Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Multidisciplinary Digital Publishing Institute
2024-03-02
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| Subjects: | Electrophilic compounds, polyphenols, hydrogen sulfide, NRF2/ARE axis, Keap1, organic sulfur, Michael acceptors, Ensure healthy lives and promote well-being for all at all ages, diet, electrophilic compounds, |
| Online Access: | http://hdl.handle.net/10261/352981 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100004837 |
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dig-ipna-es-10261-3529812024-05-14T11:36:37Z Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2 Curieses Andrés, Celia María Pérez de Lastra, José Manuel Bustamante Munguira, Elena Andrés Juan, Celia Plou Gasca, Francisco José Pérez Lebeña, Eduardo Ministerio de Economía y Competitividad (España) Ministerio de Ciencia e Innovación (España) Curieses Andrés, Celia María [0000-0003-4731-6398] Pérez de Lastra, José Manuel [0000-0003-4663-5565] Bustamante Munguira, Elena [0000-0002-5657-9547] Andrés Juan, Celia [0000-0003-1583-7439] Plou Gasca, Francisco José [0000-0003-0831-893X] Pérez Lebeña, Eduardo [0000-0002-5335-8175] Electrophilic compounds polyphenols hydrogen sulfide NRF2/ARE axis Keap1 organic sulfur Michael acceptors Ensure healthy lives and promote well-being for all at all ages diet electrophilic compounds © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). The phrase “Let food be thy medicine…” means that food can be a form of medicine and medicine can be a form of food; in other words, that the diet we eat can have a significant impact on our health and well-being. Today, this phrase is gaining prominence as more and more scientific evidence suggests that one’s diet can help prevent and treat disease. A diet rich in fruits, vegetables, whole grains, and lean protein can help reduce the risk of heart disease, cancer, diabetes, and other health problems and, on the other hand, a diet rich in processed foods, added sugars, and saturated fats can increase the risk of the same diseases. Electrophilic compounds in the diet can have a significant impact on our health, and they are molecules that covalently modify cysteine residues present in the thiol-rich Keap1 protein. These compounds bind to Keap1 and activate NRF2, which promotes its translocation to the nucleus and its binding to DNA in the ARE region, triggering the antioxidant response and protecting against oxidative stress. These compounds include polyphenols and flavonoids that are nucleophilic but are converted to electrophilic quinones by metabolic enzymes such as polyphenol oxidases (PPOs) and sulfur compounds present in foods such as the Brassica genus (broccoli, cauliflower, cabbage, Brussel sprouts, etc.) and garlic. This review summarizes our current knowledge on this subject. This research was funded by the Spanish Ministry of Economy and Competitiveness (Grant PID2019-105838RB-C31) and the State Plan for Scientific and Technical Research and Innovation 2021–2023 from the Spanish Ministry of Science and Innovation (project PLEC2022-009507). Peer reviewed 2024-04-05T09:56:11Z 2024-04-05T09:56:11Z 2024-03-02 artículo de revisión http://purl.org/coar/resource_type/c_dcae04bc International Journal of Molecular Sciences 25(6): 3521 (2024) http://hdl.handle.net/10261/352981 10.3390/ijms25063521 1422-0067 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100004837 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105838RB-C31/ES/SINTESIS ENZIMATICA, CARACTERIZACION Y BIOACTIVIDAD DE OLIGOSACARIDOS CARGADOS Y GLICOSIDOS DE POLIFENOLES/ info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PLEC2022-009507/ES/Caseinolytic Protease P (ClpP) Agonists: Small Molecules with a New Mechanism of Action for the Treatment of Multidrugs Resistant Bacterial Infections/ Publisher's version https://doi.org/10.3390/ijms25063521 Sí open application/pdf Multidisciplinary Digital Publishing Institute |
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Electrophilic compounds polyphenols hydrogen sulfide NRF2/ARE axis Keap1 organic sulfur Michael acceptors Ensure healthy lives and promote well-being for all at all ages diet electrophilic compounds Electrophilic compounds polyphenols hydrogen sulfide NRF2/ARE axis Keap1 organic sulfur Michael acceptors Ensure healthy lives and promote well-being for all at all ages diet electrophilic compounds |
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Electrophilic compounds polyphenols hydrogen sulfide NRF2/ARE axis Keap1 organic sulfur Michael acceptors Ensure healthy lives and promote well-being for all at all ages diet electrophilic compounds Electrophilic compounds polyphenols hydrogen sulfide NRF2/ARE axis Keap1 organic sulfur Michael acceptors Ensure healthy lives and promote well-being for all at all ages diet electrophilic compounds Curieses Andrés, Celia María Pérez de Lastra, José Manuel Bustamante Munguira, Elena Andrés Juan, Celia Plou Gasca, Francisco José Pérez Lebeña, Eduardo Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2 |
| description |
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| author2 |
Ministerio de Economía y Competitividad (España) |
| author_facet |
Ministerio de Economía y Competitividad (España) Curieses Andrés, Celia María Pérez de Lastra, José Manuel Bustamante Munguira, Elena Andrés Juan, Celia Plou Gasca, Francisco José Pérez Lebeña, Eduardo |
| format |
artículo de revisión |
| topic_facet |
Electrophilic compounds polyphenols hydrogen sulfide NRF2/ARE axis Keap1 organic sulfur Michael acceptors Ensure healthy lives and promote well-being for all at all ages diet electrophilic compounds |
| author |
Curieses Andrés, Celia María Pérez de Lastra, José Manuel Bustamante Munguira, Elena Andrés Juan, Celia Plou Gasca, Francisco José Pérez Lebeña, Eduardo |
| author_sort |
Curieses Andrés, Celia María |
| title |
Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2 |
| title_short |
Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2 |
| title_full |
Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2 |
| title_fullStr |
Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2 |
| title_full_unstemmed |
Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2 |
| title_sort |
electrophilic compounds in the human diet and their role in the induction of the transcription factor nrf2 |
| publisher |
Multidisciplinary Digital Publishing Institute |
| publishDate |
2024-03-02 |
| url |
http://hdl.handle.net/10261/352981 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100004837 |
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