The human milk microbiota Origin and potential roles in health and disease
Human milk has been traditionally considered sterile; however, recent studies have shown that it represents a continuous supply of commensal, mutualistic and/or potentially probiotic bacteria to the infant gut. Culture-dependent and -independent techniques have revealed the dominance of staphylococci, streptococci, lactic acid bacteria and bifidobacteria in this biological fluid, and their role on the colonization of the infant gut. These bacteria could protect the infant against infections and contribute to the maturation of the immune system, among other functions. Different studies suggest that some bacteria present in the maternal gut could reach the mammary gland during late pregnancy and lactation through a mechanism involving gut monocytes. Thus, modulation of maternal gut microbiota during pregnancy and lactation could have a direct effect on infant health. On the other hand, mammary dysbiosis may lead to mastitis, a condition that represents the first medical cause for undesired weaning. Selected strains isolated from breast milk can be good candidates for use as probiotics. In this review, their potential uses for the treatment of mastitis and to inhibit mother-to-infant transfer of HIV are discussed. © 2012 Elsevier Ltd. All Rights Reserved.
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dig-inia-es-20.500.12792-50822020-12-15T09:55:01Z The human milk microbiota Origin and potential roles in health and disease Fernández, L. Langa, S. Martín, V. Maldonado, A. Jiménez, E. Martín, R. Rodríguez, J. M. Human milk has been traditionally considered sterile; however, recent studies have shown that it represents a continuous supply of commensal, mutualistic and/or potentially probiotic bacteria to the infant gut. Culture-dependent and -independent techniques have revealed the dominance of staphylococci, streptococci, lactic acid bacteria and bifidobacteria in this biological fluid, and their role on the colonization of the infant gut. These bacteria could protect the infant against infections and contribute to the maturation of the immune system, among other functions. Different studies suggest that some bacteria present in the maternal gut could reach the mammary gland during late pregnancy and lactation through a mechanism involving gut monocytes. Thus, modulation of maternal gut microbiota during pregnancy and lactation could have a direct effect on infant health. On the other hand, mammary dysbiosis may lead to mastitis, a condition that represents the first medical cause for undesired weaning. Selected strains isolated from breast milk can be good candidates for use as probiotics. In this review, their potential uses for the treatment of mastitis and to inhibit mother-to-infant transfer of HIV are discussed. © 2012 Elsevier Ltd. All Rights Reserved. 2020-10-22T18:57:15Z 2020-10-22T18:57:15Z 2013 review http://hdl.handle.net/20.500.12792/5082 10.1016/j.phrs.2012.09.001 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ open access |
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Human milk has been traditionally considered sterile; however, recent studies have shown that it represents a continuous supply of commensal, mutualistic and/or potentially probiotic bacteria to the infant gut. Culture-dependent and -independent techniques have revealed the dominance of staphylococci, streptococci, lactic acid bacteria and bifidobacteria in this biological fluid, and their role on the colonization of the infant gut. These bacteria could protect the infant against infections and contribute to the maturation of the immune system, among other functions. Different studies suggest that some bacteria present in the maternal gut could reach the mammary gland during late pregnancy and lactation through a mechanism involving gut monocytes. Thus, modulation of maternal gut microbiota during pregnancy and lactation could have a direct effect on infant health. On the other hand, mammary dysbiosis may lead to mastitis, a condition that represents the first medical cause for undesired weaning. Selected strains isolated from breast milk can be good candidates for use as probiotics. In this review, their potential uses for the treatment of mastitis and to inhibit mother-to-infant transfer of HIV are discussed. © 2012 Elsevier Ltd. All Rights Reserved. |
format |
review |
author |
Fernández, L. Langa, S. Martín, V. Maldonado, A. Jiménez, E. Martín, R. Rodríguez, J. M. |
spellingShingle |
Fernández, L. Langa, S. Martín, V. Maldonado, A. Jiménez, E. Martín, R. Rodríguez, J. M. The human milk microbiota Origin and potential roles in health and disease |
author_facet |
Fernández, L. Langa, S. Martín, V. Maldonado, A. Jiménez, E. Martín, R. Rodríguez, J. M. |
author_sort |
Fernández, L. |
title |
The human milk microbiota Origin and potential roles in health and disease |
title_short |
The human milk microbiota Origin and potential roles in health and disease |
title_full |
The human milk microbiota Origin and potential roles in health and disease |
title_fullStr |
The human milk microbiota Origin and potential roles in health and disease |
title_full_unstemmed |
The human milk microbiota Origin and potential roles in health and disease |
title_sort |
human milk microbiota origin and potential roles in health and disease |
publishDate |
2013 |
url |
http://hdl.handle.net/20.500.12792/5082 |
work_keys_str_mv |
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