Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)

Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)

9 Pág.

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Main Authors: Porras, Néstor, Chinchilla, B., Rodríguez-Bertos, A., Barasona, Jose A., Kosowska, Aleksandra, Vázquez-Fernández, E., Sánchez-Cordón, P. J., Sánchez-Vizcaíno, J. M.
Other Authors: European Commission
Format: artículo biblioteca
Language:English
Published: Frontiers Media 2023-12-12
Subjects:African swine fever virus (ASFV), Highly virulent isolate, Histopathology, Immunohistochemistry, Intrapancreatic accessory spleen (IPAS), Low virulence isolate, Wild boar,
Online Access:http://hdl.handle.net/10261/349300
http://dx.doi.org/10.13039/501100000780
https://api.elsevier.com/content/abstract/scopus_id/85180717630
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spelling dig-inia-es-10261-3493002024-05-18T20:41:26Z Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa) Porras, Néstor Chinchilla, B. Rodríguez-Bertos, A. Barasona, Jose A. Kosowska, Aleksandra Vázquez-Fernández, E. Sánchez-Cordón, P. J. Sánchez-Vizcaíno, J. M. European Commission Porras, Néstor [0000-0002-2876-8850] Chinchilla, B. [0000-0002-0679-9023] Rodríguez-Bertos, A. [0000-0001-9543-313X] Barasona, Jose A. [0000-0003-4066-8454] Kosowska, Aleksandra [0000-0002-0016-8765] Vázquez-Fernández, E. [0000-0002-1510-5329] Sánchez-Cordón, P. J. [0000-0002-7202-6475] Sánchez-Vizcaíno, J. M. [0000-0002-1502-8968] African swine fever virus (ASFV) Highly virulent isolate Histopathology Immunohistochemistry Intrapancreatic accessory spleen (IPAS) Low virulence isolate Wild boar 9 Pág. Intrapancreatic accessory spleen (IPAS) is one of the most frequent congenital splenic anomalies in humans; however, studies in veterinary medicine are scarce. This study aimed to describe the macroscopic, histopathological and immunohistochemical features of 11 suspected cases of IPAS in wild boar piglets of 3-4 months old. Seven of the 11 animals were immunised with a low virulence isolate of African swine fever virus (ASFV) and subsequently challenged with a highly virulent ASFV isolate (LVI-HVI group). The remaining four animals were exclusively infected with a highly virulent isolate of ASFV (HVI group). Grossly, lesions comprised focal or multifocal reddish areas of variable shape, located on the surface of the pancreatic tail or within the parenchyma. Histological and immunohistochemical studies (anti-CD79 and CD3) confirmed the presence of IPAS in eight of the 11 cases. IPAS shared the same histological structure and alterations as those observed in the original spleen. The immunohistochemical study against ASFV revealed the presence of VP72+ cells in both the spleen and IPAS of seven of the eight piglets. The results of this study describe for the first time the presence of IPAS in ASFV infection of wild boar (Sus scrofa) regardless the isolate and suggest that the infection may induce the development of ectopic splenic tissue due to an increased demand for phagocytic cells from the reticuloendothelial system. However, further studies are needed to understand the immunological mechanisms that trigger the formation of these accessory organs. The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was funded by European Project H2020 VACDIVA – “A Safe DIVA vaccine for African Swine Fever control and eradication,” grant agreement n° 862874. Peer reviewed 2024-03-05T11:53:44Z 2024-03-05T11:53:44Z 2023-12-12 artículo http://purl.org/coar/resource_type/c_6501 Frontiers in Veterinary Science 10: e1306320 (2023) http://hdl.handle.net/10261/349300 10.3389/fvets.2023.1306320 2297-1769 http://dx.doi.org/10.13039/501100000780 38155760 2-s2.0-85180717630 https://api.elsevier.com/content/abstract/scopus_id/85180717630 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/H2020/862874 Centro de Investigación en Sanidad Animal (CISA) Publisher's version https://doi.org/10.3389/fvets.2023.1306320 Sí open application/pdf Frontiers Media
institution INIA ES
collection DSpace
country España
countrycode ES
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databasecode dig-inia-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del INIA España
language English
topic African swine fever virus (ASFV)
Highly virulent isolate
Histopathology
Immunohistochemistry
Intrapancreatic accessory spleen (IPAS)
Low virulence isolate
Wild boar
African swine fever virus (ASFV)
Highly virulent isolate
Histopathology
Immunohistochemistry
Intrapancreatic accessory spleen (IPAS)
Low virulence isolate
Wild boar
spellingShingle African swine fever virus (ASFV)
Highly virulent isolate
Histopathology
Immunohistochemistry
Intrapancreatic accessory spleen (IPAS)
Low virulence isolate
Wild boar
African swine fever virus (ASFV)
Highly virulent isolate
Histopathology
Immunohistochemistry
Intrapancreatic accessory spleen (IPAS)
Low virulence isolate
Wild boar
Porras, Néstor
Chinchilla, B.
Rodríguez-Bertos, A.
Barasona, Jose A.
Kosowska, Aleksandra
Vázquez-Fernández, E.
Sánchez-Cordón, P. J.
Sánchez-Vizcaíno, J. M.
Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)
description 9 Pág.
author2 European Commission
author_facet European Commission
Porras, Néstor
Chinchilla, B.
Rodríguez-Bertos, A.
Barasona, Jose A.
Kosowska, Aleksandra
Vázquez-Fernández, E.
Sánchez-Cordón, P. J.
Sánchez-Vizcaíno, J. M.
format artículo
topic_facet African swine fever virus (ASFV)
Highly virulent isolate
Histopathology
Immunohistochemistry
Intrapancreatic accessory spleen (IPAS)
Low virulence isolate
Wild boar
author Porras, Néstor
Chinchilla, B.
Rodríguez-Bertos, A.
Barasona, Jose A.
Kosowska, Aleksandra
Vázquez-Fernández, E.
Sánchez-Cordón, P. J.
Sánchez-Vizcaíno, J. M.
author_sort Porras, Néstor
title Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)
title_short Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)
title_full Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)
title_fullStr Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)
title_full_unstemmed Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)
title_sort intrapancreatic accessory spleens in african swine fever infection of wild boar (sus scrofa)
publisher Frontiers Media
publishDate 2023-12-12
url http://hdl.handle.net/10261/349300
http://dx.doi.org/10.13039/501100000780
https://api.elsevier.com/content/abstract/scopus_id/85180717630
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