Inhibitory effect of n3 polyunsaturated fatty acids on cancer cell growth by p53 activation

Inhibitory effect of n3 polyunsaturated fatty acids on cancer cell growth by p53 activation

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Bibliographic Details
Main Authors: Garay, María Isabel, Comba, Andrea, Vara Mesler, Marianela, Silva, Renata Alejandra, Quiroga, Patricia, Pasqualini, María Eugenia
Format: conferenceObject biblioteca
Language:eng
Published: Argentine Society for biochemistry and molecular biology research 2013
Subjects:N3 polyunsaturated acids, p53, Cáncer,
Online Access:http://hdl.handle.net/11086/22336
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spelling dig-unc-ar-11086-223362022-02-15T20:42:39Z Inhibitory effect of n3 polyunsaturated fatty acids on cancer cell growth by p53 activation Garay, María Isabel Comba, Andrea Vara Mesler, Marianela Silva, Renata Alejandra Quiroga, Patricia Pasqualini, María Eugenia N3 polyunsaturated acids p53 Cáncer 2p Different evidences show the regulatory effect of n-3 and n-6 polyunsaturated fatty acids (PUFAs) on carcinogenesis, however how PUFAS modulate tumor development remains unknown. In this report, we analyzed the in vitro and in vivo effects of n-3 and n-6 PUFAs on a syngeneic murine mammary adenocarcinoma cell line (LMM3). Tumor cells viability was measured by Resazurin and apoptosis by Hoechst. The PUFAs tumor cell membrane profile was analyzed by Gas Chromatography and PUFAs derivatives (eicosanoids) by HPLC. Our results showed that alpha linolenic acid (ALA, C 18:3 n-3) induced significantly higher pro-apoptotic effects than linoleic acid (LA, C18: 2, n-6). Moreover, ex-vivo studies showed that tumor cells from mice fed with ALA enriched diet diminished tumorigenesis by decreasing the tumor cell release of 12 (S)-HETE, a pro-carcinogenic eicosanoid and producing higher levels of pro-apoptotic 12(S)-HHT. In addition, the ALA enriched diet resulted on a higher tumor tissue expression of the pro-apoptotic tp53 tumor suppressor factor. These results provide evidence of the biological pro-apoptotic effects of n-3 PUFAs and particularly, the fatty acid ALA, as the regulator of the signaling pathway tp53. This provided a novel mechanism and a potential target on anticancer treatment. http://www.saib.org.ar/sites/default/files/BIOCELL-SAIB-2013.pdf Fil: Garay, María Isabel. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Biología Celular, Embriología e Histología; Argentina. Fil: Comba, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Fil: Vara Mesler, Marianela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Biología Celular, Embriología e Histología; Argentina. Fil: Silva, Renata Alejandra. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Biología Celular, Embriología e Histología; Argentina. Fil: Quiroga, Patricia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Biología Celular, Embriología e Histología; Argentina. Fil: Pasqualini, María Eugenia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Biología Celular, Embriología e Histología; Argentina. Fil: Pasqualini, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Otras Ciencias Médicas 2022-02-10T21:24:14Z 2022-02-10T21:24:14Z 2013 conferenceObject 0327-9545 http://hdl.handle.net/11086/22336 eng Attribution-NonCommercial-ShareAlike 4.0 International https://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso; Electrónico y/o Digital Argentine Society for biochemistry and molecular biology research
institution UNC AR
collection DSpace
country Argentina
countrycode AR
component Bibliográfico
access En linea
databasecode dig-unc-ar
tag biblioteca
region America del Sur
libraryname Biblioteca 'Ing. Agrónomo Moisés Farber' de la Facultad de Ciencias Agropecuarias
language eng
topic N3 polyunsaturated acids
p53
Cáncer
N3 polyunsaturated acids
p53
Cáncer
spellingShingle N3 polyunsaturated acids
p53
Cáncer
N3 polyunsaturated acids
p53
Cáncer
Garay, María Isabel
Comba, Andrea
Vara Mesler, Marianela
Silva, Renata Alejandra
Quiroga, Patricia
Pasqualini, María Eugenia
Inhibitory effect of n3 polyunsaturated fatty acids on cancer cell growth by p53 activation
description 2p
format conferenceObject
topic_facet N3 polyunsaturated acids
p53
Cáncer
author Garay, María Isabel
Comba, Andrea
Vara Mesler, Marianela
Silva, Renata Alejandra
Quiroga, Patricia
Pasqualini, María Eugenia
author_facet Garay, María Isabel
Comba, Andrea
Vara Mesler, Marianela
Silva, Renata Alejandra
Quiroga, Patricia
Pasqualini, María Eugenia
author_sort Garay, María Isabel
title Inhibitory effect of n3 polyunsaturated fatty acids on cancer cell growth by p53 activation
title_short Inhibitory effect of n3 polyunsaturated fatty acids on cancer cell growth by p53 activation
title_full Inhibitory effect of n3 polyunsaturated fatty acids on cancer cell growth by p53 activation
title_fullStr Inhibitory effect of n3 polyunsaturated fatty acids on cancer cell growth by p53 activation
title_full_unstemmed Inhibitory effect of n3 polyunsaturated fatty acids on cancer cell growth by p53 activation
title_sort inhibitory effect of n3 polyunsaturated fatty acids on cancer cell growth by p53 activation
publisher Argentine Society for biochemistry and molecular biology research
publishDate 2013
url http://hdl.handle.net/11086/22336
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