Expression of Siglec-1, -3, -5 and -10 in porcine cDC1 and cDC2 subsets from blood, spleen and lymph nodes and functional capabilities of these cells

Expression of Siglec-1, -3, -5 and -10 in porcine cDC1 and cDC2 subsets from blood, spleen and lymph nodes and functional capabilities of these cells

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Main Authors: Poderoso, Teresa, Martínez De la Riva, Paloma, Álvarez, Belén, Nieto-Pelegrín, E., Ezquerra Martínez, Ángel, Domínguez, Javier, Revilla Calvo, Concepción
Other Authors: CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)
Format: artículo biblioteca
Language:English
Published: Elsevier 2020-08
Subjects:Functional capabilities, Siglecs, Swine, cDC1, cDC2,
Online Access:http://hdl.handle.net/10261/339462
https://api.elsevier.com/content/abstract/scopus_id/85082657737
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spelling dig-inia-es-10261-3394622024-05-14T20:40:46Z Expression of Siglec-1, -3, -5 and -10 in porcine cDC1 and cDC2 subsets from blood, spleen and lymph nodes and functional capabilities of these cells Poderoso, Teresa Martínez De la Riva, Paloma Álvarez, Belén Nieto-Pelegrín, E. Ezquerra Martínez, Ángel Domínguez, Javier Revilla Calvo, Concepción CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) Poderoso, Teresa [0000-0002-1406-000X] Martínez De la Riva, Paloma [0000-0003-3097-022X] Álvarez, Belén [0000-0003-0426-0179] Nieto-Pelegrín, E. [0000-0003-2755-2641] Ezquerra Martínez, Ángel [0000-0002-1824-5087] Domínguez, Javier [0000-0001-7256-388X] Revilla Calvo, Concepción [0000-0002-8197-4186] Functional capabilities Siglecs Swine cDC1 cDC2 8 Pág. Dendritic cells are professional antigen-presenting cells that play a critical role in the development of immune responses. DCs express a variety of Siglecs on their surface, which play a regulatory role modulating their activation through interaction with sialylated structures expressed by cells or pathogens. Here, we characterized the phenotype of porcine conventional dendritic cells subsets from blood, spleen and lymph nodes, emphasizing the analysis of the expression of Siglecs. Siglec-1 was detected in type 1 cDC and, at lower levels, in type 2 cDC in the spleen, being low to negative in blood and lymph node cDC. Siglec-3 and Siglec-5 were expressed in cDC1 at lower levels than in cDC2. Porcine cDCs did not express Siglec-10. cDC2 showed a higher capacity to phagocytose microspheres and to process DQ™-OVA than cDC1, but none of these functions was affected by engagement of Siglec-3 and -5 with antibodies on blood cDC. This work was supported by grant RTA2014-00003-00-00 from INIA. Peer reviewed 2023-11-23T08:13:57Z 2023-11-23T08:13:57Z 2020-08 artículo http://purl.org/coar/resource_type/c_6501 Developmental and Comparative Immunology 109: e103692 (2020) 0145-305X http://hdl.handle.net/10261/339462 10.1016/j.dci.2020.103692 32234314 2-s2.0-85082657737 https://api.elsevier.com/content/abstract/scopus_id/85082657737 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO//RTA2014-00003-00-00/ES/Estudio fenotípico y funcional de las células dendríticas y de los macrófagos porcinos mediante la generación de anticuerpos monoclonales frente a los receptores XCR1 y CD200R/ Departamento de Biotecnología Publisher's version https://doi.org/10.1016/j.dci.2020.103692 Sí open Elsevier
institution INIA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-inia-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del INIA España
language English
topic Functional capabilities
Siglecs
Swine
cDC1
cDC2
Functional capabilities
Siglecs
Swine
cDC1
cDC2
spellingShingle Functional capabilities
Siglecs
Swine
cDC1
cDC2
Functional capabilities
Siglecs
Swine
cDC1
cDC2
Poderoso, Teresa
Martínez De la Riva, Paloma
Álvarez, Belén
Nieto-Pelegrín, E.
Ezquerra Martínez, Ángel
Domínguez, Javier
Revilla Calvo, Concepción
Expression of Siglec-1, -3, -5 and -10 in porcine cDC1 and cDC2 subsets from blood, spleen and lymph nodes and functional capabilities of these cells
description 8 Pág.
author2 CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)
author_facet CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)
Poderoso, Teresa
Martínez De la Riva, Paloma
Álvarez, Belén
Nieto-Pelegrín, E.
Ezquerra Martínez, Ángel
Domínguez, Javier
Revilla Calvo, Concepción
format artículo
topic_facet Functional capabilities
Siglecs
Swine
cDC1
cDC2
author Poderoso, Teresa
Martínez De la Riva, Paloma
Álvarez, Belén
Nieto-Pelegrín, E.
Ezquerra Martínez, Ángel
Domínguez, Javier
Revilla Calvo, Concepción
author_sort Poderoso, Teresa
title Expression of Siglec-1, -3, -5 and -10 in porcine cDC1 and cDC2 subsets from blood, spleen and lymph nodes and functional capabilities of these cells
title_short Expression of Siglec-1, -3, -5 and -10 in porcine cDC1 and cDC2 subsets from blood, spleen and lymph nodes and functional capabilities of these cells
title_full Expression of Siglec-1, -3, -5 and -10 in porcine cDC1 and cDC2 subsets from blood, spleen and lymph nodes and functional capabilities of these cells
title_fullStr Expression of Siglec-1, -3, -5 and -10 in porcine cDC1 and cDC2 subsets from blood, spleen and lymph nodes and functional capabilities of these cells
title_full_unstemmed Expression of Siglec-1, -3, -5 and -10 in porcine cDC1 and cDC2 subsets from blood, spleen and lymph nodes and functional capabilities of these cells
title_sort expression of siglec-1, -3, -5 and -10 in porcine cdc1 and cdc2 subsets from blood, spleen and lymph nodes and functional capabilities of these cells
publisher Elsevier
publishDate 2020-08
url http://hdl.handle.net/10261/339462
https://api.elsevier.com/content/abstract/scopus_id/85082657737
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