Chimpanzee adenovirus vaccine provides multispecies protection against Rift valley fever

Rift Valley Fever virus (RVFV) causes recurrent outbreaks of acute life-threatening human and livestock illness in Africa and the Arabian Peninsula. No licensed vaccines are currently available for humans and those widely used in livestock have major safety concerns. A One Health vaccine development approach, in which the same vaccine is co-developed for multiple susceptible species, is an attractive strategy for RVFV. Here, we utilized a replication-deficient chimpanzee adenovirus vaccine platform with an established human and livestock safety profile, ChAdOx1, to develop a vaccine for use against RVFV in both livestock and humans. We show that single-dose immunization with ChAdOx1-GnGc vaccine, encoding RVFV envelope glycoproteins, elicits high-titre RVFV-neutralizing antibody and provides solid protection against RVFV challenge in the most susceptible natural target species of the virus-sheep, goats and cattle. In addition we demonstrate induction of RVFV-neutralizing antibody by ChAdOx1-GnGc vaccination in dromedary camels, further illustrating the potency of replication-deficient chimpanzee adenovirus vaccine platforms. Thus, ChAdOx1-GnGc warrants evaluation in human clinical trials and could potentially address the unmet human and livestock vaccine needs.

Bibliographic Details

Main Authors:	Warimwe, G. M., Gesharisha, J., Carr, B. V., Otieno, S., Otingah, K., Wright, D., Charleston, B., Okoth, E., Lopez Gil, E, Ayman, E. B., Alharbi, N. K., Al-dubaib, M. A., Brun Torres, Alejandro, Gilbert, S. C., Nene, V., Hill, A. V. S., Lorenzo Alguacil, Gema
Format:	journal article biblioteca
Language:	English
Published:	Nature Research 2016
Online Access:	http://hdl.handle.net/20.500.12792/4761 http://hdl.handle.net/10261/293286
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