Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor
10 pages, 5 figures, 44 references. Narasimhan, Meena L. et al.--
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Elsevier
2005-01-21
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| Online Access: | http://hdl.handle.net/10261/37772 http://dx.doi.org/10.13039/100000001 http://dx.doi.org/10.13039/501100003711 http://dx.doi.org/10.13039/501100004084 |
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dig-irnas-es-10261-377722020-04-15T08:03:42Z Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor Narasimhan, Meena L. Bressan, Ray A. Coca, María Pardo, José M. National Science Foundation (US) Ministry of Science and Technology (South Korea) Korea Science and Engineering Foundation Organization for Pharmaceutical Safety and Research (Japan) 10 pages, 5 figures, 44 references. Narasimhan, Meena L. et al.-- The antifungal activity of the PR-5 family of plant defense proteins has been suspected to involve specific plasma membrane component(s) of the fungal target. Osmotin is a tobacco PR-5 family protein that induces apoptosis in the yeast Saccharomyces cerevisiae. We show here that the protein encoded by ORE20/PHO36 (YOL002c), a seven transmembrane domain receptor-like polypeptide that regulates lipid and phosphate metabolism, is an osmotin binding plasma membrane protein that is required for full sensitivity to osmotin. PHO36 functions upstream of RAS2 in the osmotin-induced apoptotic pathway. The mammalian homolog of PHO36 is a receptor for the hormone adiponectin and regulates cellular lipid and sugar metabolism. Osmotin and adiponectin, the corresponding “receptor” binding proteins, do not share sequence similarity. However, the β barrel domain of both proteins can be overlapped, and osmotin, like adiponectin, activates AMP kinase in C2C12 myocytes via adiponectin receptors. This work was supported in part by funds from the National Science Foundation Award number 9808551-MCB (to R.A.B.); The Plant Diversity Research Center of the 21st Century Frontier Research Program, Ministry of Science and Technology (grant PF0330401-00 to D.-J.Y.); and an NCRC Project Grant from KOSEF/MOST, Korea (grant R15-2003-002-01002- 0 to D.-J.Y.). This work was also supported by the Program for Promotion of Fundamental Studies in Health Sciences of the Organization for Pharmaceutical Safety and Research of Japan. Peer reviewed 2011-07-14T12:38:39Z 2011-07-14T12:38:39Z 2005-01-21 artículo http://purl.org/coar/resource_type/c_6501 Molecular Cell 17 (2): 171-180 (2005) 1097-2765 http://hdl.handle.net/10261/37772 10.1016/j.molcel.2004.11.050 http://dx.doi.org/10.13039/100000001 http://dx.doi.org/10.13039/501100003711 http://dx.doi.org/10.13039/501100004084 en Postprint http://dx.doi.org/10.1016/j.molcel.2004.11.050 open Elsevier |
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| description |
10 pages, 5 figures, 44 references. Narasimhan, Meena L. et al.-- |
| author2 |
National Science Foundation (US) |
| author_facet |
National Science Foundation (US) Narasimhan, Meena L. Bressan, Ray A. Coca, María Pardo, José M. |
| format |
artículo |
| author |
Narasimhan, Meena L. Bressan, Ray A. Coca, María Pardo, José M. |
| spellingShingle |
Narasimhan, Meena L. Bressan, Ray A. Coca, María Pardo, José M. Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor |
| author_sort |
Narasimhan, Meena L. |
| title |
Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor |
| title_short |
Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor |
| title_full |
Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor |
| title_fullStr |
Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor |
| title_full_unstemmed |
Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor |
| title_sort |
osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor |
| publisher |
Elsevier |
| publishDate |
2005-01-21 |
| url |
http://hdl.handle.net/10261/37772 http://dx.doi.org/10.13039/100000001 http://dx.doi.org/10.13039/501100003711 http://dx.doi.org/10.13039/501100004084 |
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| _version_ |
1777664189711515648 |