Ecological Analyses of Mycobacteria in Showerhead Biofilms and Their Relevance to Human Health
15 páginas.- 5 figuras.- 70 referencias.- Supplemental material for this article may be found at https://doi.org/10.1128/mBio.01614-18
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | artículo biblioteca |
| Language: | English |
| Published: |
American Society for Microbiology
2018-10-30
|
| Subjects: | Mycobacterium, NTM lung disease, Nontuberculous mycobacterial infection, plumbing biofilms, |
| Online Access: | http://hdl.handle.net/10261/336743 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
dig-irnas-es-10261-336743 |
|---|---|
| record_format |
koha |
| spelling |
dig-irnas-es-10261-3367432023-10-06T19:08:27Z Ecological Analyses of Mycobacteria in Showerhead Biofilms and Their Relevance to Human Health Gebert, Matthew J. Delgado-Baquerizo, Manuel Oliverio, Angela M. Webster, Tara M. Nichols, Lauren M. Honda, Jennifer R. Chan, Edward D. Adjemian, Jennifer Dunn, Robert R. Fierer, Noah Cooperative Institute for Research in Environmental Sciences (US) Department of Defense (US) Padosi Foundations European Commission Delgado-Baquerizo, Manuel [0000-0002-6499-576X] Oliverio, Angela M. [0000-0002-0261-039] Fierer, Noah [0000-0002-6432-4261] Mycobacterium NTM lung disease Nontuberculous mycobacterial infection, plumbing biofilms 15 páginas.- 5 figuras.- 70 referencias.- Supplemental material for this article may be found at https://doi.org/10.1128/mBio.01614-18 Bacteria within the genus Mycobacterium can be abundant in showerheads, and the inhalation of aerosolized mycobacteria while showering has been implicated as a mode of transmission in nontuberculous mycobacterial (NTM) lung infections. Despite their importance, the diversity, distributions, and environmental predictors of showerhead-associated mycobacteria remain largely unresolved. To address these knowledge gaps, we worked with citizen scientists to collect showerhead biofilm samples and associated water chemistry data from 656 households located across the United States and Europe. Our cultivation-independent analyses revealed that the genus Mycobacterium was consistently the most abundant genus of bacteria detected in residential showerheads, and yet mycobacterial diversity and abundances were highly variable. Mycobacteria were far more abundant, on average, in showerheads receiving municipal water than in those receiving well water and in U.S. households than in European households, patterns that are likely driven by differences in the use of chlorine disinfectants. Moreover, we found that water source, water chemistry, and household location also influenced the prevalence of specific mycobacterial lineages detected in showerheads. We identified geographic regions within the United States where showerheads have particularly high abundances of potentially pathogenic lineages of mycobacteria, and these “hot spots” generally overlapped those regions where NTM lung disease is most prevalent. Together, these results emphasize the public health relevance of mycobacteria in showerhead biofilms. They further demonstrate that mycobacterial distributions in showerhead biofilms are often predictable from household location and water chemistry, knowledge that advances our understanding of NTM transmission dynamics and the development of strategies to reduce exposures to these emerging pathogens. Funding for this project was provided by the Innovative Research Program of the Cooperative Institute for Research in Environmental Sciences (N.F.), the High PlainsIntermountain Center for Agricultural Health & Safety (N.F.), the U.S. Department of Defense (N.F. and R.R.D.), and the Shoot for the Cure and Padosi Foundations (J.R.H.).M.D.-B. acknowledges support from the Marie Sklodowska-Curie Actions of the Horizon2020 Framework Program H2020-MSCA-IF-2016 under REA grant agreement no. 70205 Peer reviewed 2023-10-06T11:39:14Z 2023-10-06T11:39:14Z 2018-10-30 artículo mBio 9(5): e01614-18 (2018) 2161-2129 2150-7511 http://hdl.handle.net/10261/336743 10.1128/mBio.01614-18 30377276 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/H2020/70205 Publisher's version http://hdl.handle.net/10.1128/mBio.01614-18 Sí open American Society for Microbiology |
| institution |
IRNAS ES |
| collection |
DSpace |
| country |
España |
| countrycode |
ES |
| component |
Bibliográfico |
| access |
En linea |
| databasecode |
dig-irnas-es |
| tag |
biblioteca |
| region |
Europa del Sur |
| libraryname |
Biblioteca del IRNAS España |
| language |
English |
| topic |
Mycobacterium NTM lung disease Nontuberculous mycobacterial infection, plumbing biofilms Mycobacterium NTM lung disease Nontuberculous mycobacterial infection, plumbing biofilms |
| spellingShingle |
Mycobacterium NTM lung disease Nontuberculous mycobacterial infection, plumbing biofilms Mycobacterium NTM lung disease Nontuberculous mycobacterial infection, plumbing biofilms Gebert, Matthew J. Delgado-Baquerizo, Manuel Oliverio, Angela M. Webster, Tara M. Nichols, Lauren M. Honda, Jennifer R. Chan, Edward D. Adjemian, Jennifer Dunn, Robert R. Fierer, Noah Ecological Analyses of Mycobacteria in Showerhead Biofilms and Their Relevance to Human Health |
| description |
15 páginas.- 5 figuras.- 70 referencias.- Supplemental material for this article may be found at https://doi.org/10.1128/mBio.01614-18 |
| author2 |
Cooperative Institute for Research in Environmental Sciences (US) |
| author_facet |
Cooperative Institute for Research in Environmental Sciences (US) Gebert, Matthew J. Delgado-Baquerizo, Manuel Oliverio, Angela M. Webster, Tara M. Nichols, Lauren M. Honda, Jennifer R. Chan, Edward D. Adjemian, Jennifer Dunn, Robert R. Fierer, Noah |
| format |
artículo |
| topic_facet |
Mycobacterium NTM lung disease Nontuberculous mycobacterial infection, plumbing biofilms |
| author |
Gebert, Matthew J. Delgado-Baquerizo, Manuel Oliverio, Angela M. Webster, Tara M. Nichols, Lauren M. Honda, Jennifer R. Chan, Edward D. Adjemian, Jennifer Dunn, Robert R. Fierer, Noah |
| author_sort |
Gebert, Matthew J. |
| title |
Ecological Analyses of Mycobacteria in Showerhead Biofilms and Their Relevance to Human Health |
| title_short |
Ecological Analyses of Mycobacteria in Showerhead Biofilms and Their Relevance to Human Health |
| title_full |
Ecological Analyses of Mycobacteria in Showerhead Biofilms and Their Relevance to Human Health |
| title_fullStr |
Ecological Analyses of Mycobacteria in Showerhead Biofilms and Their Relevance to Human Health |
| title_full_unstemmed |
Ecological Analyses of Mycobacteria in Showerhead Biofilms and Their Relevance to Human Health |
| title_sort |
ecological analyses of mycobacteria in showerhead biofilms and their relevance to human health |
| publisher |
American Society for Microbiology |
| publishDate |
2018-10-30 |
| url |
http://hdl.handle.net/10261/336743 |
| work_keys_str_mv |
AT gebertmatthewj ecologicalanalysesofmycobacteriainshowerheadbiofilmsandtheirrelevancetohumanhealth AT delgadobaquerizomanuel ecologicalanalysesofmycobacteriainshowerheadbiofilmsandtheirrelevancetohumanhealth AT oliverioangelam ecologicalanalysesofmycobacteriainshowerheadbiofilmsandtheirrelevancetohumanhealth AT webstertaram ecologicalanalysesofmycobacteriainshowerheadbiofilmsandtheirrelevancetohumanhealth AT nicholslaurenm ecologicalanalysesofmycobacteriainshowerheadbiofilmsandtheirrelevancetohumanhealth AT hondajenniferr ecologicalanalysesofmycobacteriainshowerheadbiofilmsandtheirrelevancetohumanhealth AT chanedwardd ecologicalanalysesofmycobacteriainshowerheadbiofilmsandtheirrelevancetohumanhealth AT adjemianjennifer ecologicalanalysesofmycobacteriainshowerheadbiofilmsandtheirrelevancetohumanhealth AT dunnrobertr ecologicalanalysesofmycobacteriainshowerheadbiofilmsandtheirrelevancetohumanhealth AT fierernoah ecologicalanalysesofmycobacteriainshowerheadbiofilmsandtheirrelevancetohumanhealth |
| _version_ |
1781881217907425280 |