Histopathological and immunohistochemical study of lambs experimentally infected with Fasciola hepatica and Schistosoma bovis
11 pages, 1 table, 6 figures.-- PMID: 11204131 [PubMed].
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Blackwell Publishing
2000-12
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dig-irnasa-es-10261-106662021-04-13T14:53:26Z Histopathological and immunohistochemical study of lambs experimentally infected with Fasciola hepatica and Schistosoma bovis Ferreras, Mª del Carmen García-Iglesias, M.J. Manga-González, M. Yolanda Pérez-Martínez, C. Mizinska, Y. Ramajo Martín, Vicente González Lanza, Camino Escudero, A. García Marín, Juan Francisco 11 pages, 1 table, 6 figures.-- PMID: 11204131 [PubMed]. The aim of this study was to investigate the cross-resistance between Fasciola hepatica and Schistosoma bovis in lambs assessing parasitologic, gross pathologic, histopathologic and immunohistochemical changes in liver and small intestine. Thirty Castellana breed lambs were divided into five comparable groups and exposed to F. hepatical S. bovis (group F/S), S. bovis/F. hepatica (group S/F), S. bovis (group S) or F. hepatica (group F) and six unexposed lambs were used as non-infected controls (group C). Primary patent infection with F. hepatica induced a lower number of schistosome eggs and a higher number of lymphocytes in intestinal and liver schistosome egg-induced granulomas in group F/S than in the groups S/F and S, liver damage being mainly attributed to F. hepatica. S. bovis infection followed by challenge with F. hepatica particularly increased the severity of the most significant liver alterations (cholangiohepatitis by F. hepatica and mesoendophlebitis by S. bovis) and F. hepatica seemed not to have an influence on established S. bovis infection. In addition, immunohistochemical results suggested that the predominant local immune response in both double-infected groups was different, being mainly a cell-mediated immune response in group F/S and a mucosal response in group S/F. This work was supported by CICYT grant GAN89-0525 and by the Spanish Foreign Office-Academy of Bulgarian Sciences (Project of Scientific Cooperation). Peer reviewed 2009-02-13T13:15:54Z 2009-02-13T13:15:54Z 2000-12 artículo http://purl.org/coar/resource_type/c_6501 Journal of Veterinary Medicine B 47(10): 763-773 (2000) 0931-1793 http://hdl.handle.net/10261/10666 10.1111/j.1439-0450.2000.00410.x en http://dx.doi.org/10.1111/j.1439-0450.2000.00410.x none 94510 bytes application/pdf Blackwell Publishing |
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11 pages, 1 table, 6 figures.-- PMID: 11204131 [PubMed]. |
| format |
artículo |
| author |
Ferreras, Mª del Carmen García-Iglesias, M.J. Manga-González, M. Yolanda Pérez-Martínez, C. Mizinska, Y. Ramajo Martín, Vicente González Lanza, Camino Escudero, A. García Marín, Juan Francisco |
| spellingShingle |
Ferreras, Mª del Carmen García-Iglesias, M.J. Manga-González, M. Yolanda Pérez-Martínez, C. Mizinska, Y. Ramajo Martín, Vicente González Lanza, Camino Escudero, A. García Marín, Juan Francisco Histopathological and immunohistochemical study of lambs experimentally infected with Fasciola hepatica and Schistosoma bovis |
| author_facet |
Ferreras, Mª del Carmen García-Iglesias, M.J. Manga-González, M. Yolanda Pérez-Martínez, C. Mizinska, Y. Ramajo Martín, Vicente González Lanza, Camino Escudero, A. García Marín, Juan Francisco |
| author_sort |
Ferreras, Mª del Carmen |
| title |
Histopathological and immunohistochemical study of lambs experimentally infected with Fasciola hepatica and Schistosoma bovis |
| title_short |
Histopathological and immunohistochemical study of lambs experimentally infected with Fasciola hepatica and Schistosoma bovis |
| title_full |
Histopathological and immunohistochemical study of lambs experimentally infected with Fasciola hepatica and Schistosoma bovis |
| title_fullStr |
Histopathological and immunohistochemical study of lambs experimentally infected with Fasciola hepatica and Schistosoma bovis |
| title_full_unstemmed |
Histopathological and immunohistochemical study of lambs experimentally infected with Fasciola hepatica and Schistosoma bovis |
| title_sort |
histopathological and immunohistochemical study of lambs experimentally infected with fasciola hepatica and schistosoma bovis |
| publisher |
Blackwell Publishing |
| publishDate |
2000-12 |
| url |
http://hdl.handle.net/10261/10666 |
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