Cellular landscaping of cisplatin resistance in cervical cancer
Cervical cancer (CC) caused by human papillomavirus (HPV) is one of the largest causes of malignancies in women worldwide. Cisplatin is one of the widely used drugs for the treatment of CC is rendered ineffective owing to drug resistance. This review highlights the cause of resistance and the mechanism of cisplatin resistance cells in CC to develop therapeutic ventures and strategies that could be utilized to overcome the aforementioned issue. These strategies would include the application of nanocarries, miRNA, CRIPSR/Cas system, and chemotherapeutics in synergy with cisplatin to not only overcome the issues of drug resistance but also enhance its anti-cancer efficiency. Moreover, we have also discussed the signaling network of cisplatin resistance cells in CC that would provide insights to develop therapeutic target sites and inhibitors. Furthermore, we have discussed the role of CC metabolism on cisplatin resistance cells and the physical and biological factors affecting the tumor microenvironments.
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Format: | artículo biblioteca |
Language: | English |
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Elsevier
2022-07-08
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Subjects: | Cervical cancer, cisplatin resistance, drug resistance, anti-cancer activity, chemotherapeutics, tumor microenvironment, cell signaling, |
Online Access: | http://hdl.handle.net/10261/279183 http://dx.doi.org/10.13039/501100007757 |
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dig-ipna-es-10261-2791832022-11-28T12:53:26Z Cellular landscaping of cisplatin resistance in cervical cancer Bhattacharjeea, Rahul Deya, Tanima Kumar, Lamha Kar, Sulagna Sarkar, Ritayan Ghorai, Mimosa Malik, Sumira Jha, Niraj K. Vellingiri, Balachandar Kumar Kesari, Kavindra Pérez de Lastra, José Manuel Dey, Abhijit Agencia Canaria de Investigación, Innovación y Sociedad de la Información Caja Canarias Cervical cancer cisplatin resistance drug resistance anti-cancer activity chemotherapeutics tumor microenvironment cell signaling Cervical cancer (CC) caused by human papillomavirus (HPV) is one of the largest causes of malignancies in women worldwide. Cisplatin is one of the widely used drugs for the treatment of CC is rendered ineffective owing to drug resistance. This review highlights the cause of resistance and the mechanism of cisplatin resistance cells in CC to develop therapeutic ventures and strategies that could be utilized to overcome the aforementioned issue. These strategies would include the application of nanocarries, miRNA, CRIPSR/Cas system, and chemotherapeutics in synergy with cisplatin to not only overcome the issues of drug resistance but also enhance its anti-cancer efficiency. Moreover, we have also discussed the signaling network of cisplatin resistance cells in CC that would provide insights to develop therapeutic target sites and inhibitors. Furthermore, we have discussed the role of CC metabolism on cisplatin resistance cells and the physical and biological factors affecting the tumor microenvironments. This research was funded by “Agencia Canaria de Investigación, Innovación y Sociedad de la Información (ACIISI) del Gobierno de Canarias” (project ProID2020010134), and CajaCanarias (project 2019SP43). The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. Peer reviewed 2022-09-15T09:14:13Z 2022-09-15T09:14:13Z 2022-07-08 artículo Biomedicine and Pharmacotherapy, 153, 113345: 1-18 (2022) 0753-3322 http://hdl.handle.net/10261/279183 10.1016/j.biopha.2022.113345 http://dx.doi.org/10.13039/501100007757 en Publisher's version https://doi.org/10.1016/j.biopha.2022.113345 Sí open Elsevier |
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Cervical cancer cisplatin resistance drug resistance anti-cancer activity chemotherapeutics tumor microenvironment cell signaling Cervical cancer cisplatin resistance drug resistance anti-cancer activity chemotherapeutics tumor microenvironment cell signaling |
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Cervical cancer cisplatin resistance drug resistance anti-cancer activity chemotherapeutics tumor microenvironment cell signaling Cervical cancer cisplatin resistance drug resistance anti-cancer activity chemotherapeutics tumor microenvironment cell signaling Bhattacharjeea, Rahul Deya, Tanima Kumar, Lamha Kar, Sulagna Sarkar, Ritayan Ghorai, Mimosa Malik, Sumira Jha, Niraj K. Vellingiri, Balachandar Kumar Kesari, Kavindra Pérez de Lastra, José Manuel Dey, Abhijit Cellular landscaping of cisplatin resistance in cervical cancer |
description |
Cervical cancer (CC) caused by human papillomavirus (HPV) is one of the largest causes of malignancies in women worldwide. Cisplatin is one of the widely used drugs for the treatment of CC is rendered ineffective owing to drug resistance. This review highlights the cause of resistance and the mechanism of cisplatin resistance cells in CC to develop therapeutic ventures and strategies that could be utilized to overcome the aforementioned issue. These strategies would include the application of nanocarries, miRNA, CRIPSR/Cas system, and chemotherapeutics in synergy with cisplatin to not only overcome the issues of drug resistance but also enhance its anti-cancer efficiency. Moreover, we have also discussed the signaling network of cisplatin resistance cells in CC that would provide insights to develop therapeutic target sites and inhibitors. Furthermore, we have discussed the role of CC metabolism on cisplatin resistance cells and the physical and biological factors affecting the tumor microenvironments. |
author2 |
Agencia Canaria de Investigación, Innovación y Sociedad de la Información |
author_facet |
Agencia Canaria de Investigación, Innovación y Sociedad de la Información Bhattacharjeea, Rahul Deya, Tanima Kumar, Lamha Kar, Sulagna Sarkar, Ritayan Ghorai, Mimosa Malik, Sumira Jha, Niraj K. Vellingiri, Balachandar Kumar Kesari, Kavindra Pérez de Lastra, José Manuel Dey, Abhijit |
format |
artículo |
topic_facet |
Cervical cancer cisplatin resistance drug resistance anti-cancer activity chemotherapeutics tumor microenvironment cell signaling |
author |
Bhattacharjeea, Rahul Deya, Tanima Kumar, Lamha Kar, Sulagna Sarkar, Ritayan Ghorai, Mimosa Malik, Sumira Jha, Niraj K. Vellingiri, Balachandar Kumar Kesari, Kavindra Pérez de Lastra, José Manuel Dey, Abhijit |
author_sort |
Bhattacharjeea, Rahul |
title |
Cellular landscaping of cisplatin resistance in cervical cancer |
title_short |
Cellular landscaping of cisplatin resistance in cervical cancer |
title_full |
Cellular landscaping of cisplatin resistance in cervical cancer |
title_fullStr |
Cellular landscaping of cisplatin resistance in cervical cancer |
title_full_unstemmed |
Cellular landscaping of cisplatin resistance in cervical cancer |
title_sort |
cellular landscaping of cisplatin resistance in cervical cancer |
publisher |
Elsevier |
publishDate |
2022-07-08 |
url |
http://hdl.handle.net/10261/279183 http://dx.doi.org/10.13039/501100007757 |
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