The interplay between iron accumulation, mitochondrial dysfunction and inflammation during the execution step of neurodegenerative disorders

The interplay between iron accumulation, mitochondrial dysfunction and inflammation during the execution step of neurodegenerative disorders

Artículo de publicación ISI

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Main Authors: Urrutia, Pamela J., Mena, Natalia P., Núñez González, Marco
Format: Artículo de revista biblioteca
Language:English
Published: Frontiers Research Foundation 2014
Subjects:Inflammation, Neurodegeneration, Mitochondrial dysfunction, Iron toxicity, Parkinson's disease,
Online Access:https://repositorio.uchile.cl/handle/2250/133826
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spelling dig-uchile-cl-2250-1338262023-01-25T13:37:48Z The interplay between iron accumulation, mitochondrial dysfunction and inflammation during the execution step of neurodegenerative disorders Urrutia, Pamela J. Mena, Natalia P. Núñez González, Marco Inflammation Neurodegeneration Mitochondrial dysfunction Iron toxicity Parkinson's disease Artículo de publicación ISI A growing set of observations points to mitochondrial dysfunction, iron accumulation, oxidative damage and chronic inflammation as common pathognomonic signs of a number of neurodegenerative diseases that includes Alzheimer's disease, Huntington disease, amyotrophic lateral sclerosis, Friedrich's ataxia and Parkinson's disease. Particularly relevant for neurodegenerative processes is the relationship between mitochondria and iron. The mitochondrion upholds the synthesis of iron sulfur clusters and heme, the most abundant iron-containing prosthetic groups in a large variety of proteins, so a fraction of incoming iron must go through this organelle before reaching its final destination. In turn, the mitochondrial respiratory chain is the source of reactive oxygen species (ROS) derived from leaks in the electron transport chain. The co-existence of both iron and ROS in the secluded space of the mitochondrion makes this organelle particularly prone to hydroxyl radical-mediated damage. In addition, a connection between the loss of iron homeostasis and inflammation is starting to emerge; thus, inflammatory cytokines like TNF-alpha and 1156 induce the synthesis of the divalent metal transporter 1 and promote iron accumulation in neurons and microglia. Here, we review the recent literature on mitochondrial iron homeostasis and the role of inflammation on mitochondria dysfunction and iron accumulation on the neurodegenerative process that lead to cell death in Parkinson's disease. We also put forward the hypothesis that mitochondrial dysfunction, iron accumulation and inflammation are part of a synergistic self-feeding cycle that ends in apoptotic cell death, once the antioxidant cellular defense systems are finally overwhelmed. 2015-09-24T19:44:02Z 2015-09-24T19:44:02Z 2014 Artículo de revista Frontiers in Pharmacology Volumen: 5 Número: 38 Mar 10 2014 doi: 10.3389/fphar.2014.00038 https://repositorio.uchile.cl/handle/2250/133826 en Atribución-NoComercial-SinDerivadas 3.0 Chile http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ application/pdf Frontiers Research Foundation
institution UCHILE CL
collection DSpace
country Chile
countrycode CL
component Bibliográfico
access En linea
databasecode dig-uchile-cl
tag biblioteca
region America del Sur
libraryname Dirección de Servicios de Información y Bibliotecas de la UCHILE
language English
topic Inflammation
Neurodegeneration
Mitochondrial dysfunction
Iron toxicity
Parkinson's disease
Inflammation
Neurodegeneration
Mitochondrial dysfunction
Iron toxicity
Parkinson's disease
spellingShingle Inflammation
Neurodegeneration
Mitochondrial dysfunction
Iron toxicity
Parkinson's disease
Inflammation
Neurodegeneration
Mitochondrial dysfunction
Iron toxicity
Parkinson's disease
Urrutia, Pamela J.
Mena, Natalia P.
Núñez González, Marco
The interplay between iron accumulation, mitochondrial dysfunction and inflammation during the execution step of neurodegenerative disorders
description Artículo de publicación ISI
format Artículo de revista
topic_facet Inflammation
Neurodegeneration
Mitochondrial dysfunction
Iron toxicity
Parkinson's disease
author Urrutia, Pamela J.
Mena, Natalia P.
Núñez González, Marco
author_facet Urrutia, Pamela J.
Mena, Natalia P.
Núñez González, Marco
author_sort Urrutia, Pamela J.
title The interplay between iron accumulation, mitochondrial dysfunction and inflammation during the execution step of neurodegenerative disorders
title_short The interplay between iron accumulation, mitochondrial dysfunction and inflammation during the execution step of neurodegenerative disorders
title_full The interplay between iron accumulation, mitochondrial dysfunction and inflammation during the execution step of neurodegenerative disorders
title_fullStr The interplay between iron accumulation, mitochondrial dysfunction and inflammation during the execution step of neurodegenerative disorders
title_full_unstemmed The interplay between iron accumulation, mitochondrial dysfunction and inflammation during the execution step of neurodegenerative disorders
title_sort interplay between iron accumulation, mitochondrial dysfunction and inflammation during the execution step of neurodegenerative disorders
publisher Frontiers Research Foundation
publishDate 2014
url https://repositorio.uchile.cl/handle/2250/133826
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