Between but Not Within-Species Variation in the Distribution of Fitness Effects
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| Format: | artículo biblioteca |
| Language: | English |
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Oxford University Press
2023-10-13
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| Subjects: | DFE, Deleterious mutations, Forest trees, Population structure, |
| Online Access: | http://hdl.handle.net/10261/349802 http://dx.doi.org/10.13039/501100006251 http://dx.doi.org/10.13039/100001388 http://dx.doi.org/10.13039/501100000780 https://api.elsevier.com/content/abstract/scopus_id/85176509592 |
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dig-inia-es-10261-3498022024-05-15T20:43:52Z Between but Not Within-Species Variation in the Distribution of Fitness Effects James, Jennifer Kastally, Chedly Budde, Katharina González-Martínez, Santiago C. Milesi, Pascal Pyhäjärvi, Tanja Lascoux, Martin GenTree Consortium Wenner-Gren Foundation European Commission Gouvernement de la République française Université de Bordeaux Swedish National Infrastructure for Computing Swedish Research Council James, Jennifer [0000-0003-0518-6783] Kastally, Chedly [0000-0002-1820-4752] Budde, Katharina [0000-0002-5361-2815] González-Martínez, Santiago C. [0000-0002-4534-3766] Milesi, Pascal [0000-0003-2907-564X] Pyhäjärvi, Tanja [0000-0001-6958-5172] Lascoux, Martin [0000-0003-1699-9042] DFE Deleterious mutations Forest trees Population structure 16 Pág. New mutations provide the raw material for evolution and adaptation. The distribution of fitness effects (DFE) describes the spectrum of effects of new mutations that can occur along a genome, and is, therefore, of vital interest in evolutionary biology. Recent work has uncovered striking similarities in the DFE between closely related species, prompting us to ask whether there is variation in the DFE among populations of the same species, or among species with different degrees of divergence, that is whether there is variation in the DFE at different levels of evolution. Using exome capture data from six tree species sampled across Europe we characterized the DFE for multiple species, and for each species, multiple populations, and investigated the factors potentially influencing the DFE, such as demography, population divergence, and genetic background. We find statistical support for the presence of variation in the DFE at the species level, even among relatively closely related species. However, we find very little difference at the population level, suggesting that differences in the DFE are primarily driven by deep features of species biology, and those evolutionarily recent events, such as demographic changes and local adaptation, have little impact. J.J. was supported by a grant from the Wenner-Gren Foundation. The present project was supported by the European Union's Horizon 2020 Research and Innovation Programme grant agreement no. 676876 (Gentree). S.C.G.-M. was supported by the French government in the framework of the IdEX Bordeaux University “Investments for the Future” programme/GPR Bordeaux Plant Sciences. The computations were enabled by resources in project SNIC 2022/22-910 provided by the Swedish National Infrastructure for Computing (SNIC) at UPPMAX, partially funded by the Swedish Research Council (VR) through grant agreement no. 2018-05973. We are grateful to Sylvain Glémin for his input on an earlier draft of this manuscript, and to two anonymous reviewers for their valuable insights into this work. Peer reviewed 2024-03-08T13:18:17Z 2024-03-08T13:18:17Z 2023-10-13 artículo http://purl.org/coar/resource_type/c_6501 Molecular Biology and Evolution 40(11): msad228 (2023) 0737-4038 http://hdl.handle.net/10261/349802 10.1093/molbev/msad228 1537-1719 http://dx.doi.org/10.13039/501100006251 http://dx.doi.org/10.13039/100001388 http://dx.doi.org/10.13039/501100000780 37832225 2-s2.0-85176509592 https://api.elsevier.com/content/abstract/scopus_id/85176509592 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/H2020/676876 Instituto de Ciencias Forestales (ICIFOR) Publisher's version https://doi.org/10.1093/molbev/msad228 Sí open application/pdf Oxford University Press |
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DFE Deleterious mutations Forest trees Population structure DFE Deleterious mutations Forest trees Population structure |
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DFE Deleterious mutations Forest trees Population structure DFE Deleterious mutations Forest trees Population structure James, Jennifer Kastally, Chedly Budde, Katharina González-Martínez, Santiago C. Milesi, Pascal Pyhäjärvi, Tanja Lascoux, Martin GenTree Consortium Between but Not Within-Species Variation in the Distribution of Fitness Effects |
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16 Pág. |
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Wenner-Gren Foundation |
| author_facet |
Wenner-Gren Foundation James, Jennifer Kastally, Chedly Budde, Katharina González-Martínez, Santiago C. Milesi, Pascal Pyhäjärvi, Tanja Lascoux, Martin GenTree Consortium |
| format |
artículo |
| topic_facet |
DFE Deleterious mutations Forest trees Population structure |
| author |
James, Jennifer Kastally, Chedly Budde, Katharina González-Martínez, Santiago C. Milesi, Pascal Pyhäjärvi, Tanja Lascoux, Martin GenTree Consortium |
| author_sort |
James, Jennifer |
| title |
Between but Not Within-Species Variation in the Distribution of Fitness Effects |
| title_short |
Between but Not Within-Species Variation in the Distribution of Fitness Effects |
| title_full |
Between but Not Within-Species Variation in the Distribution of Fitness Effects |
| title_fullStr |
Between but Not Within-Species Variation in the Distribution of Fitness Effects |
| title_full_unstemmed |
Between but Not Within-Species Variation in the Distribution of Fitness Effects |
| title_sort |
between but not within-species variation in the distribution of fitness effects |
| publisher |
Oxford University Press |
| publishDate |
2023-10-13 |
| url |
http://hdl.handle.net/10261/349802 http://dx.doi.org/10.13039/501100006251 http://dx.doi.org/10.13039/100001388 http://dx.doi.org/10.13039/501100000780 https://api.elsevier.com/content/abstract/scopus_id/85176509592 |
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