Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry
9 páginas, 2 figuras, 1 tabla
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| Format: | artículo biblioteca |
| Language: | English |
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Elsevier
2010
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| Subjects: | Antigens, Dirofilaria immitis, Cats, Mass spectrometry, Soluble proteome, antigens, cats, mass spectrometry, |
| Online Access: | http://hdl.handle.net/10261/345111 http://dx.doi.org/10.13039/501100014180 https://api.elsevier.com/content/abstract/scopus_id/77955842447 |
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dig-irnasa-es-10261-3451112024-05-18T20:36:04Z Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry González Miguel, Javier Morchón, Rodrigo Siles Lucas, Mar Oleaga, Ana Simón Martín, Fernando Junta de Castilla y León González Miguel, Javier [0000-0003-4279-4761] Siles Lucas, Mar [0000-0002-1257-2562] Oleaga, Ana [0000-0002-8019-7354] Antigens Dirofilaria immitis Cats Mass spectrometry Soluble proteome antigens cats Dirofilaria immitis mass spectrometry 9 páginas, 2 figuras, 1 tabla The aim of the present work was to identify proteins of Dirofilaria immitis recognized by the immune system of naturally and experimentally infected cats, using two-dimensional electrophoresis and mass spectrometry. Thirty-five immunoreactive proteins of D. immitis were identified. These proteins are involved in metabolism, plasminogen binding, anti-oxidant and detoxificant activity, up-regulation of the Th2 anti-inflammatory response and other processes. The timing evolution of this recognition pattern indicated that at 2 months post-infection a wide recognition of many parasite proteins belonging to many functional groups is still observed, increasing progressively during the course of the infection. The real effect on the vital capacity of D. immitis worms and on the development of pathological events of feline dirofilariosis will be investigated in the future. This research was supported by Agencia de Desarrollo Económico de Castilla y León (grant SA090/A09), Spain. Peer reviewed 2024-02-02T13:02:14Z 2024-02-02T13:02:14Z 2010 artículo http://purl.org/coar/resource_type/c_6501 Molecular and Biochemical Parasitology 174(1): 78-82 (2010) 0166-6851 http://hdl.handle.net/10261/345111 10.1016/j.molbiopara.2010.06.013 http://dx.doi.org/10.13039/501100014180 20603161 2-s2.0-77955842447 https://api.elsevier.com/content/abstract/scopus_id/77955842447 en Molecular and biochemical parasitology Postprint http://dx.doi.org/10.1016/j.molbiopara.2010.06.013 Sí open Elsevier |
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Antigens Dirofilaria immitis Cats Mass spectrometry Soluble proteome antigens cats Dirofilaria immitis mass spectrometry Antigens Dirofilaria immitis Cats Mass spectrometry Soluble proteome antigens cats Dirofilaria immitis mass spectrometry |
| spellingShingle |
Antigens Dirofilaria immitis Cats Mass spectrometry Soluble proteome antigens cats Dirofilaria immitis mass spectrometry Antigens Dirofilaria immitis Cats Mass spectrometry Soluble proteome antigens cats Dirofilaria immitis mass spectrometry González Miguel, Javier Morchón, Rodrigo Siles Lucas, Mar Oleaga, Ana Simón Martín, Fernando Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry |
| description |
9 páginas, 2 figuras, 1 tabla |
| author2 |
Junta de Castilla y León |
| author_facet |
Junta de Castilla y León González Miguel, Javier Morchón, Rodrigo Siles Lucas, Mar Oleaga, Ana Simón Martín, Fernando |
| format |
artículo |
| topic_facet |
Antigens Dirofilaria immitis Cats Mass spectrometry Soluble proteome antigens cats Dirofilaria immitis mass spectrometry |
| author |
González Miguel, Javier Morchón, Rodrigo Siles Lucas, Mar Oleaga, Ana Simón Martín, Fernando |
| author_sort |
González Miguel, Javier |
| title |
Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry |
| title_short |
Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry |
| title_full |
Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry |
| title_fullStr |
Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry |
| title_full_unstemmed |
Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry |
| title_sort |
identification of dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry |
| publisher |
Elsevier |
| publishDate |
2010 |
| url |
http://hdl.handle.net/10261/345111 http://dx.doi.org/10.13039/501100014180 https://api.elsevier.com/content/abstract/scopus_id/77955842447 |
| work_keys_str_mv |
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| _version_ |
1802820159475286016 |