Effects of bovine immunoglobulin on immune function, allergy and infection

This review aims to provide an in depth overview of the current knowledge of the effects of bovine immunoglobulins on the human immune system. The stability and functional effects of orally ingested bovine immunoglobulins in milk products are described and potential mechanisms of action are discussed. Orally ingested bovine IgG (bovine IgG) can be recovered from feces, ranging from very low levels up to 50% of the ingested IgG that has passed through the gastrointestinal tract. In infants the recovered levels are higher than in adults most likely due to differences in stomach and intestinal conditions such as pH. This indicates that bovine IgG can be functionally active throughout the gastrointestinal tract. Indeed, a large number of studies in infants and adults have shown that bovine IgG (or colostrum as a rich source thereof) can prevent gastrointestinal tract infections, upper respiratory tract infections, and LPS-induced inflammation. These studies vary considerably in target group, design, source of bovine IgG, dosage, and endpoints measured making it hard to draw general conclusions on effectiveness of bovine immunoglobulin rich preparations. Typical sources of bovine IgG used in human studies are serum-derived IgG, colostrum, colostrum-derived IgG, or milk-derived immunoglobulins. In addition, many studies have used IgG from vaccinated cows, but studies using IgG from nonimmunized animals have also been reported to be effective. Mechanistically, bovine IgG binds to many human pathogens and allergens, can neutralize experimental infection of human cells, and limits gastrointestinal inflammation. Furthermore, bovine IgG binds to human Fc receptors which, enhances phagocytosis, killing of bacteria and antigen presentation and bovine IgG supports gastrointestinal barrier function in in vitro models. These mechanisms are becoming more and more established and explain why bovine IgG can have immunological effects in vivo. The inclusion of oral bovine immunoglobulins in specialized dairy products and infant nutrition may therefore be a promising approach to support immune function in vulnerable groups such as infants, children, elderly and immunocompromised patients.

Saved in:
Bibliographic Details
Main Authors: Ulfman, L.H., Leusen, J.H.W., Savelkoul, H.F.J., Warner, John O., van Neerven, R.J.J.
Format: Article/Letter to editor biblioteca
Language:English
Subjects:allergy, bovine immunoglobulins, colostrum, immune, infection, milk,
Online Access:https://research.wur.nl/en/publications/effects-of-bovine-immunoglobulin-on-immune-function-allergy-and-i
Tags: Add Tag
No Tags, Be the first to tag this record!
id dig-wur-nl-wurpubs-547195
record_format koha
spelling dig-wur-nl-wurpubs-5471952024-12-04 Ulfman, L.H. Leusen, J.H.W. Savelkoul, H.F.J. Warner, John O. van Neerven, R.J.J. Article/Letter to editor Frontiers in Nutrition 5 (2018) ISSN: 2296-861X Effects of bovine immunoglobulin on immune function, allergy and infection 2018 This review aims to provide an in depth overview of the current knowledge of the effects of bovine immunoglobulins on the human immune system. The stability and functional effects of orally ingested bovine immunoglobulins in milk products are described and potential mechanisms of action are discussed. Orally ingested bovine IgG (bovine IgG) can be recovered from feces, ranging from very low levels up to 50% of the ingested IgG that has passed through the gastrointestinal tract. In infants the recovered levels are higher than in adults most likely due to differences in stomach and intestinal conditions such as pH. This indicates that bovine IgG can be functionally active throughout the gastrointestinal tract. Indeed, a large number of studies in infants and adults have shown that bovine IgG (or colostrum as a rich source thereof) can prevent gastrointestinal tract infections, upper respiratory tract infections, and LPS-induced inflammation. These studies vary considerably in target group, design, source of bovine IgG, dosage, and endpoints measured making it hard to draw general conclusions on effectiveness of bovine immunoglobulin rich preparations. Typical sources of bovine IgG used in human studies are serum-derived IgG, colostrum, colostrum-derived IgG, or milk-derived immunoglobulins. In addition, many studies have used IgG from vaccinated cows, but studies using IgG from nonimmunized animals have also been reported to be effective. Mechanistically, bovine IgG binds to many human pathogens and allergens, can neutralize experimental infection of human cells, and limits gastrointestinal inflammation. Furthermore, bovine IgG binds to human Fc receptors which, enhances phagocytosis, killing of bacteria and antigen presentation and bovine IgG supports gastrointestinal barrier function in in vitro models. These mechanisms are becoming more and more established and explain why bovine IgG can have immunological effects in vivo. The inclusion of oral bovine immunoglobulins in specialized dairy products and infant nutrition may therefore be a promising approach to support immune function in vulnerable groups such as infants, children, elderly and immunocompromised patients. en application/pdf https://research.wur.nl/en/publications/effects-of-bovine-immunoglobulin-on-immune-function-allergy-and-i 10.3389/fnut.2018.00052 https://edepot.wur.nl/469911 allergy bovine immunoglobulins colostrum immune infection milk https://creativecommons.org/licenses/by/4.0/ Wageningen University & Research
institution WUR NL
collection DSpace
country Países bajos
countrycode NL
component Bibliográfico
access En linea
databasecode dig-wur-nl
tag biblioteca
region Europa del Oeste
libraryname WUR Library Netherlands
language English
topic allergy
bovine immunoglobulins
colostrum
immune
infection
milk
allergy
bovine immunoglobulins
colostrum
immune
infection
milk
spellingShingle allergy
bovine immunoglobulins
colostrum
immune
infection
milk
allergy
bovine immunoglobulins
colostrum
immune
infection
milk
Ulfman, L.H.
Leusen, J.H.W.
Savelkoul, H.F.J.
Warner, John O.
van Neerven, R.J.J.
Effects of bovine immunoglobulin on immune function, allergy and infection
description This review aims to provide an in depth overview of the current knowledge of the effects of bovine immunoglobulins on the human immune system. The stability and functional effects of orally ingested bovine immunoglobulins in milk products are described and potential mechanisms of action are discussed. Orally ingested bovine IgG (bovine IgG) can be recovered from feces, ranging from very low levels up to 50% of the ingested IgG that has passed through the gastrointestinal tract. In infants the recovered levels are higher than in adults most likely due to differences in stomach and intestinal conditions such as pH. This indicates that bovine IgG can be functionally active throughout the gastrointestinal tract. Indeed, a large number of studies in infants and adults have shown that bovine IgG (or colostrum as a rich source thereof) can prevent gastrointestinal tract infections, upper respiratory tract infections, and LPS-induced inflammation. These studies vary considerably in target group, design, source of bovine IgG, dosage, and endpoints measured making it hard to draw general conclusions on effectiveness of bovine immunoglobulin rich preparations. Typical sources of bovine IgG used in human studies are serum-derived IgG, colostrum, colostrum-derived IgG, or milk-derived immunoglobulins. In addition, many studies have used IgG from vaccinated cows, but studies using IgG from nonimmunized animals have also been reported to be effective. Mechanistically, bovine IgG binds to many human pathogens and allergens, can neutralize experimental infection of human cells, and limits gastrointestinal inflammation. Furthermore, bovine IgG binds to human Fc receptors which, enhances phagocytosis, killing of bacteria and antigen presentation and bovine IgG supports gastrointestinal barrier function in in vitro models. These mechanisms are becoming more and more established and explain why bovine IgG can have immunological effects in vivo. The inclusion of oral bovine immunoglobulins in specialized dairy products and infant nutrition may therefore be a promising approach to support immune function in vulnerable groups such as infants, children, elderly and immunocompromised patients.
format Article/Letter to editor
topic_facet allergy
bovine immunoglobulins
colostrum
immune
infection
milk
author Ulfman, L.H.
Leusen, J.H.W.
Savelkoul, H.F.J.
Warner, John O.
van Neerven, R.J.J.
author_facet Ulfman, L.H.
Leusen, J.H.W.
Savelkoul, H.F.J.
Warner, John O.
van Neerven, R.J.J.
author_sort Ulfman, L.H.
title Effects of bovine immunoglobulin on immune function, allergy and infection
title_short Effects of bovine immunoglobulin on immune function, allergy and infection
title_full Effects of bovine immunoglobulin on immune function, allergy and infection
title_fullStr Effects of bovine immunoglobulin on immune function, allergy and infection
title_full_unstemmed Effects of bovine immunoglobulin on immune function, allergy and infection
title_sort effects of bovine immunoglobulin on immune function, allergy and infection
url https://research.wur.nl/en/publications/effects-of-bovine-immunoglobulin-on-immune-function-allergy-and-i
work_keys_str_mv AT ulfmanlh effectsofbovineimmunoglobulinonimmunefunctionallergyandinfection
AT leusenjhw effectsofbovineimmunoglobulinonimmunefunctionallergyandinfection
AT savelkoulhfj effectsofbovineimmunoglobulinonimmunefunctionallergyandinfection
AT warnerjohno effectsofbovineimmunoglobulinonimmunefunctionallergyandinfection
AT vanneervenrjj effectsofbovineimmunoglobulinonimmunefunctionallergyandinfection
_version_ 1819146756755030016