alleles suggested that incompatible alleles frequently coexist, even in geographically closed regions, and that their effects can be overcome by additional gene copies collectively shaping the evolutionary dynamics of duplicated genes during population history. en application/pdf https://research.wur.nl/en/publications/the-evolutionary-dynamics-of-genetic-incompatibilities-introduced 10.1093/molbev/msaa306 https://edepot.wur.nl/546858 HPA TIM22 duplicated gene genetic incompatibility genome-wide association study loss of function https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/ Wageningen University & Research |
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HPA TIM22 duplicated gene genetic incompatibility genome-wide association study loss of function HPA TIM22 duplicated gene genetic incompatibility genome-wide association study loss of function |
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HPA TIM22 duplicated gene genetic incompatibility genome-wide association study loss of function HPA TIM22 duplicated gene genetic incompatibility genome-wide association study loss of function Jiao, Wen Biao Patel, Vipul Klasen, Jonas Liu, Fang Pecinkova, Petra Ferrand, Marina Gy, Isabelle Camilleri, Christine Effgen, Sigi Koornneef, Maarten Pecinka, Ales Loudet, Olivier Schneeberger, Korbinian The Evolutionary Dynamics of Genetic Incompatibilities Introduced by Duplicated Genes in Arabidopsis thaliana |
| description |
Although gene duplications provide genetic backup and allow genomic changes under relaxed selection, they may potentially limit gene flow. When different copies of a duplicated gene are pseudofunctionalized in different genotypes, genetic incompatibilities can arise in their hybrid offspring. Although such cases have been reported after manual crosses, it remains unclear whether they occur in nature and how they affect natural populations. Here, we identified four duplicated-gene based incompatibilities including one previously not reported within an artificial Arabidopsis intercross population. Unexpectedly, however, for each of the genetic incompatibilities we also identified the incompatible alleles in natural populations based on the genomes of 1,135 Arabidopsis accessions published by the 1001 Genomes Project. Using the presence of incompatible allele combinations as phenotypes for GWAS, we mapped genomic regions that included additional gene copies which likely rescue the genetic incompatibility. Reconstructing the geographic origins and evolutionary trajectories of the individual alleles suggested that incompatible alleles frequently coexist, even in geographically closed regions, and that their effects can be overcome by additional gene copies collectively shaping the evolutionary dynamics of duplicated genes during population history. |
| format |
Article/Letter to editor |
| topic_facet |
HPA TIM22 duplicated gene genetic incompatibility genome-wide association study loss of function |
| author |
Jiao, Wen Biao Patel, Vipul Klasen, Jonas Liu, Fang Pecinkova, Petra Ferrand, Marina Gy, Isabelle Camilleri, Christine Effgen, Sigi Koornneef, Maarten Pecinka, Ales Loudet, Olivier Schneeberger, Korbinian |
| author_facet |
Jiao, Wen Biao Patel, Vipul Klasen, Jonas Liu, Fang Pecinkova, Petra Ferrand, Marina Gy, Isabelle Camilleri, Christine Effgen, Sigi Koornneef, Maarten Pecinka, Ales Loudet, Olivier Schneeberger, Korbinian |
| author_sort |
Jiao, Wen Biao |
| title |
The Evolutionary Dynamics of Genetic Incompatibilities Introduced by Duplicated Genes in Arabidopsis thaliana |
| title_short |
The Evolutionary Dynamics of Genetic Incompatibilities Introduced by Duplicated Genes in Arabidopsis thaliana |
| title_full |
The Evolutionary Dynamics of Genetic Incompatibilities Introduced by Duplicated Genes in Arabidopsis thaliana |
| title_fullStr |
The Evolutionary Dynamics of Genetic Incompatibilities Introduced by Duplicated Genes in Arabidopsis thaliana |
| title_full_unstemmed |
The Evolutionary Dynamics of Genetic Incompatibilities Introduced by Duplicated Genes in Arabidopsis thaliana |
| title_sort |
evolutionary dynamics of genetic incompatibilities introduced by duplicated genes in arabidopsis thaliana |
| url |
https://research.wur.nl/en/publications/the-evolutionary-dynamics-of-genetic-incompatibilities-introduced |
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