Differential effects of tianeptine on dorsal hippocampal volume in rats subjected to early stress and variable chronic stress during adulthood (#382)
Neonatal maternal separation induces long-term alterations in the hypothalamicpituitary-adrenal axis and may increase vulnerability to depression when a stressful situation occurs in adulthood. Some studies, have found significant reductions in hippocampal volumes in patients with major depression. In contrast to other tricyclic antidepressants, tianeptine, a drug that increases serotonin reuptake, produces fewer side effects.
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| Main Authors: | , , , , |
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| Format: | Fil: Fil: Pollano, Antonella. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. biblioteca |
| Language: | eng |
| Published: |
2014
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| Subjects: | Neonatal maternal separation, Tianeptine, Hippocampus, Depression, |
| Online Access: | http://hdl.handle.net/11086/547720 |
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| Summary: | Neonatal maternal separation induces long-term alterations in the hypothalamicpituitary-adrenal axis and may increase vulnerability to depression when a stressful
situation occurs in adulthood. Some studies, have found significant reductions in
hippocampal volumes in patients with major depression. In contrast to other
tricyclic antidepressants, tianeptine, a drug that increases serotonin reuptake,
produces fewer side effects. |
|---|