Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics
Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that cause millions of deaths every year. With the new understanding of the molecular mechanism(s) of disease progression, our knowledge about the disease is snowballing, leading to the evolution of many new therapeutic regimes and their successive trials. In the past few decades, various combinations of therapies have been proposed and are presently employed in the treatment of diverse cancers. Targeted drug therapy, immunotherapy, and personalized medicines are now largely being employed, which were not common a few years back. The field of cancer discoveries and therapeutics are evolving fast as cancer type-specific biomarkers are progressively being identified and several types of cancers are nowadays undergoing systematic therapies, extending patients’ disease-free survival thereafter. Although growing evidence shows that a systematic and targeted approach could be the future of cancer medicine, chemotherapy remains a largely opted therapeutic option despite its known side effects on the patient’s physical and psychological health. Chemotherapeutic agents/pharmaceuticals served a great purpose over the past few decades and have remained the frontline choice for advanced-stage malignancies where surgery and/or radiation therapy cannot be prescribed due to specific reasons. The present report succinctly reviews the existing and contemporary advancements in chemotherapy and assesses the status of the enrolled drugs/pharmaceuticals; it also comprehensively discusses the emerging role of specific/targeted therapeutic strategies that are presently being employed to achieve better clinical success/survival rate in cancer patients.
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Elsevier
2022-03-18
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Subjects: | Antimicrobial peptides, cancer therapies, clinical trials, combination therapy, immunotherapy, patient survival, personalized medicine, targeted drug delivery, |
Online Access: | http://hdl.handle.net/10261/269124 http://dx.doi.org/10.13039/501100007757 |
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dig-ipna-es-10261-2691242022-11-28T13:31:50Z Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics Anand, Uttpal Dey, Abhijit Chandel, Arvind K. Singh Sanyal, Rupa Mishra, Amarnath Pandey, Devendra Kumar De Falco, Valentina Upadhyay, Arun Kandimalla, Ramesh Chaudhary, Anupama Dhanjal, Jaspreet Kaur Dewanjee, Saikat Vallamkondu, Jayalakshmi Pérez de Lastra, José Manuel Agencia Canaria de Investigación, Innovación y Sociedad de la Información Gobierno de Canarias Caja Canarias Antimicrobial peptides cancer therapies clinical trials combination therapy immunotherapy patient survival personalized medicine targeted drug delivery Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that cause millions of deaths every year. With the new understanding of the molecular mechanism(s) of disease progression, our knowledge about the disease is snowballing, leading to the evolution of many new therapeutic regimes and their successive trials. In the past few decades, various combinations of therapies have been proposed and are presently employed in the treatment of diverse cancers. Targeted drug therapy, immunotherapy, and personalized medicines are now largely being employed, which were not common a few years back. The field of cancer discoveries and therapeutics are evolving fast as cancer type-specific biomarkers are progressively being identified and several types of cancers are nowadays undergoing systematic therapies, extending patients’ disease-free survival thereafter. Although growing evidence shows that a systematic and targeted approach could be the future of cancer medicine, chemotherapy remains a largely opted therapeutic option despite its known side effects on the patient’s physical and psychological health. Chemotherapeutic agents/pharmaceuticals served a great purpose over the past few decades and have remained the frontline choice for advanced-stage malignancies where surgery and/or radiation therapy cannot be prescribed due to specific reasons. The present report succinctly reviews the existing and contemporary advancements in chemotherapy and assesses the status of the enrolled drugs/pharmaceuticals; it also comprehensively discusses the emerging role of specific/targeted therapeutic strategies that are presently being employed to achieve better clinical success/survival rate in cancer patients. All the authors are highly grateful and acknowledge to the authority of the respective departments and institutions for their support in carrying out this research. The authors also express their sincere gratitude to the unknown referee for critically reviewing the manuscript and suggesting useful changes. This research was funded by "Agencia Canaria de Investigación, Innovación y Sociedad de la Información (ACIISI) del Gobierno de Canarias” (No. ProID2020010134), and o´Caja Canarias (Project No. 2019SP43). Peer reviewed 2022-05-10T08:29:44Z 2022-05-10T08:29:44Z 2022-03-18 artículo de revisión http://purl.org/coar/resource_type/c_dcae04bc Genes & Diseases : 1-35 (2022) http://hdl.handle.net/10261/269124 10.1016/j.gendis.2022.02.007 2352-3042 http://dx.doi.org/10.13039/501100007757 en Publisher's version https://doi.org/10.1016/j.gendis.2022.02.007 Sí open Elsevier |
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Antimicrobial peptides cancer therapies clinical trials combination therapy immunotherapy patient survival personalized medicine targeted drug delivery Antimicrobial peptides cancer therapies clinical trials combination therapy immunotherapy patient survival personalized medicine targeted drug delivery |
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Antimicrobial peptides cancer therapies clinical trials combination therapy immunotherapy patient survival personalized medicine targeted drug delivery Antimicrobial peptides cancer therapies clinical trials combination therapy immunotherapy patient survival personalized medicine targeted drug delivery Anand, Uttpal Dey, Abhijit Chandel, Arvind K. Singh Sanyal, Rupa Mishra, Amarnath Pandey, Devendra Kumar De Falco, Valentina Upadhyay, Arun Kandimalla, Ramesh Chaudhary, Anupama Dhanjal, Jaspreet Kaur Dewanjee, Saikat Vallamkondu, Jayalakshmi Pérez de Lastra, José Manuel Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics |
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Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that cause millions of deaths every year. With the new understanding of the molecular mechanism(s) of disease progression, our knowledge about the disease is snowballing, leading to the evolution of many new therapeutic regimes and their successive trials. In the past few decades, various combinations of therapies have been proposed and are presently employed in the treatment of diverse cancers. Targeted drug therapy, immunotherapy, and personalized medicines are now largely being employed, which were not common a few years back. The field of cancer discoveries and therapeutics are evolving fast as cancer type-specific biomarkers are progressively being identified and several types of cancers are nowadays undergoing systematic therapies, extending patients’ disease-free survival thereafter. Although growing evidence shows that a systematic and targeted approach could be the future of cancer medicine, chemotherapy remains a largely opted therapeutic option despite its known side effects on the patient’s physical and psychological health. Chemotherapeutic agents/pharmaceuticals served a great purpose over the past few decades and have remained the frontline choice for advanced-stage malignancies where surgery and/or radiation therapy cannot be prescribed due to specific reasons. The present report succinctly reviews the existing and contemporary advancements in chemotherapy and assesses the status of the enrolled drugs/pharmaceuticals; it also comprehensively discusses the emerging role of specific/targeted therapeutic strategies that are presently being employed to achieve better clinical success/survival rate in cancer patients. |
author2 |
Agencia Canaria de Investigación, Innovación y Sociedad de la Información |
author_facet |
Agencia Canaria de Investigación, Innovación y Sociedad de la Información Anand, Uttpal Dey, Abhijit Chandel, Arvind K. Singh Sanyal, Rupa Mishra, Amarnath Pandey, Devendra Kumar De Falco, Valentina Upadhyay, Arun Kandimalla, Ramesh Chaudhary, Anupama Dhanjal, Jaspreet Kaur Dewanjee, Saikat Vallamkondu, Jayalakshmi Pérez de Lastra, José Manuel |
format |
artículo de revisión |
topic_facet |
Antimicrobial peptides cancer therapies clinical trials combination therapy immunotherapy patient survival personalized medicine targeted drug delivery |
author |
Anand, Uttpal Dey, Abhijit Chandel, Arvind K. Singh Sanyal, Rupa Mishra, Amarnath Pandey, Devendra Kumar De Falco, Valentina Upadhyay, Arun Kandimalla, Ramesh Chaudhary, Anupama Dhanjal, Jaspreet Kaur Dewanjee, Saikat Vallamkondu, Jayalakshmi Pérez de Lastra, José Manuel |
author_sort |
Anand, Uttpal |
title |
Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics |
title_short |
Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics |
title_full |
Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics |
title_fullStr |
Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics |
title_full_unstemmed |
Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics |
title_sort |
cancer chemotherapy and beyond: current status, drug candidates, associated risks and progress in targeted therapeutics |
publisher |
Elsevier |
publishDate |
2022-03-18 |
url |
http://hdl.handle.net/10261/269124 http://dx.doi.org/10.13039/501100007757 |
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