The respiratory DC/macrophage network at steady-state and upon influenza infection in the swine biomedical model
Human and mouse respiratory tracts show anatomical and physiological differences, which will benefit from alternative experimental models for studying many respiratory diseases. Pig has been recognized as a valuable biomedical model, in particular for lung transplantation or pathologies such as cystic fibrosis and influenza infection. However, there is a lack of knowledge about the porcine respiratory immune system. Here we segregated and studied six populations of pig lung dendritic cells (DCs)/macrophages (Mθs) as follows conventional DCs (cDC) 1 and cDC2, inflammatory monocyte-derived DCs (moDCs), monocyte-derived Mθs, and interstitial and alveolar Mθs. The three DC subsets present migratory and naive T-cell stimulation capacities. As observed in human and mice, porcine cDC1 and cDC2 were able to induce T-helper (Th)1 and Th2 responses, respectively. Interestingly, porcine moDCs increased in the lung upon influenza infection, as observed in the mouse model. Pig cDC2 shared some characteristics observed in human but not in mice, such as the expression of FCϵRI and Langerin, and an intra-epithelial localization. This work, by unraveling the extended similarities of the porcine and human lung DC/Mθ networks, highlights the relevance of pig, both as an exploratory model of DC/Mθ functions and as a model for human inflammatory lung pathologies.
Main Authors: | , , , , , , , , , , , , , , |
---|---|
Format: | journal article biblioteca |
Language: | English |
Published: |
Springer Nature
2016
|
Online Access: | http://hdl.handle.net/20.500.12792/2576 http://hdl.handle.net/10261/293462 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
dig-inia-es-10261-293462 |
---|---|
record_format |
koha |
spelling |
dig-inia-es-10261-2934622023-02-20T10:28:46Z The respiratory DC/macrophage network at steady-state and upon influenza infection in the swine biomedical model Maisonnasse, P. Bouguyon, E. Piton, G. Ezquerra Martínez, Ángel Urien, C. Deloizy, C. Bourge, M. Leplat, J. J. Simon, G. Chevalier, C. Vincent-Naulleau, S. Crisci, E. Montoya, M. Schwartz-Cornil, I. Bertho, N. Human and mouse respiratory tracts show anatomical and physiological differences, which will benefit from alternative experimental models for studying many respiratory diseases. Pig has been recognized as a valuable biomedical model, in particular for lung transplantation or pathologies such as cystic fibrosis and influenza infection. However, there is a lack of knowledge about the porcine respiratory immune system. Here we segregated and studied six populations of pig lung dendritic cells (DCs)/macrophages (Mθs) as follows conventional DCs (cDC) 1 and cDC2, inflammatory monocyte-derived DCs (moDCs), monocyte-derived Mθs, and interstitial and alveolar Mθs. The three DC subsets present migratory and naive T-cell stimulation capacities. As observed in human and mice, porcine cDC1 and cDC2 were able to induce T-helper (Th)1 and Th2 responses, respectively. Interestingly, porcine moDCs increased in the lung upon influenza infection, as observed in the mouse model. Pig cDC2 shared some characteristics observed in human but not in mice, such as the expression of FCϵRI and Langerin, and an intra-epithelial localization. This work, by unraveling the extended similarities of the porcine and human lung DC/Mθ networks, highlights the relevance of pig, both as an exploratory model of DC/Mθ functions and as a model for human inflammatory lung pathologies. 2023-02-20T10:28:46Z 2023-02-20T10:28:46Z 2016 journal article Mucosal Immunology 9: 835-849 (2016) 1933-0219 http://hdl.handle.net/20.500.12792/2576 http://hdl.handle.net/10261/293462 10.1038/mi.2015.105 1935-3456 en none Springer Nature |
institution |
INIA ES |
collection |
DSpace |
country |
España |
countrycode |
ES |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-inia-es |
tag |
biblioteca |
region |
Europa del Sur |
libraryname |
Biblioteca del INIA España |
language |
English |
description |
Human and mouse respiratory tracts show anatomical and physiological differences, which will benefit from alternative experimental models for studying many respiratory diseases. Pig has been recognized as a valuable biomedical model, in particular for lung transplantation or pathologies such as cystic fibrosis and influenza infection. However, there is a lack of knowledge about the porcine respiratory immune system. Here we segregated and studied six populations of pig lung dendritic cells (DCs)/macrophages (Mθs) as follows conventional DCs (cDC) 1 and cDC2, inflammatory monocyte-derived DCs (moDCs), monocyte-derived Mθs, and interstitial and alveolar Mθs. The three DC subsets present migratory and naive T-cell stimulation capacities. As observed in human and mice, porcine cDC1 and cDC2 were able to induce T-helper (Th)1 and Th2 responses, respectively. Interestingly, porcine moDCs increased in the lung upon influenza infection, as observed in the mouse model. Pig cDC2 shared some characteristics observed in human but not in mice, such as the expression of FCϵRI and Langerin, and an intra-epithelial localization. This work, by unraveling the extended similarities of the porcine and human lung DC/Mθ networks, highlights the relevance of pig, both as an exploratory model of DC/Mθ functions and as a model for human inflammatory lung pathologies. |
format |
journal article |
author |
Maisonnasse, P. Bouguyon, E. Piton, G. Ezquerra Martínez, Ángel Urien, C. Deloizy, C. Bourge, M. Leplat, J. J. Simon, G. Chevalier, C. Vincent-Naulleau, S. Crisci, E. Montoya, M. Schwartz-Cornil, I. Bertho, N. |
spellingShingle |
Maisonnasse, P. Bouguyon, E. Piton, G. Ezquerra Martínez, Ángel Urien, C. Deloizy, C. Bourge, M. Leplat, J. J. Simon, G. Chevalier, C. Vincent-Naulleau, S. Crisci, E. Montoya, M. Schwartz-Cornil, I. Bertho, N. The respiratory DC/macrophage network at steady-state and upon influenza infection in the swine biomedical model |
author_facet |
Maisonnasse, P. Bouguyon, E. Piton, G. Ezquerra Martínez, Ángel Urien, C. Deloizy, C. Bourge, M. Leplat, J. J. Simon, G. Chevalier, C. Vincent-Naulleau, S. Crisci, E. Montoya, M. Schwartz-Cornil, I. Bertho, N. |
author_sort |
Maisonnasse, P. |
title |
The respiratory DC/macrophage network at steady-state and upon influenza infection in the swine biomedical model |
title_short |
The respiratory DC/macrophage network at steady-state and upon influenza infection in the swine biomedical model |
title_full |
The respiratory DC/macrophage network at steady-state and upon influenza infection in the swine biomedical model |
title_fullStr |
The respiratory DC/macrophage network at steady-state and upon influenza infection in the swine biomedical model |
title_full_unstemmed |
The respiratory DC/macrophage network at steady-state and upon influenza infection in the swine biomedical model |
title_sort |
respiratory dc/macrophage network at steady-state and upon influenza infection in the swine biomedical model |
publisher |
Springer Nature |
publishDate |
2016 |
url |
http://hdl.handle.net/20.500.12792/2576 http://hdl.handle.net/10261/293462 |
work_keys_str_mv |
AT maisonnassep therespiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT bouguyone therespiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT pitong therespiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT ezquerramartinezangel therespiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT urienc therespiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT deloizyc therespiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT bourgem therespiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT leplatjj therespiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT simong therespiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT chevalierc therespiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT vincentnaulleaus therespiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT criscie therespiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT montoyam therespiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT schwartzcornili therespiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT berthon therespiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT maisonnassep respiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT bouguyone respiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT pitong respiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT ezquerramartinezangel respiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT urienc respiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT deloizyc respiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT bourgem respiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT leplatjj respiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT simong respiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT chevalierc respiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT vincentnaulleaus respiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT criscie respiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT montoyam respiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT schwartzcornili respiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel AT berthon respiratorydcmacrophagenetworkatsteadystateanduponinfluenzainfectionintheswinebiomedicalmodel |
_version_ |
1767603479297130496 |