Analyses of monoclonal antibodies reacting with porcine CD5 Results from the Second International Swine CD Workshop

Analyses of monoclonal antibodies reacting with porcine CD5 Results from the Second International Swine CD Workshop

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Among the 57 monoclonal antibodies analyzed within the T-cell group, three mAbs fell within cluster T13 including the CD5a standard b53b7 (No. 174). The two new mAbs 1H6/8 (No. 058) and BB6-9G12 (No. 166) both precipitated 55 and 60 kDa proteins that were of similar molecular weights as the standard. Staining patterns on the various cell types were similar. Both new antibodies inhibited the binding of the CD5a reference mAbs b53b7 to peripheral lymphocytes. These mAbs, therefore both react with the CD5a epitope bringing the number of anti-porcine CD5 mAbs to eight, all of which appear to recognize the same epitope.

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Main Authors: Pescovitz, M. D., Book, B. K., Aasted, B., Dominguez, J., Bullido, R., Trebichavsky, I., Novikov, B., Valpotic, I., Tomaskovic, M., Nielsen, J., Arn, S., Sachs, D. H., Lunney, J. K., Boyd, P. C., Walker, J., Lee, R., Saalmüller, A.
Format: conference object biblioteca
Language:eng
Published: 1998
Online Access:http://hdl.handle.net/20.500.12792/3491
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spelling dig-inia-es-20.500.12792-34912020-12-15T09:54:30Z Analyses of monoclonal antibodies reacting with porcine CD5 Results from the Second International Swine CD Workshop Pescovitz, M. D. Book, B. K. Aasted, B. Dominguez, J. Bullido, R. Trebichavsky, I. Novikov, B. Valpotic, I. Tomaskovic, M. Nielsen, J. Arn, S. Sachs, D. H. Lunney, J. K. Boyd, P. C. Walker, J. Lee, R. Saalmüller, A. Among the 57 monoclonal antibodies analyzed within the T-cell group, three mAbs fell within cluster T13 including the CD5a standard b53b7 (No. 174). The two new mAbs 1H6/8 (No. 058) and BB6-9G12 (No. 166) both precipitated 55 and 60 kDa proteins that were of similar molecular weights as the standard. Staining patterns on the various cell types were similar. Both new antibodies inhibited the binding of the CD5a reference mAbs b53b7 to peripheral lymphocytes. These mAbs, therefore both react with the CD5a epitope bringing the number of anti-porcine CD5 mAbs to eight, all of which appear to recognize the same epitope. 2020-10-22T14:47:35Z 2020-10-22T14:47:35Z 1998 conference object http://hdl.handle.net/20.500.12792/3491 10.1016/S0165-2427(97)00103-7 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ open access
institution INIA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
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databasecode dig-inia-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del INIA España
language eng
description Among the 57 monoclonal antibodies analyzed within the T-cell group, three mAbs fell within cluster T13 including the CD5a standard b53b7 (No. 174). The two new mAbs 1H6/8 (No. 058) and BB6-9G12 (No. 166) both precipitated 55 and 60 kDa proteins that were of similar molecular weights as the standard. Staining patterns on the various cell types were similar. Both new antibodies inhibited the binding of the CD5a reference mAbs b53b7 to peripheral lymphocytes. These mAbs, therefore both react with the CD5a epitope bringing the number of anti-porcine CD5 mAbs to eight, all of which appear to recognize the same epitope.
format conference object
author Pescovitz, M. D.
Book, B. K.
Aasted, B.
Dominguez, J.
Bullido, R.
Trebichavsky, I.
Novikov, B.
Valpotic, I.
Tomaskovic, M.
Nielsen, J.
Arn, S.
Sachs, D. H.
Lunney, J. K.
Boyd, P. C.
Walker, J.
Lee, R.
Saalmüller, A.
spellingShingle Pescovitz, M. D.
Book, B. K.
Aasted, B.
Dominguez, J.
Bullido, R.
Trebichavsky, I.
Novikov, B.
Valpotic, I.
Tomaskovic, M.
Nielsen, J.
Arn, S.
Sachs, D. H.
Lunney, J. K.
Boyd, P. C.
Walker, J.
Lee, R.
Saalmüller, A.
Analyses of monoclonal antibodies reacting with porcine CD5 Results from the Second International Swine CD Workshop
author_facet Pescovitz, M. D.
Book, B. K.
Aasted, B.
Dominguez, J.
Bullido, R.
Trebichavsky, I.
Novikov, B.
Valpotic, I.
Tomaskovic, M.
Nielsen, J.
Arn, S.
Sachs, D. H.
Lunney, J. K.
Boyd, P. C.
Walker, J.
Lee, R.
Saalmüller, A.
author_sort Pescovitz, M. D.
title Analyses of monoclonal antibodies reacting with porcine CD5 Results from the Second International Swine CD Workshop
title_short Analyses of monoclonal antibodies reacting with porcine CD5 Results from the Second International Swine CD Workshop
title_full Analyses of monoclonal antibodies reacting with porcine CD5 Results from the Second International Swine CD Workshop
title_fullStr Analyses of monoclonal antibodies reacting with porcine CD5 Results from the Second International Swine CD Workshop
title_full_unstemmed Analyses of monoclonal antibodies reacting with porcine CD5 Results from the Second International Swine CD Workshop
title_sort analyses of monoclonal antibodies reacting with porcine cd5 results from the second international swine cd workshop
publishDate 1998
url http://hdl.handle.net/20.500.12792/3491
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