The decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in the excreta
We carried out energy balance studies in four groups of young, growing, 5-wk-old Balb-C mice (n = 12/group) that were either food restricted or nonrestricted and fed high fat diets (38 energy%) with or without 0.93 g/100 g conjugated linoleic acid (CLA) for 39 d. The energy in carcasses, excreta and food was measured in a bomb calorimeter. CLA lowered the percentage of the energy intake that was stored in the body from 1.9 ± 0.8 to -2.3 ± 0.7% (mean ± SD, P < 0.05) in the nonrestricted mice and from 1.4 ± 1.3 to -2.9 ± 0.7% (P < 0.05) in the restricted mice. Thus, the CLA-treated mice had a net loss of body energy. The percentage of the energy intake eliminated in the excreta increased from 7.6 ± 0.9% in controls to 8.7 ± 1.0% (P < 0.05) in the CLA-treated mice that were nonrestricted and from 7.3 ± 0.8 to 8.4 ± 0.6 (P < 0.05) in the restricted mice. The amount of energy ingested minus the amount retained in carcasses and excreta equals the energy expenditure. The percentage of the energy intake that was expended as heat increased from 90.5 ± 1.2 in controls to 93.6 ± 1.5% (P < 0.05) in the CLA-treated nonrestricted mice and from 91.3 ± 1.5 to 94.5 ± 1.0% (P < 0.05) in the restricted mice. The lower energy storage in the CLA-fed mice was accounted for by an increase in the energy expenditure (74%) and by an increase in energy lost in the excreta (26%). Feeding CLA also increased liver weight, which may warrant further studies on the safety of CLA. -------------------------------------------------------------------------------- KEY WORDS: … mice … conjugated linoleic acid (CLA) … energy balance … energy expenditure
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| Subjects: | Conjugated linoleic acid (CLA), Energy balance, Energy expenditure, Mice, |
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dig-wur-nl-wurpubs-1234532024-09-30 Terpstra, A.H.M. Beynen, A.C. Everts, H. Kocsis, S. Katan, M.B. Zock, P.L. Article/Letter to editor The Journal of Nutrition 132 (2002) 5 ISSN: 0022-3166 The decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in the excreta 2002 We carried out energy balance studies in four groups of young, growing, 5-wk-old Balb-C mice (n = 12/group) that were either food restricted or nonrestricted and fed high fat diets (38 energy%) with or without 0.93 g/100 g conjugated linoleic acid (CLA) for 39 d. The energy in carcasses, excreta and food was measured in a bomb calorimeter. CLA lowered the percentage of the energy intake that was stored in the body from 1.9 ± 0.8 to -2.3 ± 0.7% (mean ± SD, P < 0.05) in the nonrestricted mice and from 1.4 ± 1.3 to -2.9 ± 0.7% (P < 0.05) in the restricted mice. Thus, the CLA-treated mice had a net loss of body energy. The percentage of the energy intake eliminated in the excreta increased from 7.6 ± 0.9% in controls to 8.7 ± 1.0% (P < 0.05) in the CLA-treated mice that were nonrestricted and from 7.3 ± 0.8 to 8.4 ± 0.6 (P < 0.05) in the restricted mice. The amount of energy ingested minus the amount retained in carcasses and excreta equals the energy expenditure. The percentage of the energy intake that was expended as heat increased from 90.5 ± 1.2 in controls to 93.6 ± 1.5% (P < 0.05) in the CLA-treated nonrestricted mice and from 91.3 ± 1.5 to 94.5 ± 1.0% (P < 0.05) in the restricted mice. The lower energy storage in the CLA-fed mice was accounted for by an increase in the energy expenditure (74%) and by an increase in energy lost in the excreta (26%). Feeding CLA also increased liver weight, which may warrant further studies on the safety of CLA. -------------------------------------------------------------------------------- KEY WORDS: … mice … conjugated linoleic acid (CLA) … energy balance … energy expenditure en application/pdf https://research.wur.nl/en/publications/the-decrease-in-body-fat-in-mice-fed-conjugated-linoleic-acid-is- 10.1093/jn/132.5.940 https://edepot.wur.nl/39331 Conjugated linoleic acid (CLA) Energy balance Energy expenditure Mice Wageningen University & Research |
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Conjugated linoleic acid (CLA) Energy balance Energy expenditure Mice Conjugated linoleic acid (CLA) Energy balance Energy expenditure Mice |
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Conjugated linoleic acid (CLA) Energy balance Energy expenditure Mice Conjugated linoleic acid (CLA) Energy balance Energy expenditure Mice Terpstra, A.H.M. Beynen, A.C. Everts, H. Kocsis, S. Katan, M.B. Zock, P.L. The decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in the excreta |
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We carried out energy balance studies in four groups of young, growing, 5-wk-old Balb-C mice (n = 12/group) that were either food restricted or nonrestricted and fed high fat diets (38 energy%) with or without 0.93 g/100 g conjugated linoleic acid (CLA) for 39 d. The energy in carcasses, excreta and food was measured in a bomb calorimeter. CLA lowered the percentage of the energy intake that was stored in the body from 1.9 ± 0.8 to -2.3 ± 0.7% (mean ± SD, P < 0.05) in the nonrestricted mice and from 1.4 ± 1.3 to -2.9 ± 0.7% (P < 0.05) in the restricted mice. Thus, the CLA-treated mice had a net loss of body energy. The percentage of the energy intake eliminated in the excreta increased from 7.6 ± 0.9% in controls to 8.7 ± 1.0% (P < 0.05) in the CLA-treated mice that were nonrestricted and from 7.3 ± 0.8 to 8.4 ± 0.6 (P < 0.05) in the restricted mice. The amount of energy ingested minus the amount retained in carcasses and excreta equals the energy expenditure. The percentage of the energy intake that was expended as heat increased from 90.5 ± 1.2 in controls to 93.6 ± 1.5% (P < 0.05) in the CLA-treated nonrestricted mice and from 91.3 ± 1.5 to 94.5 ± 1.0% (P < 0.05) in the restricted mice. The lower energy storage in the CLA-fed mice was accounted for by an increase in the energy expenditure (74%) and by an increase in energy lost in the excreta (26%). Feeding CLA also increased liver weight, which may warrant further studies on the safety of CLA. -------------------------------------------------------------------------------- KEY WORDS: … mice … conjugated linoleic acid (CLA) … energy balance … energy expenditure |
| format |
Article/Letter to editor |
| topic_facet |
Conjugated linoleic acid (CLA) Energy balance Energy expenditure Mice |
| author |
Terpstra, A.H.M. Beynen, A.C. Everts, H. Kocsis, S. Katan, M.B. Zock, P.L. |
| author_facet |
Terpstra, A.H.M. Beynen, A.C. Everts, H. Kocsis, S. Katan, M.B. Zock, P.L. |
| author_sort |
Terpstra, A.H.M. |
| title |
The decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in the excreta |
| title_short |
The decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in the excreta |
| title_full |
The decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in the excreta |
| title_fullStr |
The decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in the excreta |
| title_full_unstemmed |
The decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in the excreta |
| title_sort |
decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in the excreta |
| url |
https://research.wur.nl/en/publications/the-decrease-in-body-fat-in-mice-fed-conjugated-linoleic-acid-is- |
| work_keys_str_mv |
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