A convenient entry to 5-sp2-substituted and 5,5-disubstituted tetronic acids
3 pages, 1 figure, 1 table, 2 schemes.
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| Format: | artículo biblioteca |
| Language: | English |
| Published: |
Thieme
2006-06-12
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| Subjects: | Alkynes, Lactones, Aminations, Cyclizations, Michael additions, |
| Online Access: | http://hdl.handle.net/10261/13273 http://dx.doi.org/10.13039/501100000780 |
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dig-ipna-es-10261-132732019-11-12T14:22:14Z A convenient entry to 5-sp2-substituted and 5,5-disubstituted tetronic acids Tejedor, David Santos-Expósito, Alicia García-Tellado, Fernando Ministerio de Educación y Ciencia (España) European Commission Instituto Canario de Investigación del Cáncer Alkynes Lactones Aminations Cyclizations Michael additions 3 pages, 1 figure, 1 table, 2 schemes. A one-pot, convenient and general access to 5-sp2-substituted and 5,5-disubstituted tetronic acids is described. The protocol embodies two consecutive chemical events: a Michael addition of pyrrolidine on a secondary or tertiary γ-hydroxy-α,β-alkynyl ester derivative to give the corresponding enamine, and the subsequent acid-catalyzed hydrolysis-lactonization of this intermediate to afford the tetronic acid derivative. This research was supported by the Spanish Ministerio de Educación y Ciencia and the European Regional Development Fund (CTQ2005-09074-C02-02). F.G.T. thanks the Instituto Canario de Investigación del Cáncer for financial support (ICIC-GI nº 10/2005: ISCiii, RTICCC C03/10). 2009-05-28T07:16:21Z 2009-05-28T07:16:21Z 2006-06-12 artículo http://purl.org/coar/resource_type/c_6501 Synlett 2006(10): 1607-1609 (2006) 0936-5214 http://hdl.handle.net/10261/13273 10.1055/s-2006-941596 http://dx.doi.org/10.13039/501100000780 en http://dx.doi.org/10.1055/s-2006-941596 none 2373 bytes 73435 bytes text/plain application/pdf Thieme |
| institution |
IPNA ES |
| collection |
DSpace |
| country |
España |
| countrycode |
ES |
| component |
Bibliográfico |
| access |
En linea |
| databasecode |
dig-ipna-es |
| tag |
biblioteca |
| region |
Europa del Sur |
| libraryname |
Biblioteca del IPNA España |
| language |
English |
| topic |
Alkynes Lactones Aminations Cyclizations Michael additions Alkynes Lactones Aminations Cyclizations Michael additions |
| spellingShingle |
Alkynes Lactones Aminations Cyclizations Michael additions Alkynes Lactones Aminations Cyclizations Michael additions Tejedor, David Santos-Expósito, Alicia García-Tellado, Fernando A convenient entry to 5-sp2-substituted and 5,5-disubstituted tetronic acids |
| description |
3 pages, 1 figure, 1 table, 2 schemes. |
| author2 |
Ministerio de Educación y Ciencia (España) |
| author_facet |
Ministerio de Educación y Ciencia (España) Tejedor, David Santos-Expósito, Alicia García-Tellado, Fernando |
| format |
artículo |
| topic_facet |
Alkynes Lactones Aminations Cyclizations Michael additions |
| author |
Tejedor, David Santos-Expósito, Alicia García-Tellado, Fernando |
| author_sort |
Tejedor, David |
| title |
A convenient entry to 5-sp2-substituted and 5,5-disubstituted tetronic acids |
| title_short |
A convenient entry to 5-sp2-substituted and 5,5-disubstituted tetronic acids |
| title_full |
A convenient entry to 5-sp2-substituted and 5,5-disubstituted tetronic acids |
| title_fullStr |
A convenient entry to 5-sp2-substituted and 5,5-disubstituted tetronic acids |
| title_full_unstemmed |
A convenient entry to 5-sp2-substituted and 5,5-disubstituted tetronic acids |
| title_sort |
convenient entry to 5-sp2-substituted and 5,5-disubstituted tetronic acids |
| publisher |
Thieme |
| publishDate |
2006-06-12 |
| url |
http://hdl.handle.net/10261/13273 http://dx.doi.org/10.13039/501100000780 |
| work_keys_str_mv |
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| _version_ |
1777669625415204864 |