Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance
Patterns of leptin secretion during the estrous cycle and the possible relationship of changes in circulating leptin during the periovulatory period with ovarian function in sows of obese (Iberian breed) and lean genotype (Large White × Landrace) were evaluated in two consecutive experiments. Plasma leptin concentrations throughout the estrous cycle in lean sows remain unchanged, but Iberian females showed a periovulatory increase in circulating leptin levels without associated changes in body condition and fatness. In these sows, plasma leptin concentrations at Days -1 and 0 of the cycle were found to be positively correlated with the ovulation rate (r = 0.943 and r = 0.987, respectively; P < 0.05 for both), but the levels of leptin at Day 0 were negatively correlated with the progesterone release from Day 3 (r = -0.557; P < 0.05) and, became more evident at Day 5 of the estrous cycle (r = -0.924; P < 0.005). Such relationships were not observed in the females of the lean genotype. In conclusion, the present study indicates the existence of a distinctive pattern in the periovulatory leptin secretion in swine with obesity and leptin resistance, which is associated with the number and functionality of the corpora lutea present in the subsequent cycle. © 2012 Elsevier Inc.
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dig-inia-es-20.500.12792-18872020-12-15T09:48:02Z Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance Gonzalez-Bulnes, A. Astiz, S. Encinas, T. Gonzalez-Añover, P. Perez-Solana, M. Sanchez-Sanchez, R. Torres-Rovira, L. Tresguerres, J. A. F. Patterns of leptin secretion during the estrous cycle and the possible relationship of changes in circulating leptin during the periovulatory period with ovarian function in sows of obese (Iberian breed) and lean genotype (Large White × Landrace) were evaluated in two consecutive experiments. Plasma leptin concentrations throughout the estrous cycle in lean sows remain unchanged, but Iberian females showed a periovulatory increase in circulating leptin levels without associated changes in body condition and fatness. In these sows, plasma leptin concentrations at Days -1 and 0 of the cycle were found to be positively correlated with the ovulation rate (r = 0.943 and r = 0.987, respectively; P < 0.05 for both), but the levels of leptin at Day 0 were negatively correlated with the progesterone release from Day 3 (r = -0.557; P < 0.05) and, became more evident at Day 5 of the estrous cycle (r = -0.924; P < 0.005). Such relationships were not observed in the females of the lean genotype. In conclusion, the present study indicates the existence of a distinctive pattern in the periovulatory leptin secretion in swine with obesity and leptin resistance, which is associated with the number and functionality of the corpora lutea present in the subsequent cycle. © 2012 Elsevier Inc. 2020-10-22T12:18:39Z 2020-10-22T12:18:39Z 2012 journal article http://hdl.handle.net/20.500.12792/1887 10.1016/j.peptides.2012.07.016 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ open access |
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Patterns of leptin secretion during the estrous cycle and the possible relationship of changes in circulating leptin during the periovulatory period with ovarian function in sows of obese (Iberian breed) and lean genotype (Large White × Landrace) were evaluated in two consecutive experiments. Plasma leptin concentrations throughout the estrous cycle in lean sows remain unchanged, but Iberian females showed a periovulatory increase in circulating leptin levels without associated changes in body condition and fatness. In these sows, plasma leptin concentrations at Days -1 and 0 of the cycle were found to be positively correlated with the ovulation rate (r = 0.943 and r = 0.987, respectively; P < 0.05 for both), but the levels of leptin at Day 0 were negatively correlated with the progesterone release from Day 3 (r = -0.557; P < 0.05) and, became more evident at Day 5 of the estrous cycle (r = -0.924; P < 0.005). Such relationships were not observed in the females of the lean genotype. In conclusion, the present study indicates the existence of a distinctive pattern in the periovulatory leptin secretion in swine with obesity and leptin resistance, which is associated with the number and functionality of the corpora lutea present in the subsequent cycle. © 2012 Elsevier Inc. |
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author |
Gonzalez-Bulnes, A. Astiz, S. Encinas, T. Gonzalez-Añover, P. Perez-Solana, M. Sanchez-Sanchez, R. Torres-Rovira, L. Tresguerres, J. A. F. |
spellingShingle |
Gonzalez-Bulnes, A. Astiz, S. Encinas, T. Gonzalez-Añover, P. Perez-Solana, M. Sanchez-Sanchez, R. Torres-Rovira, L. Tresguerres, J. A. F. Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance |
author_facet |
Gonzalez-Bulnes, A. Astiz, S. Encinas, T. Gonzalez-Añover, P. Perez-Solana, M. Sanchez-Sanchez, R. Torres-Rovira, L. Tresguerres, J. A. F. |
author_sort |
Gonzalez-Bulnes, A. |
title |
Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance |
title_short |
Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance |
title_full |
Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance |
title_fullStr |
Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance |
title_full_unstemmed |
Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance |
title_sort |
characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance |
publishDate |
2012 |
url |
http://hdl.handle.net/20.500.12792/1887 |
work_keys_str_mv |
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