Ixodicidal compounds from pre-domesticated Lavandula luisieri

Several extracts from pre-domesticated Lavandula luisieri (Rozeira) Riv-Mart. (Lamiaceae) (essential oil, EO; hexane, Hx and the organic fraction of the residual hydrolate, WRO) showed larvicidal effects against the hard tick Hyalomma lusitanicum, being WRO the most active. Their content in the necrodane-type monoterpenes (2,2,3,4-tetramethyl-5-oxocyclopent-3-en-1-yl)-methyl acetate (2), 5-hydroxymethyl-2,3,4,4-tetramethylcyclopent-2-en-1-one (1) and 2-(hydroxymethyl)-3,4,4-trimethyl-5-methylenecyclopent-2-en-1-one (5) correlated with these effects. Among the isolated compounds, 3,3,4,5-tetramethyl-2H-pyran-2,6(3H)-dione (7) and (2,2,3,4-tetramethyl-5-oxocyclopent-3-en-1-yl)-methyl acetate (2) were the most potent ones, with activity levels within the range of the positive control thymol. These compounds represent a new class of ixodicidal agents. © 2017 Elsevier B.V.

Bibliographic Details

Main Authors:	Julio, L. F., Díaz, C. E., Aissani, N., Valcarcel, F., Burillo, J., Olmeda, S., González-Coloma, A.
Format:	journal article biblioteca
Language:	eng
Published:	2017
Online Access:	http://hdl.handle.net/20.500.12792/2240
Tags:	Add Tag No Tags, Be the first to tag this record!