Inhibition of Orbivirus Replication by Aurintricarboxylic Acid

Inhibition of Orbivirus Replication by Aurintricarboxylic Acid

14 Pág.

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Main Authors: Alonso, Celia, Utrilla-Trigo, S., Calvo Pinilla, Eva María, Jiménez-Cabello, L., Ortego, Javier, Nogales, Aitor
Other Authors: European Commission
Format: artículo biblioteca
Language:English
Published: Multidisciplinary Digital Publishing Institute 2020-10-02
Subjects:Orbivirus, Arbovirus, Bluetongue virus, African horse sickness virus, Aurintricarboxylic acid, Antiviral,
Online Access:http://hdl.handle.net/10261/338236
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100000780
https://api.elsevier.com/content/abstract/scopus_id/85091939868
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spelling dig-inia-es-10261-3382362024-05-14T20:49:21Z Inhibition of Orbivirus Replication by Aurintricarboxylic Acid Alonso, Celia Utrilla-Trigo, S. Calvo Pinilla, Eva María Jiménez-Cabello, L. Ortego, Javier Nogales, Aitor European Commission Ministerio de Economía y Competitividad (España) CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) Utrilla-Trigo, S. [0000-0002-7672-7658] Calvo Pinilla, Eva María [0000-0002-4667-4081] Jiménez-Cabello, L. [0000-0001-8085-5823] Ortego, Javier [0000-0002-4275-7277] Nogales, Aitor [0000-0002-2424-7900] Orbivirus Arbovirus Bluetongue virus African horse sickness virus Aurintricarboxylic acid Antiviral 14 Pág. Bluetongue virus (BTV) and African horse sickness virus (AHSV) are vector-borne viruses belonging to the Orbivirus genus, which are transmitted between hosts primarily by biting midges of the genus Culicoides. With recent BTV and AHSV outbreaks causing epidemics and important economy losses, there is a pressing need for efficacious drugs to treat and control the spread of these infections. The polyanionic aromatic compound aurintricarboxylic acid (ATA) has been shown to have a broad-spectrum antiviral activity. Here, we evaluated ATA as a potential antiviral compound against Orbivirus infections in both mammalian and insect cells. Notably, ATA was able to prevent the replication of BTV and AHSV in both cell types in a time- and concentration-dependent manner. In addition, we evaluated the effect of ATA in vivo using a mouse model of infection. ATA did not protect mice against a lethal challenge with BTV or AHSV, most probably due to the in vivo effect of ATA on immune system regulation. Overall, these results demonstrate that ATA has inhibitory activity against Orbivirus replication in vitro, but further in vivo analysis will be required before considering it as a potential therapy for future clinical evaluation. This work was supported by the EU Horizon 2020 Program (European Commission grant agreement no. 727393-PALE-Blu [to J.O.]) and the Spanish Ministry of Economy and Competitiveness (MINECO) grant AGL2014-57430-R (to J.O. and A.N.). A.N. is supported by a MINECO “Ramon y Cajal” Incorporación grant (RYC-2017). S.U-T. is supported by an INIA SGIT-FPI predoctoral fellowship. Peer reviewed 2023-11-03T09:32:40Z 2023-11-03T09:32:40Z 2020-10-02 artículo http://purl.org/coar/resource_type/c_6501 International Journal of Molecular Sciences 21(19): 1-15 (2020) 1661-6596 http://hdl.handle.net/10261/338236 10.3390/ijms21197294 1422-0067 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100000780 33023235 2-s2.0-85091939868 https://api.elsevier.com/content/abstract/scopus_id/85091939868 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/H2020/727393 info:eu-repo/grantAgreement/MINECO//AGL2014-57430-R/ES/MEJORA Y EVALUACION DE VACUNAS BASADAS EN VECTORES VIRICOS Y MICROPARTICULAS FRENTE A ORBIVIRUS Y BUNYAVIRUS TRANSMITIDOS POR ARTROPODOS: HACIA EL DESARROLLO DE VACUNAS MULTIV/ info:eu-repo/grantAgreement/INIA-SGIT-FPI//RYC-2017 Centro de Investigación en Sanidad Animal (CISA) Publisher's version https://doi.org/10.3390/ijms21197294 Sí open application/pdf Multidisciplinary Digital Publishing Institute
institution INIA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-inia-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del INIA España
language English
topic Orbivirus
Arbovirus
Bluetongue virus
African horse sickness virus
Aurintricarboxylic acid
Antiviral
Orbivirus
Arbovirus
Bluetongue virus
African horse sickness virus
Aurintricarboxylic acid
Antiviral
spellingShingle Orbivirus
Arbovirus
Bluetongue virus
African horse sickness virus
Aurintricarboxylic acid
Antiviral
Orbivirus
Arbovirus
Bluetongue virus
African horse sickness virus
Aurintricarboxylic acid
Antiviral
Alonso, Celia
Utrilla-Trigo, S.
Calvo Pinilla, Eva María
Jiménez-Cabello, L.
Ortego, Javier
Nogales, Aitor
Inhibition of Orbivirus Replication by Aurintricarboxylic Acid
description 14 Pág.
author2 European Commission
author_facet European Commission
Alonso, Celia
Utrilla-Trigo, S.
Calvo Pinilla, Eva María
Jiménez-Cabello, L.
Ortego, Javier
Nogales, Aitor
format artículo
topic_facet Orbivirus
Arbovirus
Bluetongue virus
African horse sickness virus
Aurintricarboxylic acid
Antiviral
author Alonso, Celia
Utrilla-Trigo, S.
Calvo Pinilla, Eva María
Jiménez-Cabello, L.
Ortego, Javier
Nogales, Aitor
author_sort Alonso, Celia
title Inhibition of Orbivirus Replication by Aurintricarboxylic Acid
title_short Inhibition of Orbivirus Replication by Aurintricarboxylic Acid
title_full Inhibition of Orbivirus Replication by Aurintricarboxylic Acid
title_fullStr Inhibition of Orbivirus Replication by Aurintricarboxylic Acid
title_full_unstemmed Inhibition of Orbivirus Replication by Aurintricarboxylic Acid
title_sort inhibition of orbivirus replication by aurintricarboxylic acid
publisher Multidisciplinary Digital Publishing Institute
publishDate 2020-10-02
url http://hdl.handle.net/10261/338236
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100000780
https://api.elsevier.com/content/abstract/scopus_id/85091939868
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AT calvopinillaevamaria inhibitionoforbivirusreplicationbyaurintricarboxylicacid
AT jimenezcabellol inhibitionoforbivirusreplicationbyaurintricarboxylicacid
AT ortegojavier inhibitionoforbivirusreplicationbyaurintricarboxylicacid
AT nogalesaitor inhibitionoforbivirusreplicationbyaurintricarboxylicacid
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