One-Pot Conversion of Proline Derivatives into Iodinated Iminosugar-Based Nucleosides, Useful Precursors of Highly Functionalized Nucleoside Analogues
1o páginas, 1 figura, 8 esquemas.
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| Format: | artículo biblioteca |
| Language: | English |
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Wiley-VCH
2010-12
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| Subjects: | Radical reactions, Amino acids, Nucleosides, Nitrogen heterocycles, Sequential processes, |
| Online Access: | http://hdl.handle.net/10261/39097 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100007273 |
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dig-ipna-es-10261-390972019-11-14T12:32:15Z One-Pot Conversion of Proline Derivatives into Iodinated Iminosugar-Based Nucleosides, Useful Precursors of Highly Functionalized Nucleoside Analogues Boto, Alicia Hernández, Dácil Hernández, Rosendo Ministerio de Educación y Ciencia (España) Ministerio de Ciencia e Innovación (España) Comisión Interministerial de Ciencia y Tecnología, CICYT (España) European Commission Gobierno de Canarias Biosigma Radical reactions Amino acids Nucleosides Nitrogen heterocycles Sequential processes 1o páginas, 1 figura, 8 esquemas. Readily available proline derivatives can be transformed in one step into β-iodinated iminosugar-based nucleosides, under very mild conditions. The method couples a tandem radical decarboxylation–oxidation–β-iodination to the addition of nitrogen bases. The iodo group is introduced into the previously unfunctionalized 3-position. The resultant β-iodo derivatives are useful precursors of highly functionalizednucleoside analogues. This work was supported by the Spanish Ministerio de Educación y Ciencia (MEC) and Ministerio de Ciencia e Innovación (MICINN), Investigation Programmes CTQ2006-14260/PPQ and CTQ2009-07109 of the Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica. The authors also acknowledge financial support from the European Regional Development Funds (FEDER funds). D. H. thanks the MEC for a fellowship and the Gobierno de Canarias (ACIISI)-BIOSIGMA SL for a research contract. Peer reviewed 2011-08-30T09:51:01Z 2011-08-30T09:51:01Z 2010-12 artículo http://purl.org/coar/resource_type/c_6501 European Journal of Organic Chemistry 34: 6633-6642 (2010) 1434-193X http://hdl.handle.net/10261/39097 10.1002/ejoc.201000997 1099-0690 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100007273 en http://dx.doi.org/10.1002/ejoc.201000997 none Wiley-VCH |
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IPNA ES |
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España |
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ES |
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Bibliográfico |
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dig-ipna-es |
| tag |
biblioteca |
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Europa del Sur |
| libraryname |
Biblioteca del IPNA España |
| language |
English |
| topic |
Radical reactions Amino acids Nucleosides Nitrogen heterocycles Sequential processes Radical reactions Amino acids Nucleosides Nitrogen heterocycles Sequential processes |
| spellingShingle |
Radical reactions Amino acids Nucleosides Nitrogen heterocycles Sequential processes Radical reactions Amino acids Nucleosides Nitrogen heterocycles Sequential processes Boto, Alicia Hernández, Dácil Hernández, Rosendo One-Pot Conversion of Proline Derivatives into Iodinated Iminosugar-Based Nucleosides, Useful Precursors of Highly Functionalized Nucleoside Analogues |
| description |
1o páginas, 1 figura, 8 esquemas. |
| author2 |
Ministerio de Educación y Ciencia (España) |
| author_facet |
Ministerio de Educación y Ciencia (España) Boto, Alicia Hernández, Dácil Hernández, Rosendo |
| format |
artículo |
| topic_facet |
Radical reactions Amino acids Nucleosides Nitrogen heterocycles Sequential processes |
| author |
Boto, Alicia Hernández, Dácil Hernández, Rosendo |
| author_sort |
Boto, Alicia |
| title |
One-Pot Conversion of Proline Derivatives into Iodinated Iminosugar-Based Nucleosides, Useful Precursors of Highly Functionalized Nucleoside Analogues |
| title_short |
One-Pot Conversion of Proline Derivatives into Iodinated Iminosugar-Based Nucleosides, Useful Precursors of Highly Functionalized Nucleoside Analogues |
| title_full |
One-Pot Conversion of Proline Derivatives into Iodinated Iminosugar-Based Nucleosides, Useful Precursors of Highly Functionalized Nucleoside Analogues |
| title_fullStr |
One-Pot Conversion of Proline Derivatives into Iodinated Iminosugar-Based Nucleosides, Useful Precursors of Highly Functionalized Nucleoside Analogues |
| title_full_unstemmed |
One-Pot Conversion of Proline Derivatives into Iodinated Iminosugar-Based Nucleosides, Useful Precursors of Highly Functionalized Nucleoside Analogues |
| title_sort |
one-pot conversion of proline derivatives into iodinated iminosugar-based nucleosides, useful precursors of highly functionalized nucleoside analogues |
| publisher |
Wiley-VCH |
| publishDate |
2010-12 |
| url |
http://hdl.handle.net/10261/39097 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100007273 |
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