Reconciling West Nile virus with the autophagic pathway
West Nile virus (WNV) is a neurotropic mosquito-borne flavivirus responsible for recurrent outbreaks of meningitis and encephalitis. Several studies analyzing the interactions of this pathogen with the autophagic pathway have reported opposite results with evidence for and against the upregulation of autophagy in infected cells. In this regard, we have recently reported that minimal genetic changes (single amino acid substitutions) in nonstructural proteins of WNV can modify the ability of the virus to induce autophagic features such as LC3 modification and aggregation in infected cells. We think that these results could help explain some of the previously reported discrepancies. These findings could also aid in deciphering the interactions of this pathogen with the autophagic pathway at the molecular level aimed to develop feasible antiviral strategies to combat this pathogen, and other related flaviviruses. © 2015, Taylor & Francis Group, LLC.
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Format: | journal article biblioteca |
Language: | English |
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Taylor & Francis
2015
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Subjects: | Autophagy, Flavivirus, Infection, LC3, Mutants, Virus strain, West Nile virus (WNV), |
Online Access: | http://hdl.handle.net/20.500.12792/2670 http://hdl.handle.net/10261/294092 |
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dig-inia-es-10261-2940922023-02-20T10:35:11Z Reconciling West Nile virus with the autophagic pathway Martín-Acebes, M. A. Blázquez Martín, Ana Belén Saiz Calahorra, Juan Carlos Autophagy Flavivirus Infection LC3 Mutants Virus strain West Nile virus (WNV) West Nile virus (WNV) is a neurotropic mosquito-borne flavivirus responsible for recurrent outbreaks of meningitis and encephalitis. Several studies analyzing the interactions of this pathogen with the autophagic pathway have reported opposite results with evidence for and against the upregulation of autophagy in infected cells. In this regard, we have recently reported that minimal genetic changes (single amino acid substitutions) in nonstructural proteins of WNV can modify the ability of the virus to induce autophagic features such as LC3 modification and aggregation in infected cells. We think that these results could help explain some of the previously reported discrepancies. These findings could also aid in deciphering the interactions of this pathogen with the autophagic pathway at the molecular level aimed to develop feasible antiviral strategies to combat this pathogen, and other related flaviviruses. © 2015, Taylor & Francis Group, LLC. 2023-02-20T10:35:11Z 2023-02-20T10:35:11Z 2015 journal article Autophagy 11(5): 861-864 (2015) 1554-8627 http://hdl.handle.net/20.500.12792/2670 http://hdl.handle.net/10261/294092 10.1080/15548627.2015.1037062 1554-8635 en none Taylor & Francis |
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Autophagy Flavivirus Infection LC3 Mutants Virus strain West Nile virus (WNV) Autophagy Flavivirus Infection LC3 Mutants Virus strain West Nile virus (WNV) |
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Autophagy Flavivirus Infection LC3 Mutants Virus strain West Nile virus (WNV) Autophagy Flavivirus Infection LC3 Mutants Virus strain West Nile virus (WNV) Martín-Acebes, M. A. Blázquez Martín, Ana Belén Saiz Calahorra, Juan Carlos Reconciling West Nile virus with the autophagic pathway |
description |
West Nile virus (WNV) is a neurotropic mosquito-borne flavivirus responsible for recurrent outbreaks of meningitis and encephalitis. Several studies analyzing the interactions of this pathogen with the autophagic pathway have reported opposite results with evidence for and against the upregulation of autophagy in infected cells. In this regard, we have recently reported that minimal genetic changes (single amino acid substitutions) in nonstructural proteins of WNV can modify the ability of the virus to induce autophagic features such as LC3 modification and aggregation in infected cells. We think that these results could help explain some of the previously reported discrepancies. These findings could also aid in deciphering the interactions of this pathogen with the autophagic pathway at the molecular level aimed to develop feasible antiviral strategies to combat this pathogen, and other related flaviviruses. © 2015, Taylor & Francis Group, LLC. |
format |
journal article |
topic_facet |
Autophagy Flavivirus Infection LC3 Mutants Virus strain West Nile virus (WNV) |
author |
Martín-Acebes, M. A. Blázquez Martín, Ana Belén Saiz Calahorra, Juan Carlos |
author_facet |
Martín-Acebes, M. A. Blázquez Martín, Ana Belén Saiz Calahorra, Juan Carlos |
author_sort |
Martín-Acebes, M. A. |
title |
Reconciling West Nile virus with the autophagic pathway |
title_short |
Reconciling West Nile virus with the autophagic pathway |
title_full |
Reconciling West Nile virus with the autophagic pathway |
title_fullStr |
Reconciling West Nile virus with the autophagic pathway |
title_full_unstemmed |
Reconciling West Nile virus with the autophagic pathway |
title_sort |
reconciling west nile virus with the autophagic pathway |
publisher |
Taylor & Francis |
publishDate |
2015 |
url |
http://hdl.handle.net/20.500.12792/2670 http://hdl.handle.net/10261/294092 |
work_keys_str_mv |
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