antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
Bacterial and fungal secondary metabolism is a rich source of novel bioactive compounds with potential pharmaceutical applications as antibiotics, anti-tumor drugs or cholesterol-lowering drugs. To find new drug candidates, microbiologists are increasingly relying on sequencing genomes of a wide variety of microbes. However, rapidly and reliably pinpointing all the potential gene clusters for secondary metabolites in dozens of newly sequenced genomes has been extremely challenging, due to their biochemical heterogeneity, the presence of unknown enzymes and the dispersed nature of the necessary specialized bioinformatics tools and resources. Here, we present antiSMASH (antibiotics & Secondary Metabolite Analysis Shell), the first comprehensive pipeline capable of identifying biosynthetic loci covering the whole range of known secondary metabolite compound classes (polyketides, non-ribosomal peptides, terpenes, aminoglycosides, aminocoumarins, indolocarbazoles, lantibiotics, bacteriocins, nucleosides, beta-lactams, butyrolactones, siderophores, melanins and others). It aligns the identified regions at the gene cluster level to their nearest relatives from a database containing all other known gene clusters, and integrates or cross-links all previously available secondary-metabolite specific gene analysis methods in one interactive view. antiSMASH is available at http://antismash.secondarymetabolites.org.
Main Authors: | Medema, M.H., Blin, K., Cimermancic, P., de Jager, V.C.L., Zakrzewski, P., Fischbach, M.A., Weber, T., Takano, E., Breitling, R. |
---|---|
Format: | Article/Letter to editor biblioteca |
Language: | English |
Subjects: | domains, evolution, natural-products, polyketide synthases, prediction, specificity, |
Online Access: | https://research.wur.nl/en/publications/antismash-rapid-identification-annotation-and-analysis-of-seconda |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Comparative genomics to explore phylogenetic relationship, cryptic sexual potential and host specificity of Rhynchosporium species on grasses
by: Penselin, Daniel, et al. -
Relocation of genes generates non-conserved chromosomal segments in Fusarium graminearum that show distinct and co-regulated gene expression patterns
by: Zhao, C., et al. -
Genomic mutational analysis of the impact of the classical strain improvement program on ß–lactam producing Penicillium chrysogenum
by: Salo, O.V., et al. -
RAIChU : automating the visualisation of natural product biosynthesis
by: Terlouw, Barbara R., et al. -
Emerging roles for diguanylate cyclase during the evolution of soma in dictyostelia
by: Kawabe, Yoshinori, et al.
Published: (2023-10-06)