Adriatoxin-B, the first C13 terminal truncated YTX analogue obtained from dinoflagellates

Adriatoxin-B, the first C13 terminal truncated YTX analogue obtained from dinoflagellates

Adriatoxin-B (ATX-B) is the first C13 terminal truncated YTX analogous metabolite that was isolated from large-scale cultures of the dinoflagellate Protoceratium reticulatum. The structure and conformational behavior of ATX-B was elucidated by a combination of NMR spectroscopy experiments and a conformational analysis. The isolation of this metabolite, which possesses a clear structural relationship with adriatoxin, supports the idea that the real source of these cut down substances is in the microalgae and not in the mollusks, via metabolic degradation like it has been assumed until now.

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Bibliographic Details
Main Authors: Domínguez, Humberto J., Souto, María L., Norte, Manuel, Hernández Daranas, Antonio, Fernández, José J.
Other Authors: Ministerio de Educación y Cultura (España)
Format: artículo biblioteca
Language:English
Published: Elsevier 2010-07-06
Subjects:Adriatoxin, Yessotoxin, Marine toxins, DSP syndrome, Marine polyethers,
Online Access:http://hdl.handle.net/10261/213301
http://dx.doi.org/10.13039/501100011034
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spelling dig-ipna-es-10261-2133012020-06-05T01:10:57Z Adriatoxin-B, the first C13 terminal truncated YTX analogue obtained from dinoflagellates Domínguez, Humberto J. Souto, María L. Norte, Manuel Hernández Daranas, Antonio Fernández, José J. Ministerio de Educación y Cultura (España) CSIC - Instituto Español de Oceanografía (IEO) Adriatoxin Yessotoxin Marine toxins DSP syndrome Marine polyethers Adriatoxin-B (ATX-B) is the first C13 terminal truncated YTX analogous metabolite that was isolated from large-scale cultures of the dinoflagellate Protoceratium reticulatum. The structure and conformational behavior of ATX-B was elucidated by a combination of NMR spectroscopy experiments and a conformational analysis. The isolation of this metabolite, which possesses a clear structural relationship with adriatoxin, supports the idea that the real source of these cut down substances is in the microalgae and not in the mollusks, via metabolic degradation like it has been assumed until now. Peer reviewed 2020-06-04T07:56:22Z 2020-06-04T07:56:22Z 2010-07-06 artículo http://purl.org/coar/resource_type/c_6501 Toxicon 55(8): 1484-1490 (2010) 0041-0101 10.1016/j.toxicon.2010.02.029 http://hdl.handle.net/10261/213301 1879-3150 http://dx.doi.org/10.13039/501100011034 en Postprint https://doi.org/10.1016/j.toxicon.2010.02.029 No none Elsevier
institution IPNA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-ipna-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IPNA España
language English
topic Adriatoxin
Yessotoxin
Marine toxins
DSP syndrome
Marine polyethers
Adriatoxin
Yessotoxin
Marine toxins
DSP syndrome
Marine polyethers
spellingShingle Adriatoxin
Yessotoxin
Marine toxins
DSP syndrome
Marine polyethers
Adriatoxin
Yessotoxin
Marine toxins
DSP syndrome
Marine polyethers
Domínguez, Humberto J.
Souto, María L.
Norte, Manuel
Hernández Daranas, Antonio
Fernández, José J.
Adriatoxin-B, the first C13 terminal truncated YTX analogue obtained from dinoflagellates
description Adriatoxin-B (ATX-B) is the first C13 terminal truncated YTX analogous metabolite that was isolated from large-scale cultures of the dinoflagellate Protoceratium reticulatum. The structure and conformational behavior of ATX-B was elucidated by a combination of NMR spectroscopy experiments and a conformational analysis. The isolation of this metabolite, which possesses a clear structural relationship with adriatoxin, supports the idea that the real source of these cut down substances is in the microalgae and not in the mollusks, via metabolic degradation like it has been assumed until now.
author2 Ministerio de Educación y Cultura (España)
author_facet Ministerio de Educación y Cultura (España)
Domínguez, Humberto J.
Souto, María L.
Norte, Manuel
Hernández Daranas, Antonio
Fernández, José J.
format artículo
topic_facet Adriatoxin
Yessotoxin
Marine toxins
DSP syndrome
Marine polyethers
author Domínguez, Humberto J.
Souto, María L.
Norte, Manuel
Hernández Daranas, Antonio
Fernández, José J.
author_sort Domínguez, Humberto J.
title Adriatoxin-B, the first C13 terminal truncated YTX analogue obtained from dinoflagellates
title_short Adriatoxin-B, the first C13 terminal truncated YTX analogue obtained from dinoflagellates
title_full Adriatoxin-B, the first C13 terminal truncated YTX analogue obtained from dinoflagellates
title_fullStr Adriatoxin-B, the first C13 terminal truncated YTX analogue obtained from dinoflagellates
title_full_unstemmed Adriatoxin-B, the first C13 terminal truncated YTX analogue obtained from dinoflagellates
title_sort adriatoxin-b, the first c13 terminal truncated ytx analogue obtained from dinoflagellates
publisher Elsevier
publishDate 2010-07-06
url http://hdl.handle.net/10261/213301
http://dx.doi.org/10.13039/501100011034
work_keys_str_mv AT dominguezhumbertoj adriatoxinbthefirstc13terminaltruncatedytxanalogueobtainedfromdinoflagellates
AT soutomarial adriatoxinbthefirstc13terminaltruncatedytxanalogueobtainedfromdinoflagellates
AT nortemanuel adriatoxinbthefirstc13terminaltruncatedytxanalogueobtainedfromdinoflagellates
AT hernandezdaranasantonio adriatoxinbthefirstc13terminaltruncatedytxanalogueobtainedfromdinoflagellates
AT fernandezjosej adriatoxinbthefirstc13terminaltruncatedytxanalogueobtainedfromdinoflagellates
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