At the frontier; RXLR effectors crossing the Phytophthora -host interface
Plants are constantly beset by pathogenic organisms. To successfully infect their hosts, plant pathogens secrete effector proteins, many of which are translocated to the inside of the host cell where they manipulate normal physiological processes and undermine host defense. The way by which effectors cross the frontier to reach the inside of the host cell varies among different classes of pathogens. For oomycete plant pathogens – like the potato late blight pathogen Phytophthora infestans – it has been shown that effector translocation to the host cell cytoplasm is dependent on conserved amino acid motifs that are present in the N-terminal part of effector proteins. One of these motifs, known as the RXLR motif, has a strong resemblance with a host translocation motif found in effectors secreted by Plasmodium species. These malaria parasites, that reside inside specialized vacuoles in red blood cells, make use of a specific protein translocation complex to export effectors from the vacuole into the red blood cell. Whether or not also oomycete RXLR effectors require a translocation complex to cross the frontier is still under investigation. For one P. infestans RXLR effector named IPI-O we have found a potential host target that could play a role in establishing the first contact between this effector and the host cell. This membrane spanning lectin receptor kinase, LecRK-I.9, interacts with IPI-O via the tripeptide RGD that overlaps with the RXLR motif. In animals, RGD is a well-known cell adhesion motif; it binds to integrins, which are membrane receptors that regulate many cellular processes and which can be hijacked by pathogens for either effector translocation or pathogen entry into host cells.
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Format: | Article/Letter to editor biblioteca |
Language: | English |
Subjects: | Effector, LecRK-i.9, Lectin receptor kinase, Oomycetes, Phytophthora, RGD, RXLR-dEER, |
Online Access: | https://research.wur.nl/en/publications/at-the-frontier-rxlr-effectors-crossing-the-phytophthora-host-int |
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dig-wur-nl-wurpubs-4136232024-09-23 Bouwmeester, K. Meijer, H.J.G. Govers, F. Article/Letter to editor Frontiers in Plant Science 2 (2011) ISSN: 1664-462X At the frontier; RXLR effectors crossing the Phytophthora -host interface 2011 Plants are constantly beset by pathogenic organisms. To successfully infect their hosts, plant pathogens secrete effector proteins, many of which are translocated to the inside of the host cell where they manipulate normal physiological processes and undermine host defense. The way by which effectors cross the frontier to reach the inside of the host cell varies among different classes of pathogens. For oomycete plant pathogens – like the potato late blight pathogen Phytophthora infestans – it has been shown that effector translocation to the host cell cytoplasm is dependent on conserved amino acid motifs that are present in the N-terminal part of effector proteins. One of these motifs, known as the RXLR motif, has a strong resemblance with a host translocation motif found in effectors secreted by Plasmodium species. These malaria parasites, that reside inside specialized vacuoles in red blood cells, make use of a specific protein translocation complex to export effectors from the vacuole into the red blood cell. Whether or not also oomycete RXLR effectors require a translocation complex to cross the frontier is still under investigation. For one P. infestans RXLR effector named IPI-O we have found a potential host target that could play a role in establishing the first contact between this effector and the host cell. This membrane spanning lectin receptor kinase, LecRK-I.9, interacts with IPI-O via the tripeptide RGD that overlaps with the RXLR motif. In animals, RGD is a well-known cell adhesion motif; it binds to integrins, which are membrane receptors that regulate many cellular processes and which can be hijacked by pathogens for either effector translocation or pathogen entry into host cells. en application/pdf https://research.wur.nl/en/publications/at-the-frontier-rxlr-effectors-crossing-the-phytophthora-host-int 10.3389/fpls.2011.00075 https://edepot.wur.nl/187445 Effector LecRK-i.9 Lectin receptor kinase Oomycetes Phytophthora RGD RXLR-dEER Wageningen University & Research |
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Effector LecRK-i.9 Lectin receptor kinase Oomycetes Phytophthora RGD RXLR-dEER Effector LecRK-i.9 Lectin receptor kinase Oomycetes Phytophthora RGD RXLR-dEER |
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Effector LecRK-i.9 Lectin receptor kinase Oomycetes Phytophthora RGD RXLR-dEER Effector LecRK-i.9 Lectin receptor kinase Oomycetes Phytophthora RGD RXLR-dEER Bouwmeester, K. Meijer, H.J.G. Govers, F. At the frontier; RXLR effectors crossing the Phytophthora -host interface |
description |
Plants are constantly beset by pathogenic organisms. To successfully infect their hosts, plant pathogens secrete effector proteins, many of which are translocated to the inside of the host cell where they manipulate normal physiological processes and undermine host defense. The way by which effectors cross the frontier to reach the inside of the host cell varies among different classes of pathogens. For oomycete plant pathogens – like the potato late blight pathogen Phytophthora infestans – it has been shown that effector translocation to the host cell cytoplasm is dependent on conserved amino acid motifs that are present in the N-terminal part of effector proteins. One of these motifs, known as the RXLR motif, has a strong resemblance with a host translocation motif found in effectors secreted by Plasmodium species. These malaria parasites, that reside inside specialized vacuoles in red blood cells, make use of a specific protein translocation complex to export effectors from the vacuole into the red blood cell. Whether or not also oomycete RXLR effectors require a translocation complex to cross the frontier is still under investigation. For one P. infestans RXLR effector named IPI-O we have found a potential host target that could play a role in establishing the first contact between this effector and the host cell. This membrane spanning lectin receptor kinase, LecRK-I.9, interacts with IPI-O via the tripeptide RGD that overlaps with the RXLR motif. In animals, RGD is a well-known cell adhesion motif; it binds to integrins, which are membrane receptors that regulate many cellular processes and which can be hijacked by pathogens for either effector translocation or pathogen entry into host cells. |
format |
Article/Letter to editor |
topic_facet |
Effector LecRK-i.9 Lectin receptor kinase Oomycetes Phytophthora RGD RXLR-dEER |
author |
Bouwmeester, K. Meijer, H.J.G. Govers, F. |
author_facet |
Bouwmeester, K. Meijer, H.J.G. Govers, F. |
author_sort |
Bouwmeester, K. |
title |
At the frontier; RXLR effectors crossing the Phytophthora -host interface |
title_short |
At the frontier; RXLR effectors crossing the Phytophthora -host interface |
title_full |
At the frontier; RXLR effectors crossing the Phytophthora -host interface |
title_fullStr |
At the frontier; RXLR effectors crossing the Phytophthora -host interface |
title_full_unstemmed |
At the frontier; RXLR effectors crossing the Phytophthora -host interface |
title_sort |
at the frontier; rxlr effectors crossing the phytophthora -host interface |
url |
https://research.wur.nl/en/publications/at-the-frontier-rxlr-effectors-crossing-the-phytophthora-host-int |
work_keys_str_mv |
AT bouwmeesterk atthefrontierrxlreffectorscrossingthephytophthorahostinterface AT meijerhjg atthefrontierrxlreffectorscrossingthephytophthorahostinterface AT goversf atthefrontierrxlreffectorscrossingthephytophthorahostinterface |
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1813203147880923136 |