Nanoparticle- and Microparticle-Based Vaccines against Orbiviruses of Veterinary Importance

Jiménez-Cabello, L.; Utrilla-Trigo, S.; Barreiro-Piñeiro, Natalia; Pose-Boirazian, Tomás; Martínez-Costas, José Manuel; Marín-López, A.; Ortego, Javier; Ministerio de Ciencia e Innovación (España)

Nanoparticle- and Microparticle-Based Vaccines against Orbiviruses of Veterinary Importance

27 Pág. Centro de Investigación en Sanidad Animal (CISA)

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Bibliographic Details
Main Authors:	Jiménez-Cabello, L., Utrilla-Trigo, S., Barreiro-Piñeiro, Natalia, Pose-Boirazian, Tomás, Martínez-Costas, José Manuel, Marín-López, A., Ortego, Javier
Other Authors:	Ministerio de Ciencia e Innovación (España)
Format:	artículo biblioteca
Language:	English
Published:	Multidisciplinary Digital Publishing Institute 2022-07-14
Subjects:	African horse sickness, Bluetongue, Epizootic hemorrhagic disease, Microcarrier, Nanocarriers, Orbivirus, Reovirus, Subunit vaccine,
Online Access:	http://hdl.handle.net/10261/296271 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100010801 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100004587 https://api.elsevier.com/content/abstract/scopus_id/85137293155
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region	Europa del Sur
libraryname	Biblioteca del INIA España
language	English
topic	African horse sickness Bluetongue Epizootic hemorrhagic disease Microcarrier Nanocarriers Orbivirus Reovirus Subunit vaccine African horse sickness Bluetongue Epizootic hemorrhagic disease Microcarrier Nanocarriers Orbivirus Reovirus Subunit vaccine
spellingShingle	African horse sickness Bluetongue Epizootic hemorrhagic disease Microcarrier Nanocarriers Orbivirus Reovirus Subunit vaccine African horse sickness Bluetongue Epizootic hemorrhagic disease Microcarrier Nanocarriers Orbivirus Reovirus Subunit vaccine Jiménez-Cabello, L. Utrilla-Trigo, S. Barreiro-Piñeiro, Natalia Pose-Boirazian, Tomás Martínez-Costas, José Manuel Marín-López, A. Ortego, Javier Nanoparticle- and Microparticle-Based Vaccines against Orbiviruses of Veterinary Importance
description	27 Pág. Centro de Investigación en Sanidad Animal (CISA)
author2	Ministerio de Ciencia e Innovación (España)
author_facet	Ministerio de Ciencia e Innovación (España) Jiménez-Cabello, L. Utrilla-Trigo, S. Barreiro-Piñeiro, Natalia Pose-Boirazian, Tomás Martínez-Costas, José Manuel Marín-López, A. Ortego, Javier
format	artículo
topic_facet	African horse sickness Bluetongue Epizootic hemorrhagic disease Microcarrier Nanocarriers Orbivirus Reovirus Subunit vaccine
author	Jiménez-Cabello, L. Utrilla-Trigo, S. Barreiro-Piñeiro, Natalia Pose-Boirazian, Tomás Martínez-Costas, José Manuel Marín-López, A. Ortego, Javier
author_sort	Jiménez-Cabello, L.
title	Nanoparticle- and Microparticle-Based Vaccines against Orbiviruses of Veterinary Importance
title_short	Nanoparticle- and Microparticle-Based Vaccines against Orbiviruses of Veterinary Importance
title_full	Nanoparticle- and Microparticle-Based Vaccines against Orbiviruses of Veterinary Importance
title_fullStr	Nanoparticle- and Microparticle-Based Vaccines against Orbiviruses of Veterinary Importance
title_full_unstemmed	Nanoparticle- and Microparticle-Based Vaccines against Orbiviruses of Veterinary Importance
title_sort	nanoparticle- and microparticle-based vaccines against orbiviruses of veterinary importance
publisher	Multidisciplinary Digital Publishing Institute
publishDate	2022-07-14
url	http://hdl.handle.net/10261/296271 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100010801 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100004587 https://api.elsevier.com/content/abstract/scopus_id/85137293155
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spelling	dig-inia-es-10261-2962712024-05-14T20:46:41Z Nanoparticle- and Microparticle-Based Vaccines against Orbiviruses of Veterinary Importance Jiménez-Cabello, L. Utrilla-Trigo, S. Barreiro-Piñeiro, Natalia Pose-Boirazian, Tomás Martínez-Costas, José Manuel Marín-López, A. Ortego, Javier Ministerio de Ciencia e Innovación (España) Instituto de Salud Carlos III Xunta de Galicia European Commission CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) Jiménez-Cabello, L. [0000-0001-8085-5823] Utrilla-Trigo, S. [0000-0002-7672-7658] Barreiro-Piñeiro, Natalia [0000-0001-8822-7709] Pose-Boirazian, Tomás [0000-0002-7958-9852] Martínez-Costas, José Manuel [0000-0002-8877-7775] Marín-López, A. [0000-0003-2840-1722] Ortego, Javier [0000-0002-4275-7277] African horse sickness Bluetongue Epizootic hemorrhagic disease Microcarrier Nanocarriers Orbivirus Reovirus Subunit vaccine 27 Pág. Centro de Investigación en Sanidad Animal (CISA) Bluetongue virus (BTV) and African horse sickness virus (AHSV) are widespread arboviruses that cause important economic losses in the livestock and equine industries, respectively. In addition to these, another arthropod-transmitted orbivirus known as epizootic hemorrhagic disease virus (EHDV) entails a major threat as there is a conducive landscape that nurtures its emergence in non-endemic countries. To date, only vaccinations with live attenuated or inactivated vaccines permit the control of these three viral diseases, although important drawbacks, e.g., low safety profile and effectiveness, and lack of DIVA (differentiation of infected from vaccinated animals) properties, constrain their usage as prophylactic measures. Moreover, a substantial number of serotypes of BTV, AHSV and EHDV have been described, with poor induction of cross-protective immune responses among serotypes. In the context of next-generation vaccine development, antigen delivery systems based on nano- or microparticles have gathered significant attention during the last few decades. A diversity of technologies, such as virus-like particles or self-assembled protein complexes, have been implemented for vaccine design against these viruses. In this work, we offer a comprehensive review of the nano- and microparticulated vaccine candidates against these three relevant orbiviruses. Additionally, we also review an innovative technology for antigen delivery based on the avian reovirus nonstructural protein muNS and we explore the prospective functionality of the nonstructural protein NS1 nanotubules as a BTV-based delivery platform. This research was funded by grants PID2020-112992RR-I00 and PID2019-105308RB-I00 from the Spanish Ministry of Science, / from ISCIII and DEVASARMIC from Santander-CRUE. The Xunta de Galicia (ED431B 2018/04, Centro singular de investigación de Galicia accreditation 2016–2019) and the European Union (European Regional Development Fund - ERDF) are gratefully acknowledged. S.U-T. was a recipient of a predoctoral fellowship from the Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Centro de Investigación en Sanidad Animal (program FPI-SGIT-2018). Peer reviewed 2023-03-01T08:33:26Z 2023-03-01T08:33:26Z 2022-07-14 artículo http://purl.org/coar/resource_type/c_6501 Vaccines10(7): e1124 (2022) 2076-393X http://hdl.handle.net/10261/296271 10.3390/vaccines10071124 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100010801 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100004587 35891288 2-s2.0-85137293155 https://api.elsevier.com/content/abstract/scopus_id/85137293155 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-112992RR-I00/ES/GENERACION DE VACUNAS UNIVERSALES DIVA FRENTE AL VIRUS DE LA LENGUA AZUL BASADAS EN VECTORES VIRALES MVA BICISTRONICOS Y ENSAYOS CELULARES PARA LA DETECCION RAPIDA DE NAB./ info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105308RB-I00/ES/NUEVOS ENFOQUES DE LA ENCAPSULACION DE PROTEINAS EN MICRO%2FNANOESFERAS BASADAS EN VIROPLASMAS PARA APLICACIONES INDUSTRIALES, TERAPEUTICAS E IMMUNOTERAPIA/ info:eu-repo/grantAgreement/Instituto de Salud Carlos III//COV20/00050 info:eu-repo/grantAgreement/ Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria//FPI-SGIT-2018) Vaccines Publisher's version https://doi.org/10.3390/vaccines10071124 Sí open Multidisciplinary Digital Publishing Institute

Nanoparticle- and Microparticle-Based Vaccines against Orbiviruses of Veterinary Importance

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