The N-terminal region of the VP1 protein of swine vesicular disease virus contains a neutralization site that arises upon cell attachment and is involved in viral entry
The N-terminal region of VP1 of swine vesicular disease virus (SVDV) is highly antigenic in swine, despite its internal location in the capsid. Here we show that antibodies to this region can block infection and that allowing the virus to attach to cells increases this blockage significantly. The results indicate that upon binding to the cell, SVDV capsid undergoes a conformational change that is temperature independent and that exposes the N terminus of VP1. This process makes this region accessible to antibodies which block virus entry.
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | journal article biblioteca |
| Language: | eng |
| Published: |
2001
|
| Online Access: | http://hdl.handle.net/20.500.12792/2206 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
dig-inia-es-20.500.12792-2206 |
|---|---|
| record_format |
koha |
| spelling |
dig-inia-es-20.500.12792-22062020-12-15T09:52:35Z The N-terminal region of the VP1 protein of swine vesicular disease virus contains a neutralization site that arises upon cell attachment and is involved in viral entry Jiménez-Clavero, M. A. Escribano-Romero, E. Douglas, A. J. Ley, V. The N-terminal region of VP1 of swine vesicular disease virus (SVDV) is highly antigenic in swine, despite its internal location in the capsid. Here we show that antibodies to this region can block infection and that allowing the virus to attach to cells increases this blockage significantly. The results indicate that upon binding to the cell, SVDV capsid undergoes a conformational change that is temperature independent and that exposes the N terminus of VP1. This process makes this region accessible to antibodies which block virus entry. 2020-10-22T12:40:43Z 2020-10-22T12:40:43Z 2001 journal article http://hdl.handle.net/20.500.12792/2206 10.1128/JVI.75.2.1044-1047.2001 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ open access |
| institution |
INIA ES |
| collection |
DSpace |
| country |
España |
| countrycode |
ES |
| component |
Bibliográfico |
| access |
En linea |
| databasecode |
dig-inia-es |
| tag |
biblioteca |
| region |
Europa del Sur |
| libraryname |
Biblioteca del INIA España |
| language |
eng |
| description |
The N-terminal region of VP1 of swine vesicular disease virus (SVDV) is highly antigenic in swine, despite its internal location in the capsid. Here we show that antibodies to this region can block infection and that allowing the virus to attach to cells increases this blockage significantly. The results indicate that upon binding to the cell, SVDV capsid undergoes a conformational change that is temperature independent and that exposes the N terminus of VP1. This process makes this region accessible to antibodies which block virus entry. |
| format |
journal article |
| author |
Jiménez-Clavero, M. A. Escribano-Romero, E. Douglas, A. J. Ley, V. |
| spellingShingle |
Jiménez-Clavero, M. A. Escribano-Romero, E. Douglas, A. J. Ley, V. The N-terminal region of the VP1 protein of swine vesicular disease virus contains a neutralization site that arises upon cell attachment and is involved in viral entry |
| author_facet |
Jiménez-Clavero, M. A. Escribano-Romero, E. Douglas, A. J. Ley, V. |
| author_sort |
Jiménez-Clavero, M. A. |
| title |
The N-terminal region of the VP1 protein of swine vesicular disease virus contains a neutralization site that arises upon cell attachment and is involved in viral entry |
| title_short |
The N-terminal region of the VP1 protein of swine vesicular disease virus contains a neutralization site that arises upon cell attachment and is involved in viral entry |
| title_full |
The N-terminal region of the VP1 protein of swine vesicular disease virus contains a neutralization site that arises upon cell attachment and is involved in viral entry |
| title_fullStr |
The N-terminal region of the VP1 protein of swine vesicular disease virus contains a neutralization site that arises upon cell attachment and is involved in viral entry |
| title_full_unstemmed |
The N-terminal region of the VP1 protein of swine vesicular disease virus contains a neutralization site that arises upon cell attachment and is involved in viral entry |
| title_sort |
n-terminal region of the vp1 protein of swine vesicular disease virus contains a neutralization site that arises upon cell attachment and is involved in viral entry |
| publishDate |
2001 |
| url |
http://hdl.handle.net/20.500.12792/2206 |
| work_keys_str_mv |
AT jimenezclaveroma thenterminalregionofthevp1proteinofswinevesiculardiseaseviruscontainsaneutralizationsitethatarisesuponcellattachmentandisinvolvedinviralentry AT escribanoromeroe thenterminalregionofthevp1proteinofswinevesiculardiseaseviruscontainsaneutralizationsitethatarisesuponcellattachmentandisinvolvedinviralentry AT douglasaj thenterminalregionofthevp1proteinofswinevesiculardiseaseviruscontainsaneutralizationsitethatarisesuponcellattachmentandisinvolvedinviralentry AT leyv thenterminalregionofthevp1proteinofswinevesiculardiseaseviruscontainsaneutralizationsitethatarisesuponcellattachmentandisinvolvedinviralentry AT jimenezclaveroma nterminalregionofthevp1proteinofswinevesiculardiseaseviruscontainsaneutralizationsitethatarisesuponcellattachmentandisinvolvedinviralentry AT escribanoromeroe nterminalregionofthevp1proteinofswinevesiculardiseaseviruscontainsaneutralizationsitethatarisesuponcellattachmentandisinvolvedinviralentry AT douglasaj nterminalregionofthevp1proteinofswinevesiculardiseaseviruscontainsaneutralizationsitethatarisesuponcellattachmentandisinvolvedinviralentry AT leyv nterminalregionofthevp1proteinofswinevesiculardiseaseviruscontainsaneutralizationsitethatarisesuponcellattachmentandisinvolvedinviralentry |
| _version_ |
1758004777039429632 |