Phenolic metabolites, biological activities, and isolated compounds of Terminalia muelleri extract
© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
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Taylor & Francis
2017-11-27
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| Subjects: | Anticancer, Antioxidant, DPPH, Molecular docking, |
| Online Access: | http://hdl.handle.net/10261/185204 |
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dig-ipna-es-10261-1852042021-12-28T16:11:09Z Phenolic metabolites, biological activities, and isolated compounds of Terminalia muelleri extract El-Kashak, Walaa A. Osman, Samir M. Gaara, Ahmed H. El-Toumy, Sayed A. Mohamed, Tahia K. Brouard, Ignacio Anticancer Antioxidant DPPH Molecular docking © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. [Context]: Terminalia muelleri Benth. (Combretaceae), is rich with phenolics that have antioxidant and cytotoxic activities. No screening studies were published before on T. muelleri. [Objective]: The study focused on isolation and identification of secondary metabolites from aqueous methanol leaf extract of T. muelleri and evaluation of its biological activities. [Materials and methods]: The n-butanol extract was chromatographed on polyamide 6, and eluted with H2O/MeOH mixtures of decreasing polarity, then separated by different chromatographic tools that yielded 10 phenolic compounds. The antioxidant activity of the extract was evaluated by investigating its total phenolic and flavonoid content and DPPH scavenging effectiveness. The extract and the two acylated flavones were evaluated for their anticancer activity towards MCF-7 and PC3 cancer cell lines. Molecular docking study of the acylated flavones was performed against topoisomerase enzyme. [Results and discussion]: Two acylated flavonoids, apigenin-8-C-(2″-O-galloyl) glucoside 1 and luteolin-8-C-(2″-O-galloyl) glucoside 2, were isolated and identified for the second time in nature, with eight tannins (3–10), from the leaves of T. muelleri. The extract and compound 10 showed the most significant antioxidant activity (IC50 = 3.55 and 6.34 μg/mL), respectively. The total extract and compound 2 demonstrated cytotoxic effect against MCF-7 with IC50 = 29.7 and 45.2 μg/mL respectively, while compound 1 showed cytotoxic effect against PC3 (IC50 = 40.8 μg/mL). The docking study of compounds 1 and 2 confirmed unique binding mode in the active site of human DNA topoisomerase enzyme. [Conclusions]: Terminalia muelleri is a promising medicinal plant as it possesses high antioxidant activity and moderate cytotoxic activity against MCF-7. Peer Reviewed 2019-07-01T10:48:45Z 2019-07-01T10:48:45Z 2017-11-27 2019-07-01T10:48:45Z artículo http://purl.org/coar/resource_type/c_6501 Pharmaceutical Biology 55(1): 2277-2284 (2017) 1388-0209 http://hdl.handle.net/10261/185204 10.1080/13880209.2017.1406531 1744-5116 29179615 Publisher's version https://doi.org/10.1080/13880209.2017.1406531 open Taylor & Francis |
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Anticancer Antioxidant DPPH Molecular docking Anticancer Antioxidant DPPH Molecular docking |
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Anticancer Antioxidant DPPH Molecular docking Anticancer Antioxidant DPPH Molecular docking El-Kashak, Walaa A. Osman, Samir M. Gaara, Ahmed H. El-Toumy, Sayed A. Mohamed, Tahia K. Brouard, Ignacio Phenolic metabolites, biological activities, and isolated compounds of Terminalia muelleri extract |
| description |
© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. |
| format |
artículo |
| topic_facet |
Anticancer Antioxidant DPPH Molecular docking |
| author |
El-Kashak, Walaa A. Osman, Samir M. Gaara, Ahmed H. El-Toumy, Sayed A. Mohamed, Tahia K. Brouard, Ignacio |
| author_facet |
El-Kashak, Walaa A. Osman, Samir M. Gaara, Ahmed H. El-Toumy, Sayed A. Mohamed, Tahia K. Brouard, Ignacio |
| author_sort |
El-Kashak, Walaa A. |
| title |
Phenolic metabolites, biological activities, and isolated compounds of Terminalia muelleri extract |
| title_short |
Phenolic metabolites, biological activities, and isolated compounds of Terminalia muelleri extract |
| title_full |
Phenolic metabolites, biological activities, and isolated compounds of Terminalia muelleri extract |
| title_fullStr |
Phenolic metabolites, biological activities, and isolated compounds of Terminalia muelleri extract |
| title_full_unstemmed |
Phenolic metabolites, biological activities, and isolated compounds of Terminalia muelleri extract |
| title_sort |
phenolic metabolites, biological activities, and isolated compounds of terminalia muelleri extract |
| publisher |
Taylor & Francis |
| publishDate |
2017-11-27 |
| url |
http://hdl.handle.net/10261/185204 |
| work_keys_str_mv |
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