Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy
Immune-globulin E (IgE)-mediated food allergy is characterized by a variety of clinical entities within the gastrointestinal tract, skin and lungs, and systemically as anaphylaxis. The default response to food antigens, which is antigen specific immune tolerance, requires exposure to the antigen and is already initiated during pregnancy. After birth, tolerance is mostly acquired in the gut after oral ingestion of dietary proteins, whilst exposure to these same proteins via the skin, especially when it is inflamed and has a disrupted barrier, can lead to allergic sensitization. The crosstalk between the skin and the gut, which is involved in the induction of food allergy, is still incompletely understood. In this review, we will focus on mechanisms underlying allergic sensitization (to food antigens) via the skin, leading to gastrointestinal inflammation, and the development of IgE-mediated food allergy. Better understanding of these processes will eventually help to develop new preventive and therapeutic strategies in children.
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Format: | Article/Letter to editor biblioteca |
Language: | English |
Subjects: | Atopic dermatitis, Cutaneous sensitization, Food allergy, Microbiota, Skin-gut-axis, |
Online Access: | https://research.wur.nl/en/publications/mechanisms-underlying-the-skin-gut-cross-talk-in-the-development- |
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dig-wur-nl-wurpubs-5748052024-12-04 van Splunter, M.E. Liu, Liu van Neerven, Joost Wichers, H.J. Hettinga, K.A. De Jong, Nicolette W. Article/Letter to editor Nutrients 12 (2020) 12 ISSN: 2072-6643 Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy 2020 Immune-globulin E (IgE)-mediated food allergy is characterized by a variety of clinical entities within the gastrointestinal tract, skin and lungs, and systemically as anaphylaxis. The default response to food antigens, which is antigen specific immune tolerance, requires exposure to the antigen and is already initiated during pregnancy. After birth, tolerance is mostly acquired in the gut after oral ingestion of dietary proteins, whilst exposure to these same proteins via the skin, especially when it is inflamed and has a disrupted barrier, can lead to allergic sensitization. The crosstalk between the skin and the gut, which is involved in the induction of food allergy, is still incompletely understood. In this review, we will focus on mechanisms underlying allergic sensitization (to food antigens) via the skin, leading to gastrointestinal inflammation, and the development of IgE-mediated food allergy. Better understanding of these processes will eventually help to develop new preventive and therapeutic strategies in children. en text/html https://research.wur.nl/en/publications/mechanisms-underlying-the-skin-gut-cross-talk-in-the-development- 10.3390/nu12123830 https://edepot.wur.nl/537310 Atopic dermatitis Cutaneous sensitization Food allergy Microbiota Skin-gut-axis https://creativecommons.org/licenses/by/4.0/ Wageningen University & Research |
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Atopic dermatitis Cutaneous sensitization Food allergy Microbiota Skin-gut-axis Atopic dermatitis Cutaneous sensitization Food allergy Microbiota Skin-gut-axis |
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Atopic dermatitis Cutaneous sensitization Food allergy Microbiota Skin-gut-axis Atopic dermatitis Cutaneous sensitization Food allergy Microbiota Skin-gut-axis van Splunter, M.E. Liu, Liu van Neerven, Joost Wichers, H.J. Hettinga, K.A. De Jong, Nicolette W. Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy |
description |
Immune-globulin E (IgE)-mediated food allergy is characterized by a variety of clinical entities within the gastrointestinal tract, skin and lungs, and systemically as anaphylaxis. The default response to food antigens, which is antigen specific immune tolerance, requires exposure to the antigen and is already initiated during pregnancy. After birth, tolerance is mostly acquired in the gut after oral ingestion of dietary proteins, whilst exposure to these same proteins via the skin, especially when it is inflamed and has a disrupted barrier, can lead to allergic sensitization. The crosstalk between the skin and the gut, which is involved in the induction of food allergy, is still incompletely understood. In this review, we will focus on mechanisms underlying allergic sensitization (to food antigens) via the skin, leading to gastrointestinal inflammation, and the development of IgE-mediated food allergy. Better understanding of these processes will eventually help to develop new preventive and therapeutic strategies in children. |
format |
Article/Letter to editor |
topic_facet |
Atopic dermatitis Cutaneous sensitization Food allergy Microbiota Skin-gut-axis |
author |
van Splunter, M.E. Liu, Liu van Neerven, Joost Wichers, H.J. Hettinga, K.A. De Jong, Nicolette W. |
author_facet |
van Splunter, M.E. Liu, Liu van Neerven, Joost Wichers, H.J. Hettinga, K.A. De Jong, Nicolette W. |
author_sort |
van Splunter, M.E. |
title |
Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy |
title_short |
Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy |
title_full |
Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy |
title_fullStr |
Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy |
title_full_unstemmed |
Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy |
title_sort |
mechanisms underlying the skin-gut cross talk in the development of ige-mediated food allergy |
url |
https://research.wur.nl/en/publications/mechanisms-underlying-the-skin-gut-cross-talk-in-the-development- |
work_keys_str_mv |
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