African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update

African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update

34 Pág.

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Main Authors: Franzoni, Giulia, Pedrera, Miriam, Sánchez-Cordón, P. J.
Other Authors: Ministero della Salute
Format: artículo de revisión biblioteca
Language:English
Published: Multidisciplinary Digital Publishing Institute 2023-01-14
Subjects:African swine fever, Chemokines, Cytokines, Interferons, Interleukins,
Online Access:http://hdl.handle.net/10261/308255
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003196
https://api.elsevier.com/content/abstract/scopus_id/85147046402
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spelling dig-inia-es-10261-3082552024-10-26T20:48:37Z African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update Franzoni, Giulia Pedrera, Miriam Sánchez-Cordón, P. J. Ministero della Salute European Commission Franzoni, Giulia [0000-0003-0987-3863] Pedrera, Miriam [0000-0003-4868-6630] Sánchez-Cordón, P. J. [0000-0002-7202-6475] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] African swine fever Chemokines Cytokines Interferons Interleukins 34 Pág. African swine fever (ASF) is a hemorrhagic viral disease of domestic pigs and wild suids (all Sus scrofa) caused by the ASF virus (ASFV). The disease is spreading worldwide without control, threatening pig production due to the absence of licensed vaccine or commercially available treatments. A thorough understanding of the immunopathogenic mechanisms behind ASFV infection is required to better fight the disease. Cytokines are small, non-structural proteins, which play a crucial role in many aspects of the immune responses to viruses, including ASFV. Infection with virulent ASFV isolates often results in exacerbated immune responses, with increased levels of serum pro-inflammatory interleukins (IL-1α, IL-1β, IL-6), TNF and chemokines (CCL2, CCL5, CXCL10). Increased levels of IL-1, IL-6 and TNF are often detected in several tissues during acute ASFV infections and associated with lymphoid depletion, hemorrhages and oedemas. IL-1Ra is frequently released during ASFV infection to block further IL-1 activity, with its implication in ASFV immunopathology having been suggested. Increased levels of IFN-α and of the anti-inflammatory IL-10 seem to be negatively correlated with animal survival, whereas some correlation between virus-specific IFN-γ-producing cells and protection has been suggested in different studies where different vaccine candidates were tested, although future works should elucidate whether IFN-γ release by specific cell types is related to protection or disease development. Authors would like to thank the Italian Ministry of Health (grant IZS SA 06/21) for funding. Authors would like to thank the support received from the European project VACDIVA (EU-H2020-862874). Peer reviewed 2023-05-05T07:16:01Z 2023-05-05T07:16:01Z 2023-01-14 artículo de revisión http://purl.org/coar/resource_type/c_dcae04bc Viruses 15(1): e233 (2023) http://hdl.handle.net/10261/308255 10.3390/v15010233 1999-4915 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003196 36680273 2-s2.0-85147046402 https://api.elsevier.com/content/abstract/scopus_id/85147046402 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/H2020/862874 Centro de Investigación en Sanidad Animal (CISA) Publisher's version https://doi.org/10.3390/v15010233 Sí open Multidisciplinary Digital Publishing Institute
institution INIA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-inia-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del INIA España
language English
topic African swine fever
Chemokines
Cytokines
Interferons
Interleukins
African swine fever
Chemokines
Cytokines
Interferons
Interleukins
spellingShingle African swine fever
Chemokines
Cytokines
Interferons
Interleukins
African swine fever
Chemokines
Cytokines
Interferons
Interleukins
Franzoni, Giulia
Pedrera, Miriam
Sánchez-Cordón, P. J.
African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update
description 34 Pág.
author2 Ministero della Salute
author_facet Ministero della Salute
Franzoni, Giulia
Pedrera, Miriam
Sánchez-Cordón, P. J.
format artículo de revisión
topic_facet African swine fever
Chemokines
Cytokines
Interferons
Interleukins
author Franzoni, Giulia
Pedrera, Miriam
Sánchez-Cordón, P. J.
author_sort Franzoni, Giulia
title African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update
title_short African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update
title_full African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update
title_fullStr African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update
title_full_unstemmed African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update
title_sort african swine fever virus infection and cytokine response in vivo: an update
publisher Multidisciplinary Digital Publishing Institute
publishDate 2023-01-14
url http://hdl.handle.net/10261/308255
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003196
https://api.elsevier.com/content/abstract/scopus_id/85147046402
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AT pedreramiriam africanswinefevervirusinfectionandcytokineresponseinvivoanupdate
AT sanchezcordonpj africanswinefevervirusinfectionandcytokineresponseinvivoanupdate
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