Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future?
10 páginas, 2 tablas. --
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dig-irnasa-es-10261-1241572021-12-27T16:39:34Z Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future? Manzano Román, Raúl Sánchez Ovejero, Carlos Hernández González, Ana Casulli, Adriano Siles Lucas, Mar European Commission 10 páginas, 2 tablas. -- Cystic echinococcosis (CE) is an important helminthic zoonotic disease caused by the Echinococcus granulosus complex. In humans, CE is a chronic disease driven by the growth of echinococcal cysts in different organs. Prognosis of this disease depends onmultiple factors, including location, number, size, and stage of the cysts, making CE a disease of complex management. CE is usually asymptomatic for years and attracts limited attention from funding organizations and health authorities. For this reason, only experts’ recommendations are available but no evidence-based conclusions have been drawn for CE clinical management. One of those pitfalls refers to the lack of evidence to support the use of serological tools for the diagnosis and follow-up of CE patients. In this respect, crude antigens are used to detect specific antibodies in patients, giving rise to false positive results.The advent of molecular techniques allowing the production of recombinant proteins has provided a number of candidate antigens that could overcome the problems associated with the use of crude parasite extracts in the serological assays. In this review, we present the last advances in this field, proposing the use of serology to support cyst stage-specific diagnosis and follow-up. The research that will lead to these results has received funding from the European Community’s Seventh Framework Programmeunder theGrant agreement 602051 (Project HERACLES: Human cystic Echinococcosis ReseArch in CentraL and Eastern Societies; http://www.Heracles-fp7.eu/). Peer reviewed 2015 artículo http://purl.org/coar/resource_type/c_6501 Biomed Research International 2015: 428205 (2015) 2314-6133 http://hdl.handle.net/10261/124157 10.1155/2015/428205 2314-6141 http://dx.doi.org/10.13039/501100000780 26504805 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/FP7/602051 Publisher's version http://dx.doi.org/10.1155/2015/428205 Sí open Hindawi Publishing Corporation |
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10 páginas, 2 tablas. -- |
| author2 |
European Commission |
| author_facet |
European Commission Manzano Román, Raúl Sánchez Ovejero, Carlos Hernández González, Ana Casulli, Adriano Siles Lucas, Mar |
| format |
artículo |
| author |
Manzano Román, Raúl Sánchez Ovejero, Carlos Hernández González, Ana Casulli, Adriano Siles Lucas, Mar |
| spellingShingle |
Manzano Román, Raúl Sánchez Ovejero, Carlos Hernández González, Ana Casulli, Adriano Siles Lucas, Mar Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future? |
| author_sort |
Manzano Román, Raúl |
| title |
Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future? |
| title_short |
Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future? |
| title_full |
Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future? |
| title_fullStr |
Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future? |
| title_full_unstemmed |
Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future? |
| title_sort |
serological diagnosis and follow-up of human cystic echinococcosis: a new hope for the future? |
| publisher |
Hindawi Publishing Corporation |
| url |
http://hdl.handle.net/10261/124157 http://dx.doi.org/10.13039/501100000780 |
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