Iron(III)-catalyzed halogenations by substitution of sulfonate esters

A novel halogenation reaction from sulfonates catalyzed by iron(III) is described. The reaction can be performed as a stoichiometric or a catalytic version. This reaction provides a convenient strategy for the efficient access to structurally diverse secondary chlorides, bromides and iodides. The stereochemical course of the reaction is governed by the substrate and the experimental conditions. Secondary alcohols modified as quisylates or pysylates are substantially more reactive. Aliphatic quisylates proceed with overall inversion of configuration under catalytic conditions. Chemoselectivity in bismesylates was observed in favour of the secondary mesylate. Additionally, based on the experimental results, a possible catalytic cycle for the halogenation has been proposed.

Bibliographic Details

Main Authors:	Ortega, Nuria, Feher-Voelger, Andrés, Brovetto, Margarita, Padrón, Juan I., Martín, Víctor S., Martín, Tomás
Other Authors:	Ministerio de Ciencia e Innovación (España)
Format:	artículo biblioteca
Published:	Wiley-VCH 2011-4-18
Subjects:	Catalysis, Halogenation: Iron, Leaving, Groups, Substitution,
Online Access:	http://hdl.handle.net/10261/199769 http://dx.doi.org/10.13039/501100007757 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003339
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