Activation of the plasma membrane Na/H antiporter salt-overly-sensitive 1 (SOS1) by phosphorylation of an auto-inhibitory C-terminal domain
Quintero et al.-- 6 páginas, 4 figuras, 25 referencias y 4 páginas adicionales con 5 figuras y 2 tablas.
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National Academy of Sciences (U.S.)
2011-01
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Subjects: | Ion transport, Salinity, Spdium tolerance, |
Online Access: | http://hdl.handle.net/10261/37957 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100000002 http://dx.doi.org/10.13039/501100004085 |
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dig-irnas-es-10261-379572021-12-28T16:38:39Z Activation of the plasma membrane Na/H antiporter salt-overly-sensitive 1 (SOS1) by phosphorylation of an auto-inhibitory C-terminal domain Quintero, Francisco J. Martínez-Atienza, Juliana Villalta, Irene Mendoza, Imelda Pardo, José M. Ministerio de Ciencia e Innovación (España) European Commission National Institutes of Health (US) Ministry of Education, Science and Technology (South Korea) Ion transport Salinity Spdium tolerance Quintero et al.-- 6 páginas, 4 figuras, 25 referencias y 4 páginas adicionales con 5 figuras y 2 tablas. The plasma membrane sodium/proton exchanger Salt-Overly-Sensitive 1 (SOS1) is a critical salt tolerance determinant in plants. The SOS2-SOS3 calcium-dependent protein kinase complex up-regulates SOS1 activity, but the mechanistic details of this crucial event remain unresolved. Here we show that SOS1 is maintained in a resting state by a C-terminal auto-inhibitory domain that is the target of SOS2-SOS3. The auto-inhibitory domain interacts intramolecularly with an adjacent domain of SOS1 that is essential for activity. SOS1 is relieved from auto-inhibition upon phosphorylation of the auto-inhibitory domain by SOS2-SOS3. Mutation of the SOS2 phosphorylation and recognition site impeded the activation of SOS1 in vivo and in vitro. Additional amino acid residues critically important for SOS1 activity and regulation were identified in a genetic screen for hypermorphic alleles. This work was supported by Grants BIO2009-08641 and CSD2007-00057 from the Ministerio de Ciencia e Innovación (cofinanced by Fondo Europeo de Desarrollo Regional) (to J.M.P. and F.J.Q.), World Class University Program Grant R32-10148 (to D.-J.Y. and W.Y.K.), and National Institutes of Health Grants R01GM070795 and R01GM059138 (to J.-K.Z.). Peer reviewed 2011-07-24T19:30:38Z 2011-07-24T19:30:38Z 2011-01 artículo http://purl.org/coar/resource_type/c_6501 Proceedings of the National Academy of Sciences of the USA 108 (6): 2611-2616 (2011) 0027-8424 http://hdl.handle.net/10261/37957 10.1073/pnas.1018921108 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100000002 http://dx.doi.org/10.13039/501100004085 21262798 en http://dx.doi.org/10.1073/pnas.1018921108 open National Academy of Sciences (U.S.) |
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Ion transport Salinity Spdium tolerance Ion transport Salinity Spdium tolerance |
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Ion transport Salinity Spdium tolerance Ion transport Salinity Spdium tolerance Quintero, Francisco J. Martínez-Atienza, Juliana Villalta, Irene Mendoza, Imelda Pardo, José M. Activation of the plasma membrane Na/H antiporter salt-overly-sensitive 1 (SOS1) by phosphorylation of an auto-inhibitory C-terminal domain |
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Quintero et al.-- 6 páginas, 4 figuras, 25 referencias y 4 páginas adicionales con 5 figuras y 2 tablas. |
author2 |
Ministerio de Ciencia e Innovación (España) |
author_facet |
Ministerio de Ciencia e Innovación (España) Quintero, Francisco J. Martínez-Atienza, Juliana Villalta, Irene Mendoza, Imelda Pardo, José M. |
format |
artículo |
topic_facet |
Ion transport Salinity Spdium tolerance |
author |
Quintero, Francisco J. Martínez-Atienza, Juliana Villalta, Irene Mendoza, Imelda Pardo, José M. |
author_sort |
Quintero, Francisco J. |
title |
Activation of the plasma membrane Na/H antiporter salt-overly-sensitive 1 (SOS1) by phosphorylation of an auto-inhibitory C-terminal domain |
title_short |
Activation of the plasma membrane Na/H antiporter salt-overly-sensitive 1 (SOS1) by phosphorylation of an auto-inhibitory C-terminal domain |
title_full |
Activation of the plasma membrane Na/H antiporter salt-overly-sensitive 1 (SOS1) by phosphorylation of an auto-inhibitory C-terminal domain |
title_fullStr |
Activation of the plasma membrane Na/H antiporter salt-overly-sensitive 1 (SOS1) by phosphorylation of an auto-inhibitory C-terminal domain |
title_full_unstemmed |
Activation of the plasma membrane Na/H antiporter salt-overly-sensitive 1 (SOS1) by phosphorylation of an auto-inhibitory C-terminal domain |
title_sort |
activation of the plasma membrane na/h antiporter salt-overly-sensitive 1 (sos1) by phosphorylation of an auto-inhibitory c-terminal domain |
publisher |
National Academy of Sciences (U.S.) |
publishDate |
2011-01 |
url |
http://hdl.handle.net/10261/37957 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100000002 http://dx.doi.org/10.13039/501100004085 |
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