Virulence evolution of a sterilizing plant virus: Tuning multiplication and resource exploitation

Vijayan, Viji; López-González, Silvia; Sánchez, Flora; Ponz Ascaso, Fernando; Pagán, Israel; Ministerio de Economía y Competitividad (España)

Virulence evolution of a sterilizing plant virus: Tuning multiplication and resource exploitation

11 Pág.

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Main Authors:	Vijayan, Viji, López-González, Silvia, Sánchez, Flora, Ponz Ascaso, Fernando, Pagán, Israel
Other Authors:	Ministerio de Economía y Competitividad (España)
Format:	artículo biblioteca
Language:	English
Published:	Oxford University Press 2017-11-06
Subjects:	Arabidopsis thaliana, Turnip mosaic virus, Host resource exploitation, Virulence evolution,
Online Access:	http://hdl.handle.net/10261/363125 https://api.elsevier.com/content/abstract/scopus_id/85035765896
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spelling	dig-inia-es-10261-3631252024-07-09T20:43:56Z Virulence evolution of a sterilizing plant virus: Tuning multiplication and resource exploitation Vijayan, Viji López-González, Silvia Sánchez, Flora Ponz Ascaso, Fernando Pagán, Israel Ministerio de Economía y Competitividad (España) European Commission López-González, Silvia [0000-0001-7324-0310] Ponz Ascaso, Fernando [0000-0003-0344-4363] Pagán, Israel [0000-0001-8876-1194] Arabidopsis thaliana Turnip mosaic virus Host resource exploitation Virulence evolution 11 Pág. Virulence evolution may have far-reaching consequences for virus epidemiology and emergence, and virologists have devoted increasing effort to understand the modulators of this process. However, still little is known on the mechanisms and determinants of virulence evolution in sterilizing viruses that, as they prevent host reproduction, may have devastating effects on host populations. Theory predicts that sterilizing parasites, including viruses, would evolve towards lower virulence and absolute host sterilization to optimize the exploitation of host resources and maximize fitness. However, this hypothesis has seldom been analyzed experimentally. We investigated the evolution of virulence of the sterilizing plant virus Turnip mosaic virus (TuMV) in its natural host Arabidopsis thaliana by serial passage experiments. After passaging, we quantified virus accumulation and infectivity, the effect of infection on plant growth and development, and virulence of the ancestral and passaged viral genotypes in A. thaliana. Results indicated that serial passaging increased the proportion of infected plants showing absolute sterility, reduced TuMV virulence, and increased virus multiplication and infectivity. Genomic comparison of the ancestral and passaged TuMV genotypes identified significant mutation clustering in the P1, P3, and 6K2 proteins, suggesting a role of these viral proteins in the observed phenotypic changes. Our results support theoretical predictions on the evolution of virulence of sterilizing parasites and contribute to better understand the phenotypic and genetic changes associated with this process. This work was supported by a Ramón y Cajal grant from the Ministerio de Economía y Competitividad de España (RYC-2011-08574). V.V. was supported by an Erasmus Mundus BRAVE Scholarship of the EU (2013-2536/001-001). Peer reviewed 2024-07-09T06:56:24Z 2024-07-09T06:56:24Z 2017-11-06 artículo Virus Evolution 3(2): vex033 (2017) 2057-1577 http://hdl.handle.net/10261/363125 10.1093/ve/vex033 29250431 2-s2.0-85035765896 https://api.elsevier.com/content/abstract/scopus_id/85035765896 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MICINN//RYC-2011-08574/ES/RYC-2011-08574/ Centro de Biotecnología y Genómica de Plantas (CBGP) Publisher's version https://doi.org/10.1093/ve/vex033 Sí open application/pdf Oxford University Press
institution	INIA ES
collection	DSpace
country	España
countrycode	ES
component	Bibliográfico
access	En linea
databasecode	dig-inia-es
tag	biblioteca
region	Europa del Sur
libraryname	Biblioteca del INIA España
language	English
topic	Arabidopsis thaliana Turnip mosaic virus Host resource exploitation Virulence evolution Arabidopsis thaliana Turnip mosaic virus Host resource exploitation Virulence evolution
spellingShingle	Arabidopsis thaliana Turnip mosaic virus Host resource exploitation Virulence evolution Arabidopsis thaliana Turnip mosaic virus Host resource exploitation Virulence evolution Vijayan, Viji López-González, Silvia Sánchez, Flora Ponz Ascaso, Fernando Pagán, Israel Virulence evolution of a sterilizing plant virus: Tuning multiplication and resource exploitation
description	11 Pág.
author2	Ministerio de Economía y Competitividad (España)
author_facet	Ministerio de Economía y Competitividad (España) Vijayan, Viji López-González, Silvia Sánchez, Flora Ponz Ascaso, Fernando Pagán, Israel
format	artículo
topic_facet	Arabidopsis thaliana Turnip mosaic virus Host resource exploitation Virulence evolution
author	Vijayan, Viji López-González, Silvia Sánchez, Flora Ponz Ascaso, Fernando Pagán, Israel
author_sort	Vijayan, Viji
title	Virulence evolution of a sterilizing plant virus: Tuning multiplication and resource exploitation
title_short	Virulence evolution of a sterilizing plant virus: Tuning multiplication and resource exploitation
title_full	Virulence evolution of a sterilizing plant virus: Tuning multiplication and resource exploitation
title_fullStr	Virulence evolution of a sterilizing plant virus: Tuning multiplication and resource exploitation
title_full_unstemmed	Virulence evolution of a sterilizing plant virus: Tuning multiplication and resource exploitation
title_sort	virulence evolution of a sterilizing plant virus: tuning multiplication and resource exploitation
publisher	Oxford University Press
publishDate	2017-11-06
url	http://hdl.handle.net/10261/363125 https://api.elsevier.com/content/abstract/scopus_id/85035765896
work_keys_str_mv	AT vijayanviji virulenceevolutionofasterilizingplantvirustuningmultiplicationandresourceexploitation AT lopezgonzalezsilvia virulenceevolutionofasterilizingplantvirustuningmultiplicationandresourceexploitation AT sanchezflora virulenceevolutionofasterilizingplantvirustuningmultiplicationandresourceexploitation AT ponzascasofernando virulenceevolutionofasterilizingplantvirustuningmultiplicationandresourceexploitation AT paganisrael virulenceevolutionofasterilizingplantvirustuningmultiplicationandresourceexploitation
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Virulence evolution of a sterilizing plant virus: Tuning multiplication and resource exploitation

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