Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss
Hydrogenosomes are H2-producing mitochondrial homologs found in some anaerobic microbial eukaryotes that provide a rare intracellular niche for H2-utilizing endosymbiotic archaea. Among ciliates, anaerobic and aerobic lineages are interspersed, demonstrating that the switch to an anaerobic lifestyle with hydrogenosomes has occurred repeatedly and independently. To investigate the molecular details of this transition, we generated genomic and transcriptomic data sets from anaerobic ciliates representing three distinct lineages. Our data demonstrate that hydrogenosomes have evolved from ancestral mitochondria in each case and reveal different degrees of independent mitochondrial genome and proteome reductive evolution, including the first example of complete mitochondrial genome loss in ciliates. Intriguingly, the FeFe-hydrogenase used for generating H2 has a unique domain structure among eukaryotes and appears to have been present, potentially through a single lateral gene transfer from an unknown donor, in the common aerobic ancestor of all three lineages. The early acquisition and retention of FeFe-hydrogenase helps to explain the facility whereby mitochondrial function can be so radically modified within this diverse and ecologically important group of microbial eukaryotes.
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Format: | Article/Letter to editor biblioteca |
Language: | English |
Subjects: | anaerobic metabolism, evolution, genomics, hydrogenosomes, microbial eukaryotes, mitochondria, |
Online Access: | https://research.wur.nl/en/publications/convergent-evolution-of-hydrogenosomes-from-mitochondria-by-gene- |
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dig-wur-nl-wurpubs-5614162024-10-02 Lewis, William H. Lind, Anders E. Sendra, Kacper M. Onsbring, Henning Williams, Tom A. Esteban, Genoveva F. Hirt, Robert P. Ettema, Thijs J.G. Embley, T.M. Article/Letter to editor Molecular Biology and Evolution 37 (2020) 2 ISSN: 0737-4038 Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss 2020 Hydrogenosomes are H2-producing mitochondrial homologs found in some anaerobic microbial eukaryotes that provide a rare intracellular niche for H2-utilizing endosymbiotic archaea. Among ciliates, anaerobic and aerobic lineages are interspersed, demonstrating that the switch to an anaerobic lifestyle with hydrogenosomes has occurred repeatedly and independently. To investigate the molecular details of this transition, we generated genomic and transcriptomic data sets from anaerobic ciliates representing three distinct lineages. Our data demonstrate that hydrogenosomes have evolved from ancestral mitochondria in each case and reveal different degrees of independent mitochondrial genome and proteome reductive evolution, including the first example of complete mitochondrial genome loss in ciliates. Intriguingly, the FeFe-hydrogenase used for generating H2 has a unique domain structure among eukaryotes and appears to have been present, potentially through a single lateral gene transfer from an unknown donor, in the common aerobic ancestor of all three lineages. The early acquisition and retention of FeFe-hydrogenase helps to explain the facility whereby mitochondrial function can be so radically modified within this diverse and ecologically important group of microbial eukaryotes. en application/pdf https://research.wur.nl/en/publications/convergent-evolution-of-hydrogenosomes-from-mitochondria-by-gene- 10.1093/molbev/msz239 https://edepot.wur.nl/514938 anaerobic metabolism evolution genomics hydrogenosomes microbial eukaryotes mitochondria https://creativecommons.org/licenses/by/4.0/ Wageningen University & Research |
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anaerobic metabolism evolution genomics hydrogenosomes microbial eukaryotes mitochondria anaerobic metabolism evolution genomics hydrogenosomes microbial eukaryotes mitochondria |
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anaerobic metabolism evolution genomics hydrogenosomes microbial eukaryotes mitochondria anaerobic metabolism evolution genomics hydrogenosomes microbial eukaryotes mitochondria Lewis, William H. Lind, Anders E. Sendra, Kacper M. Onsbring, Henning Williams, Tom A. Esteban, Genoveva F. Hirt, Robert P. Ettema, Thijs J.G. Embley, T.M. Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss |
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Hydrogenosomes are H2-producing mitochondrial homologs found in some anaerobic microbial eukaryotes that provide a rare intracellular niche for H2-utilizing endosymbiotic archaea. Among ciliates, anaerobic and aerobic lineages are interspersed, demonstrating that the switch to an anaerobic lifestyle with hydrogenosomes has occurred repeatedly and independently. To investigate the molecular details of this transition, we generated genomic and transcriptomic data sets from anaerobic ciliates representing three distinct lineages. Our data demonstrate that hydrogenosomes have evolved from ancestral mitochondria in each case and reveal different degrees of independent mitochondrial genome and proteome reductive evolution, including the first example of complete mitochondrial genome loss in ciliates. Intriguingly, the FeFe-hydrogenase used for generating H2 has a unique domain structure among eukaryotes and appears to have been present, potentially through a single lateral gene transfer from an unknown donor, in the common aerobic ancestor of all three lineages. The early acquisition and retention of FeFe-hydrogenase helps to explain the facility whereby mitochondrial function can be so radically modified within this diverse and ecologically important group of microbial eukaryotes. |
format |
Article/Letter to editor |
topic_facet |
anaerobic metabolism evolution genomics hydrogenosomes microbial eukaryotes mitochondria |
author |
Lewis, William H. Lind, Anders E. Sendra, Kacper M. Onsbring, Henning Williams, Tom A. Esteban, Genoveva F. Hirt, Robert P. Ettema, Thijs J.G. Embley, T.M. |
author_facet |
Lewis, William H. Lind, Anders E. Sendra, Kacper M. Onsbring, Henning Williams, Tom A. Esteban, Genoveva F. Hirt, Robert P. Ettema, Thijs J.G. Embley, T.M. |
author_sort |
Lewis, William H. |
title |
Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss |
title_short |
Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss |
title_full |
Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss |
title_fullStr |
Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss |
title_full_unstemmed |
Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss |
title_sort |
convergent evolution of hydrogenosomes from mitochondria by gene transfer and loss |
url |
https://research.wur.nl/en/publications/convergent-evolution-of-hydrogenosomes-from-mitochondria-by-gene- |
work_keys_str_mv |
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