The effects of the multispecies probiotic mixture Ecologic®Barrier on migraine: results of an open-label pilot study
Migraine prevalence is associated with gastrointestinal disorders. Possible underlying mechanisms could be increased gut permeability and inflammation. Probiotics may decrease intestinal permeability as well as inflammation, and therefore may reduce the frequency and/or intensity of migraine attacks. Therefore we assessed feasibility, possible clinical efficacy, and adverse reactions of probiotic treatment in migraine patients. 29 migraine patients took 2 g/d of a probiotic food supplement (Ecologic®Barrier, 2.5×109 cfu/g) during 12 weeks. Participants recorded frequency and intensity of migraine in a headache diary and completed the Migraine Disability Assessment Scale (MIDAS) and Henry Ford Hospital Headache Disability Inventory (HDI) at baseline and after 12 weeks of treatment. Compliance was measured every 4 weeks by counting the remaining sachets with probiotics. The study was completed by 27/29 (93%) patients who took 95% of the supplements. Obstipation was reported by 4 patients during the first 2 weeks of treatment only. The mean±standard deviation (SD) number of migraine days/month decreased significantly from 6.7±2.4 at baseline to 5.1±2.2 (P=0.008) in week 5-8 and 5.2±2.4 in week 9-12 (P=0.001). The mean±SD intensity of migraine decreased significantly from 6.3±1.5 at baseline to 5.5±1.9 after treatment (P=0.005). The MIDAS score improved from 24.8±25.5 to 16.6±13.5 (P=0.031). However, the mean HDI did not change significantly. In conclusion, probiotics may decrease migraine supporting a possible role for the intestine in migraine management. Feasibility and lack of adverse reactions justify further placebo-controlled studies.
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| Format: | Article/Letter to editor biblioteca |
| Language: | English |
| Subjects: | Feasibility, Gut permeability, Headache, Intestine, Leaky gut, Migraine, Probiotics, |
| Online Access: | https://research.wur.nl/en/publications/the-effects-of-the-multispecies-probiotic-mixture-ecologicbarrier |
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dig-wur-nl-wurpubs-4881542025-01-20 de Roos, N.M. Giezenaar, C.G.T. Rovers, J.M.P. Witteman, B.J.M. Smits, M. van Hemert, S. Article/Letter to editor Beneficial Microbes 6 (2015) 5 ISSN: 1876-2883 The effects of the multispecies probiotic mixture Ecologic®Barrier on migraine: results of an open-label pilot study 2015 Migraine prevalence is associated with gastrointestinal disorders. Possible underlying mechanisms could be increased gut permeability and inflammation. Probiotics may decrease intestinal permeability as well as inflammation, and therefore may reduce the frequency and/or intensity of migraine attacks. Therefore we assessed feasibility, possible clinical efficacy, and adverse reactions of probiotic treatment in migraine patients. 29 migraine patients took 2 g/d of a probiotic food supplement (Ecologic®Barrier, 2.5×109 cfu/g) during 12 weeks. Participants recorded frequency and intensity of migraine in a headache diary and completed the Migraine Disability Assessment Scale (MIDAS) and Henry Ford Hospital Headache Disability Inventory (HDI) at baseline and after 12 weeks of treatment. Compliance was measured every 4 weeks by counting the remaining sachets with probiotics. The study was completed by 27/29 (93%) patients who took 95% of the supplements. Obstipation was reported by 4 patients during the first 2 weeks of treatment only. The mean±standard deviation (SD) number of migraine days/month decreased significantly from 6.7±2.4 at baseline to 5.1±2.2 (P=0.008) in week 5-8 and 5.2±2.4 in week 9-12 (P=0.001). The mean±SD intensity of migraine decreased significantly from 6.3±1.5 at baseline to 5.5±1.9 after treatment (P=0.005). The MIDAS score improved from 24.8±25.5 to 16.6±13.5 (P=0.031). However, the mean HDI did not change significantly. In conclusion, probiotics may decrease migraine supporting a possible role for the intestine in migraine management. Feasibility and lack of adverse reactions justify further placebo-controlled studies. en application/pdf https://research.wur.nl/en/publications/the-effects-of-the-multispecies-probiotic-mixture-ecologicbarrier 10.3920/BM2015.0003 https://edepot.wur.nl/342675 Feasibility Gut permeability Headache Intestine Leaky gut Migraine Probiotics Wageningen University & Research |
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Feasibility Gut permeability Headache Intestine Leaky gut Migraine Probiotics Feasibility Gut permeability Headache Intestine Leaky gut Migraine Probiotics |
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Feasibility Gut permeability Headache Intestine Leaky gut Migraine Probiotics Feasibility Gut permeability Headache Intestine Leaky gut Migraine Probiotics de Roos, N.M. Giezenaar, C.G.T. Rovers, J.M.P. Witteman, B.J.M. Smits, M. van Hemert, S. The effects of the multispecies probiotic mixture Ecologic®Barrier on migraine: results of an open-label pilot study |
| description |
Migraine prevalence is associated with gastrointestinal disorders. Possible underlying mechanisms could be increased gut permeability and inflammation. Probiotics may decrease intestinal permeability as well as inflammation, and therefore may reduce the frequency and/or intensity of migraine attacks. Therefore we assessed feasibility, possible clinical efficacy, and adverse reactions of probiotic treatment in migraine patients. 29 migraine patients took 2 g/d of a probiotic food supplement (Ecologic®Barrier, 2.5×109 cfu/g) during 12 weeks. Participants recorded frequency and intensity of migraine in a headache diary and completed the Migraine Disability Assessment Scale (MIDAS) and Henry Ford Hospital Headache Disability Inventory (HDI) at baseline and after 12 weeks of treatment. Compliance was measured every 4 weeks by counting the remaining sachets with probiotics. The study was completed by 27/29 (93%) patients who took 95% of the supplements. Obstipation was reported by 4 patients during the first 2 weeks of treatment only. The mean±standard deviation (SD) number of migraine days/month decreased significantly from 6.7±2.4 at baseline to 5.1±2.2 (P=0.008) in week 5-8 and 5.2±2.4 in week 9-12 (P=0.001). The mean±SD intensity of migraine decreased significantly from 6.3±1.5 at baseline to 5.5±1.9 after treatment (P=0.005). The MIDAS score improved from 24.8±25.5 to 16.6±13.5 (P=0.031). However, the mean HDI did not change significantly. In conclusion, probiotics may decrease migraine supporting a possible role for the intestine in migraine management. Feasibility and lack of adverse reactions justify further placebo-controlled studies. |
| format |
Article/Letter to editor |
| topic_facet |
Feasibility Gut permeability Headache Intestine Leaky gut Migraine Probiotics |
| author |
de Roos, N.M. Giezenaar, C.G.T. Rovers, J.M.P. Witteman, B.J.M. Smits, M. van Hemert, S. |
| author_facet |
de Roos, N.M. Giezenaar, C.G.T. Rovers, J.M.P. Witteman, B.J.M. Smits, M. van Hemert, S. |
| author_sort |
de Roos, N.M. |
| title |
The effects of the multispecies probiotic mixture Ecologic®Barrier on migraine: results of an open-label pilot study |
| title_short |
The effects of the multispecies probiotic mixture Ecologic®Barrier on migraine: results of an open-label pilot study |
| title_full |
The effects of the multispecies probiotic mixture Ecologic®Barrier on migraine: results of an open-label pilot study |
| title_fullStr |
The effects of the multispecies probiotic mixture Ecologic®Barrier on migraine: results of an open-label pilot study |
| title_full_unstemmed |
The effects of the multispecies probiotic mixture Ecologic®Barrier on migraine: results of an open-label pilot study |
| title_sort |
effects of the multispecies probiotic mixture ecologic®barrier on migraine: results of an open-label pilot study |
| url |
https://research.wur.nl/en/publications/the-effects-of-the-multispecies-probiotic-mixture-ecologicbarrier |
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